Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225097002> ?p ?o ?g. }
- W4225097002 endingPage "1221" @default.
- W4225097002 startingPage "1203" @default.
- W4225097002 abstract "Melatonin (N-acetyl-5-methoxytryptamine), a chief secretory molecule of the pineal gland, has multiple properties, and numerous clinical investigations regarding its actions are in progress. This study investigated the radiomitigative role of melatonin in C57BL/6 mice.Melatonin (100 mg/kg) was orally administered once daily starting at 1 h on day 1 and subsequently every 24 h until day 7 after whole-body irradiation (WBI) and survival was monitored for 30 days. The bone marrow, spleen, and intestine were studied to evaluate the mitigative potential of melatonin after radiation-induced damage.Melatonin significantly improved the survival upto 60% and 90% after 9 Gy (lethal) and 7.5 Gy (sub-lethal) WBI, respectively. Melatonin alleviated WBI-induced myelosuppression and pancytopenia, and increased white blood cell, red blood cell, platelet, and lymphocyte (CD4+ and CD8+) counts in peripheral blood. Bone marrow and spleen cellularity were restored through enhanced haematopoiesis. Melatonin ameliorated the damage in the small intestine, and promoted recovery of villi length, crypts number, and goblet cell count.Melatonin mitigates the radiation-induced injury in the gastrointestinal and haematopoietic systems. The observed radiomitigative properties of melatonin can also be useful in the context of adjuvant therapy for cancer and radiotherapy." @default.
- W4225097002 created "2022-04-30" @default.
- W4225097002 creator A5012716772 @default.
- W4225097002 creator A5021398424 @default.
- W4225097002 creator A5043737767 @default.
- W4225097002 date "2022-01-01" @default.
- W4225097002 modified "2023-10-09" @default.
- W4225097002 title "Radiomitigation by Melatonin in C57BL/6 Mice: Possible Implications as Adjuvant in Radiotherapy and Chemotherapy" @default.
- W4225097002 cites W1480722843 @default.
- W4225097002 cites W1485425314 @default.
- W4225097002 cites W1528384739 @default.
- W4225097002 cites W1584483067 @default.
- W4225097002 cites W1714103394 @default.
- W4225097002 cites W1912124796 @default.
- W4225097002 cites W1919390294 @default.
- W4225097002 cites W1943914497 @default.
- W4225097002 cites W1964187078 @default.
- W4225097002 cites W1975967573 @default.
- W4225097002 cites W1978240169 @default.
- W4225097002 cites W1982945924 @default.
- W4225097002 cites W1985718591 @default.
- W4225097002 cites W1987633541 @default.
- W4225097002 cites W1989133022 @default.
- W4225097002 cites W1992830797 @default.
- W4225097002 cites W2005870177 @default.
- W4225097002 cites W2005971420 @default.
- W4225097002 cites W2010666233 @default.
- W4225097002 cites W2013208041 @default.
- W4225097002 cites W2019923469 @default.
- W4225097002 cites W2031588447 @default.
- W4225097002 cites W2031602421 @default.
- W4225097002 cites W2033575211 @default.
- W4225097002 cites W2033961046 @default.
- W4225097002 cites W2034348289 @default.
- W4225097002 cites W2038646308 @default.
- W4225097002 cites W2040891632 @default.
- W4225097002 cites W2042307924 @default.
- W4225097002 cites W2043774516 @default.
- W4225097002 cites W2048761824 @default.
- W4225097002 cites W2053474729 @default.
- W4225097002 cites W2057485681 @default.
- W4225097002 cites W2060132953 @default.
- W4225097002 cites W2062393079 @default.
- W4225097002 cites W2068157660 @default.
- W4225097002 cites W2069557953 @default.
- W4225097002 cites W2070055629 @default.
- W4225097002 cites W2071247163 @default.
- W4225097002 cites W2073925044 @default.
- W4225097002 cites W2081221446 @default.
- W4225097002 cites W2085332079 @default.
- W4225097002 cites W2089066699 @default.
- W4225097002 cites W2090218347 @default.
- W4225097002 cites W2096484869 @default.
- W4225097002 cites W2098777338 @default.
- W4225097002 cites W2100140007 @default.
- W4225097002 cites W2103486381 @default.
- W4225097002 cites W2105714694 @default.
- W4225097002 cites W2107489644 @default.
- W4225097002 cites W2107830839 @default.
- W4225097002 cites W2114964734 @default.
- W4225097002 cites W2120382735 @default.
- W4225097002 cites W2122498073 @default.
- W4225097002 cites W2131724495 @default.
- W4225097002 cites W2146953595 @default.
- W4225097002 cites W2147148460 @default.
- W4225097002 cites W2149548670 @default.
- W4225097002 cites W2151576881 @default.
- W4225097002 cites W2159093995 @default.
- W4225097002 cites W2168951031 @default.
- W4225097002 cites W2169633913 @default.
- W4225097002 cites W2170448720 @default.
- W4225097002 cites W2228599390 @default.
- W4225097002 cites W2257942969 @default.
- W4225097002 cites W2274769344 @default.
- W4225097002 cites W2293067593 @default.
- W4225097002 cites W2318107101 @default.
- W4225097002 cites W2341557816 @default.
- W4225097002 cites W2402351661 @default.
- W4225097002 cites W2600664027 @default.
- W4225097002 cites W2606321562 @default.
- W4225097002 cites W2606778500 @default.
- W4225097002 cites W2609808352 @default.
- W4225097002 cites W2746026190 @default.
- W4225097002 cites W2759457207 @default.
- W4225097002 cites W2759497087 @default.
- W4225097002 cites W2772953568 @default.
- W4225097002 cites W2791279069 @default.
- W4225097002 cites W2895817675 @default.
- W4225097002 cites W2939616315 @default.
- W4225097002 cites W2941607887 @default.
- W4225097002 cites W2965676550 @default.
- W4225097002 cites W2966483284 @default.
- W4225097002 cites W2971180845 @default.
- W4225097002 cites W2985209925 @default.
- W4225097002 cites W2992503005 @default.
- W4225097002 cites W3028021130 @default.
- W4225097002 cites W3083502557 @default.
- W4225097002 cites W3128722297 @default.