FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225014366> ?p ?o ?g. }

• W4225014366 endingPage "402" @default.
• W4225014366 startingPage "393" @default.
• W4225014366 abstract "The hypothalamus is a central regulator of body weight and energy homeostasis. There is increasing evidence that innate immune activation in the mediobasal hypothalamus (MBH) is a key element in the pathogenesis of diet-induced obesity. Microglia, the resident immune cells in the brain parenchyma, have been shown to play roles in diverse aspects of brain function, including circuit refinement and synaptic pruning. As such, microglia have also been implicated in the development and progression of neurological diseases. Microglia express receptors for and are responsive to a wide variety of nutritional, hormonal, and immunological signals that modulate their distinct functions across different brain regions. We showed that microglia within the MBH sense and respond to a high-fat diet and regulate the function of hypothalamic neurons to promote food intake and obesity. Neurons, glia, and immune cells within the MBH are positioned to sense and respond to circulating signals that regulate their capacity to coordinate aspects of systemic energy metabolism. Here, we review the current knowledge of how these peripheral signals modulate the innate immune response in the MBH and enable microglia to regulate metabolic control." @default.
• W4225014366 created "2022-04-29" @default.
• W4225014366 creator A5010475028 @default.
• W4225014366 creator A5018863144 @default.
• W4225014366 creator A5073179411 @default.
• W4225014366 creator A5090500596 @default.
• W4225014366 date "2022-04-26" @default.
• W4225014366 modified "2023-10-15" @default.
• W4225014366 title "Metabolic factors in the regulation of hypothalamic innate immune responses in obesity" @default.
• W4225014366 cites W1511961767 @default.
• W4225014366 cites W1515023627 @default.
• W4225014366 cites W1537277145 @default.
• W4225014366 cites W1558985734 @default.
• W4225014366 cites W1800539910 @default.
• W4225014366 cites W1948478725 @default.
• W4225014366 cites W1964562779 @default.
• W4225014366 cites W1965072462 @default.
• W4225014366 cites W1971415551 @default.
• W4225014366 cites W1971604081 @default.
• W4225014366 cites W1972534236 @default.
• W4225014366 cites W1974559463 @default.
• W4225014366 cites W1979509360 @default.
• W4225014366 cites W1980789245 @default.
• W4225014366 cites W1986142882 @default.
• W4225014366 cites W1992304191 @default.
• W4225014366 cites W1997672049 @default.
• W4225014366 cites W2010911569 @default.
• W4225014366 cites W2013776157 @default.
• W4225014366 cites W2014156217 @default.
• W4225014366 cites W2017712441 @default.
• W4225014366 cites W2018927139 @default.
• W4225014366 cites W2025131475 @default.
• W4225014366 cites W2025772141 @default.
• W4225014366 cites W2030818171 @default.
• W4225014366 cites W2032322539 @default.
• W4225014366 cites W2033617297 @default.
• W4225014366 cites W2038970961 @default.
• W4225014366 cites W2040901874 @default.
• W4225014366 cites W2044546427 @default.
• W4225014366 cites W2053569048 @default.
• W4225014366 cites W2054275187 @default.
• W4225014366 cites W2064431660 @default.
• W4225014366 cites W2065678433 @default.
• W4225014366 cites W2065697164 @default.
• W4225014366 cites W2067875627 @default.
• W4225014366 cites W2068234766 @default.
• W4225014366 cites W2070139936 @default.
• W4225014366 cites W2071753918 @default.
• W4225014366 cites W2073528314 @default.
• W4225014366 cites W2074625678 @default.
• W4225014366 cites W2076140273 @default.
• W4225014366 cites W2085158900 @default.
• W4225014366 cites W2088207247 @default.
• W4225014366 cites W2097447032 @default.
• W4225014366 cites W2100011299 @default.
• W4225014366 cites W2100386453 @default.
• W4225014366 cites W2104890139 @default.
• W4225014366 cites W2106348916 @default.
• W4225014366 cites W2115510547 @default.
• W4225014366 cites W2120559894 @default.
• W4225014366 cites W2124244382 @default.
• W4225014366 cites W2125296039 @default.
• W4225014366 cites W2127242333 @default.
• W4225014366 cites W2128395587 @default.
• W4225014366 cites W2128485668 @default.
• W4225014366 cites W2128994172 @default.
• W4225014366 cites W2130495917 @default.
• W4225014366 cites W2131536322 @default.
• W4225014366 cites W2131686384 @default.
• W4225014366 cites W2132681327 @default.
• W4225014366 cites W2135642402 @default.
• W4225014366 cites W2140233939 @default.
• W4225014366 cites W2143809126 @default.
• W4225014366 cites W2143903606 @default.
• W4225014366 cites W2148366635 @default.
• W4225014366 cites W2148898943 @default.
• W4225014366 cites W2152003280 @default.
• W4225014366 cites W2154696002 @default.
• W4225014366 cites W2162668563 @default.
• W4225014366 cites W2163865122 @default.
• W4225014366 cites W2165733524 @default.
• W4225014366 cites W2280077905 @default.
• W4225014366 cites W2286593787 @default.
• W4225014366 cites W2345745180 @default.
• W4225014366 cites W2465638754 @default.
• W4225014366 cites W2519262962 @default.
• W4225014366 cites W2537351581 @default.
• W4225014366 cites W2557682509 @default.
• W4225014366 cites W2558045643 @default.
• W4225014366 cites W2561923085 @default.
• W4225014366 cites W2590423176 @default.
• W4225014366 cites W2591971201 @default.
• W4225014366 cites W2602024874 @default.
• W4225014366 cites W2602366195 @default.
• W4225014366 cites W2606480102 @default.
• W4225014366 cites W2612276668 @default.
• W4225014366 cites W2612632190 @default.
• W4225014366 cites W2617648952 @default.

• next