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• W4225006721 endingPage "4759" @default.
• W4225006721 startingPage "4759" @default.
• W4225006721 abstract "The discovery of functional brown adipose tissue (BAT) in adult humans and the possibility to recruit beige cells with high thermogenic potential within white adipose tissue (WAT) depots opened the field for new strategies to combat obesity and its associated comorbidities. Exercise training as well as cold exposure and dietary components are associated with the enhanced accumulation of metabolically-active beige adipocytes and BAT activation. Both activated beige and brown adipocytes increase their metabolic rate by utilizing lipids to generate heat via non-shivering thermogenesis, which is dependent on uncoupling protein 1 (UCP1) in the inner mitochondrial membrane. Non-shivering thermogenesis elevates energy expenditure and promotes a negative energy balance, which may ameliorate metabolic complications of obesity and Type 2 Diabetes Mellitus (T2DM) such as insulin resistance (IR) in skeletal muscle and adipose tissue. Despite the recent advances in pharmacological approaches to reduce obesity and IR by inducing non-shivering thermogenesis in BAT and WAT, the administered pharmacological compounds are often associated with unwanted side effects. Therefore, lifestyle interventions such as exercise, cold exposure, and/or specified dietary regimens present promising anchor points for future disease prevention and treatment of obesity and T2DM. The exact mechanisms where exercise, cold exposure, dietary interventions, and pharmacological treatments converge or rather diverge in their specific impact on BAT activation or WAT browning are difficult to determine. In the past, many reviews have demonstrated the mechanistic principles of exercise- and/or cold-induced BAT activation and WAT browning. In this review, we aim to summarize not only the current state of knowledge on the various mechanistic principles of diverse external stimuli on BAT activation and WAT browning, but also present their translational potential in future clinical applications." @default.
• W4225006721 created "2022-04-29" @default.
• W4225006721 creator A5043699942 @default.
• W4225006721 creator A5044497597 @default.
• W4225006721 creator A5049613897 @default.
• W4225006721 date "2022-04-26" @default.
• W4225006721 modified "2023-10-14" @default.
• W4225006721 title "Many Ways to Rome: Exercise, Cold Exposure and Diet—Do They All Affect BAT Activation and WAT Browning in the Same Manner?" @default.
• W4225006721 cites W1127264686 @default.
• W4225006721 cites W1200115021 @default.
• W4225006721 cites W1501655398 @default.
• W4225006721 cites W1634292063 @default.
• W4225006721 cites W1773423156 @default.
• W4225006721 cites W1829445008 @default.
• W4225006721 cites W1835812283 @default.
• W4225006721 cites W1877854265 @default.
• W4225006721 cites W1901236233 @default.
• W4225006721 cites W1908141864 @default.
• W4225006721 cites W1924912806 @default.
• W4225006721 cites W1947875006 @default.
• W4225006721 cites W1965079305 @default.
• W4225006721 cites W1965478486 @default.
• W4225006721 cites W1970434966 @default.
• W4225006721 cites W1970930429 @default.
• W4225006721 cites W1972090599 @default.
• W4225006721 cites W1974559463 @default.
• W4225006721 cites W1974792437 @default.
• W4225006721 cites W1976676611 @default.
• W4225006721 cites W1979393880 @default.
• W4225006721 cites W1980335514 @default.
• W4225006721 cites W1981281539 @default.
• W4225006721 cites W1984956709 @default.
• W4225006721 cites W1985594200 @default.
• W4225006721 cites W1986349550 @default.
• W4225006721 cites W1986602268 @default.
• W4225006721 cites W1988372369 @default.
• W4225006721 cites W1988869711 @default.
• W4225006721 cites W1989643083 @default.
• W4225006721 cites W1991845771 @default.
• W4225006721 cites W1992547263 @default.
• W4225006721 cites W1992771950 @default.
• W4225006721 cites W1995081715 @default.
• W4225006721 cites W1997704546 @default.
• W4225006721 cites W1997980715 @default.
• W4225006721 cites W1998200002 @default.
• W4225006721 cites W1999986580 @default.
• W4225006721 cites W2001138121 @default.
• W4225006721 cites W2001657480 @default.
• W4225006721 cites W2002127124 @default.
• W4225006721 cites W2002745120 @default.
• W4225006721 cites W2004889053 @default.
• W4225006721 cites W2006361510 @default.
• W4225006721 cites W2006830741 @default.
• W4225006721 cites W2007715079 @default.
• W4225006721 cites W2009181620 @default.
• W4225006721 cites W2013501507 @default.
• W4225006721 cites W2013900763 @default.
• W4225006721 cites W2018068211 @default.
• W4225006721 cites W2018863236 @default.
• W4225006721 cites W2022349101 @default.
• W4225006721 cites W2022737924 @default.
• W4225006721 cites W2027753197 @default.
• W4225006721 cites W2029201376 @default.
• W4225006721 cites W2032689723 @default.
• W4225006721 cites W2035963507 @default.
• W4225006721 cites W2038961236 @default.
• W4225006721 cites W2040190888 @default.
• W4225006721 cites W2044359703 @default.
• W4225006721 cites W2044843840 @default.
• W4225006721 cites W2045656711 @default.
• W4225006721 cites W2047306805 @default.
• W4225006721 cites W2048771411 @default.
• W4225006721 cites W2050081916 @default.
• W4225006721 cites W2051993213 @default.
• W4225006721 cites W2053614711 @default.
• W4225006721 cites W2055608265 @default.
• W4225006721 cites W2060449981 @default.
• W4225006721 cites W2061382815 @default.
• W4225006721 cites W2062244719 @default.
• W4225006721 cites W2062650033 @default.
• W4225006721 cites W2067096633 @default.
• W4225006721 cites W2067257932 @default.
• W4225006721 cites W2071831587 @default.
• W4225006721 cites W2073755736 @default.
• W4225006721 cites W2076503188 @default.
• W4225006721 cites W2076975132 @default.
• W4225006721 cites W2078325369 @default.
• W4225006721 cites W2079200391 @default.
• W4225006721 cites W2083602312 @default.
• W4225006721 cites W2083855314 @default.
• W4225006721 cites W2084692792 @default.
• W4225006721 cites W2085397620 @default.
• W4225006721 cites W2086562954 @default.
• W4225006721 cites W2090676154 @default.
• W4225006721 cites W2092320751 @default.
• W4225006721 cites W2096698919 @default.
• W4225006721 cites W2097615700 @default.
• W4225006721 cites W2099505534 @default.

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