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- W4225006102 abstract "Abstract Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states. Persistent neuroinflammation is considered a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson's disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS) and primary progressive multiple sclerosis (MS). Colony stimulating factor 1-receptor (CSF-1R) is predominantly expressed on microglia and its expression is significantly increased in neurodegenerative diseases. Cumulative findings have indicated that CSF-1R inhibitors can have beneficial effects in preclinical neurodegenerative disease models. Research using CSF-1R inhibitors has now been extended into non-human primates and humans. This review article summarizes the most recent advances using CSF-1R inhibitors in different neurodegenerative conditions including AD, PD, HD, ALS and MS. Potential challenges for translating these findings into clinical practice are presented." @default.
- W4225006102 created "2022-04-29" @default.
- W4225006102 creator A5001561478 @default.
- W4225006102 creator A5022481370 @default.
- W4225006102 creator A5060336953 @default.
- W4225006102 creator A5070191665 @default.
- W4225006102 creator A5079662311 @default.
- W4225006102 creator A5082228294 @default.
- W4225006102 date "2022-04-01" @default.
- W4225006102 modified "2023-10-18" @default.
- W4225006102 title "Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges" @default.
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