Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225009719> ?p ?o ?g. }
- W4225009719 endingPage "100875" @default.
- W4225009719 startingPage "100875" @default.
- W4225009719 abstract "Diabetes mellitus is one of the most chronic metabolic diseases. Since past few years, our research group had synthesized and evaluated libraries of heterocyclic analogues against α-amylase enzyme and found encouraging results. The current study comprises of evaluation of triazinoindole bearing sulfonamide as antidiabetic agents. A library of twenty three analogues (1–23) were synthesized, characterized through 1HNMR, 13C NMR and HREI-MS and evaluated for α-amylase inhibitory potential. Off twenty three, nine analogues 1, 2, 3, 6, 7, 8, 12, 13 and 14 displayed excellent inhibitory potential against α-amylase enzyme with IC50 values 0.60 ± 0.05, 1.10 ± 0.05, 1.20 ± 0.05, 1.60 ± 0.10, 1.40 ± 0.10, 1.40 ± 0.10, 0.80 ± 0.05, 0.30 ± 0.05 and 1.50 ± 0.10 µM, respectively. These analogues may potentially serve as lead for the development of new therapeutic representatives. Moreover, in silico docking study were carried out to investigate active binding mode of selected analogues with the target enzyme." @default.
- W4225009719 created "2022-04-29" @default.
- W4225009719 creator A5039833072 @default.
- W4225009719 creator A5047089632 @default.
- W4225009719 creator A5052090673 @default.
- W4225009719 creator A5052148205 @default.
- W4225009719 creator A5073202152 @default.
- W4225009719 creator A5086422606 @default.
- W4225009719 date "2022-06-01" @default.
- W4225009719 modified "2023-10-16" @default.
- W4225009719 title "Synthesis of triazinoindole bearing sulfonamide derivatives, in vitro α-amylase activity and their molecular docking study" @default.
- W4225009719 cites W1174807774 @default.
- W4225009719 cites W1786884398 @default.
- W4225009719 cites W1967263511 @default.
- W4225009719 cites W1991562979 @default.
- W4225009719 cites W2006522535 @default.
- W4225009719 cites W2027283662 @default.
- W4225009719 cites W2048498907 @default.
- W4225009719 cites W2058048022 @default.
- W4225009719 cites W2059067578 @default.
- W4225009719 cites W2065011801 @default.
- W4225009719 cites W2092866901 @default.
- W4225009719 cites W2096661451 @default.
- W4225009719 cites W2105211035 @default.
- W4225009719 cites W2123334414 @default.
- W4225009719 cites W2128788119 @default.
- W4225009719 cites W2152542478 @default.
- W4225009719 cites W2281312545 @default.
- W4225009719 cites W2460062919 @default.
- W4225009719 cites W2505843028 @default.
- W4225009719 cites W2561117424 @default.
- W4225009719 cites W2606178383 @default.
- W4225009719 cites W2610747357 @default.
- W4225009719 cites W2734937587 @default.
- W4225009719 cites W2737953027 @default.
- W4225009719 cites W2742338598 @default.
- W4225009719 cites W2765227482 @default.
- W4225009719 cites W2879063409 @default.
- W4225009719 cites W3025112645 @default.
- W4225009719 cites W3039476755 @default.
- W4225009719 cites W3177448875 @default.
- W4225009719 cites W3184457238 @default.
- W4225009719 cites W3214748600 @default.
- W4225009719 doi "https://doi.org/10.1016/j.cdc.2022.100875" @default.
- W4225009719 hasPublicationYear "2022" @default.
- W4225009719 type Work @default.
- W4225009719 citedByCount "9" @default.
- W4225009719 countsByYear W42250097192022 @default.
- W4225009719 countsByYear W42250097192023 @default.
- W4225009719 crossrefType "journal-article" @default.
- W4225009719 hasAuthorship W4225009719A5039833072 @default.
- W4225009719 hasAuthorship W4225009719A5047089632 @default.
- W4225009719 hasAuthorship W4225009719A5052090673 @default.
- W4225009719 hasAuthorship W4225009719A5052148205 @default.
- W4225009719 hasAuthorship W4225009719A5073202152 @default.
- W4225009719 hasAuthorship W4225009719A5086422606 @default.
- W4225009719 hasConcept C104317684 @default.
- W4225009719 hasConcept C159110408 @default.
- W4225009719 hasConcept C170835558 @default.
- W4225009719 hasConcept C181199279 @default.
- W4225009719 hasConcept C185592680 @default.
- W4225009719 hasConcept C202751555 @default.
- W4225009719 hasConcept C21951064 @default.
- W4225009719 hasConcept C2775905019 @default.
- W4225009719 hasConcept C2777752497 @default.
- W4225009719 hasConcept C2781039511 @default.
- W4225009719 hasConcept C41183919 @default.
- W4225009719 hasConcept C41685203 @default.
- W4225009719 hasConcept C55493867 @default.
- W4225009719 hasConcept C71240020 @default.
- W4225009719 hasConcept C71924100 @default.
- W4225009719 hasConcept C98274493 @default.
- W4225009719 hasConceptScore W4225009719C104317684 @default.
- W4225009719 hasConceptScore W4225009719C159110408 @default.
- W4225009719 hasConceptScore W4225009719C170835558 @default.
- W4225009719 hasConceptScore W4225009719C181199279 @default.
- W4225009719 hasConceptScore W4225009719C185592680 @default.
- W4225009719 hasConceptScore W4225009719C202751555 @default.
- W4225009719 hasConceptScore W4225009719C21951064 @default.
- W4225009719 hasConceptScore W4225009719C2775905019 @default.
- W4225009719 hasConceptScore W4225009719C2777752497 @default.
- W4225009719 hasConceptScore W4225009719C2781039511 @default.
- W4225009719 hasConceptScore W4225009719C41183919 @default.
- W4225009719 hasConceptScore W4225009719C41685203 @default.
- W4225009719 hasConceptScore W4225009719C55493867 @default.
- W4225009719 hasConceptScore W4225009719C71240020 @default.
- W4225009719 hasConceptScore W4225009719C71924100 @default.
- W4225009719 hasConceptScore W4225009719C98274493 @default.
- W4225009719 hasLocation W42250097191 @default.
- W4225009719 hasOpenAccess W4225009719 @default.
- W4225009719 hasPrimaryLocation W42250097191 @default.
- W4225009719 hasRelatedWork W1987588929 @default.
- W4225009719 hasRelatedWork W2004834660 @default.
- W4225009719 hasRelatedWork W2060843983 @default.
- W4225009719 hasRelatedWork W2073906535 @default.
- W4225009719 hasRelatedWork W2356858045 @default.
- W4225009719 hasRelatedWork W2416763146 @default.
- W4225009719 hasRelatedWork W3008566398 @default.