Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224996543> ?p ?o ?g. }
- W4224996543 abstract "Mycobacterium tuberculosis (Mtb) is the causative pathogen of tuberculosis (TB), which manipulates the host immunity to ensure survival and colonization in the host. Mtb possess a unique family of proteins, named PE_PGRS, associated with Mtb pathogenesis. Thus, elucidation of the functions of PE_PGRS proteins is necessary to understand TB pathogenesis. Here, we investigated the role of PE_PGRS38 binding to herpesvirus-associated ubiquitin-specific protease (HAUSP, USP7) in regulating the activity of various substrate proteins by modulating their state of ubiquitination. We constructed the recombinant PE_PGRS38 expressed in M. smegmatis (Ms_PE_PGRS38) to investigate the role of PE_PGRS38. We found that Ms_PE_PGRS38 regulated the cytokine levels in murine bone marrow-derived macrophages by inhibiting the deubiquitination of tumor necrosis factor receptor-associated factor (TRAF) 6 by HAUSP. Furthermore, the PE domain in PE_PGRS38 was identified as essential for mediating TRAF6 deubiquitination. Ms_PE_PGRS38 increased the intracellular burden of bacteria by manipulating cytokine levels in vitro and in vivo. Overall, we revealed that the interplay between HAUSP and PE_PGRS38 regulated the inflammatory response to increase the survival of mycobacteria." @default.
- W4224996543 created "2022-04-28" @default.
- W4224996543 creator A5003362173 @default.
- W4224996543 creator A5010785874 @default.
- W4224996543 creator A5016150343 @default.
- W4224996543 creator A5018449822 @default.
- W4224996543 creator A5021048660 @default.
- W4224996543 creator A5051050164 @default.
- W4224996543 creator A5088702133 @default.
- W4224996543 date "2022-04-28" @default.
- W4224996543 modified "2023-10-17" @default.
- W4224996543 title "PE_PGRS38 Interaction With HAUSP Downregulates Antimycobacterial Host Defense via TRAF6" @default.
- W4224996543 cites W1559176698 @default.
- W4224996543 cites W1766732272 @default.
- W4224996543 cites W1906780201 @default.
- W4224996543 cites W1915965704 @default.
- W4224996543 cites W1961110915 @default.
- W4224996543 cites W1969555953 @default.
- W4224996543 cites W1972851920 @default.
- W4224996543 cites W1983128127 @default.
- W4224996543 cites W1993436422 @default.
- W4224996543 cites W1995682111 @default.
- W4224996543 cites W2000724093 @default.
- W4224996543 cites W2011089730 @default.
- W4224996543 cites W2021936643 @default.
- W4224996543 cites W2025802982 @default.
- W4224996543 cites W2027399746 @default.
- W4224996543 cites W2032741035 @default.
- W4224996543 cites W2050475053 @default.
- W4224996543 cites W2065886319 @default.
- W4224996543 cites W2072602445 @default.
- W4224996543 cites W2075493224 @default.
- W4224996543 cites W2081773790 @default.
- W4224996543 cites W2084003414 @default.
- W4224996543 cites W2086796237 @default.
- W4224996543 cites W2095424116 @default.
- W4224996543 cites W2111062185 @default.
- W4224996543 cites W2120387439 @default.
- W4224996543 cites W2122947253 @default.
- W4224996543 cites W2126282766 @default.
- W4224996543 cites W2127217324 @default.
- W4224996543 cites W2143228770 @default.
- W4224996543 cites W2149489418 @default.
- W4224996543 cites W2155027778 @default.
- W4224996543 cites W2155090438 @default.
- W4224996543 cites W2329841178 @default.
- W4224996543 cites W2509271126 @default.
- W4224996543 cites W2564968569 @default.
- W4224996543 cites W2581579460 @default.
- W4224996543 cites W2609244548 @default.
- W4224996543 cites W2752890220 @default.
- W4224996543 cites W2766320058 @default.
- W4224996543 cites W2808915963 @default.
- W4224996543 cites W2809511392 @default.
- W4224996543 cites W2925450942 @default.
- W4224996543 cites W2973163858 @default.
- W4224996543 cites W2984115711 @default.
- W4224996543 cites W2999189538 @default.
- W4224996543 cites W3033253541 @default.
- W4224996543 cites W3045037206 @default.
- W4224996543 cites W3082696647 @default.
- W4224996543 cites W3106935673 @default.
- W4224996543 cites W3156937120 @default.
- W4224996543 doi "https://doi.org/10.3389/fimmu.2022.862628" @default.
- W4224996543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35572598" @default.
- W4224996543 hasPublicationYear "2022" @default.
- W4224996543 type Work @default.
- W4224996543 citedByCount "3" @default.
- W4224996543 countsByYear W42249965432023 @default.
- W4224996543 crossrefType "journal-article" @default.
- W4224996543 hasAuthorship W4224996543A5003362173 @default.
- W4224996543 hasAuthorship W4224996543A5010785874 @default.
- W4224996543 hasAuthorship W4224996543A5016150343 @default.
- W4224996543 hasAuthorship W4224996543A5018449822 @default.
- W4224996543 hasAuthorship W4224996543A5021048660 @default.
- W4224996543 hasAuthorship W4224996543A5051050164 @default.
- W4224996543 hasAuthorship W4224996543A5088702133 @default.
- W4224996543 hasBestOaLocation W42249965431 @default.
- W4224996543 hasConcept C142724271 @default.
- W4224996543 hasConcept C17991360 @default.
- W4224996543 hasConcept C203014093 @default.
- W4224996543 hasConcept C2777204207 @default.
- W4224996543 hasConcept C2777975735 @default.
- W4224996543 hasConcept C2778690821 @default.
- W4224996543 hasConcept C2780374374 @default.
- W4224996543 hasConcept C2780942790 @default.
- W4224996543 hasConcept C2781069245 @default.
- W4224996543 hasConcept C523546767 @default.
- W4224996543 hasConcept C54355233 @default.
- W4224996543 hasConcept C71924100 @default.
- W4224996543 hasConcept C86803240 @default.
- W4224996543 hasConcept C89423630 @default.
- W4224996543 hasConceptScore W4224996543C142724271 @default.
- W4224996543 hasConceptScore W4224996543C17991360 @default.
- W4224996543 hasConceptScore W4224996543C203014093 @default.
- W4224996543 hasConceptScore W4224996543C2777204207 @default.
- W4224996543 hasConceptScore W4224996543C2777975735 @default.
- W4224996543 hasConceptScore W4224996543C2778690821 @default.
- W4224996543 hasConceptScore W4224996543C2780374374 @default.
- W4224996543 hasConceptScore W4224996543C2780942790 @default.