Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225101407> ?p ?o ?g. }
- W4225101407 endingPage "465" @default.
- W4225101407 startingPage "449" @default.
- W4225101407 abstract "Abstract Patterned stimulation of the locus coeruleus (LC, 100 Hz), in conjunction with test‐pulse stimulation of hippocampal afferents, results in input‐specific long‐term depression (LTD) of synaptic plasticity in the hippocampus. Effects are long‐lasting and have been described in Schaffer‐collateral–CA1 and perforant path‐dentate gyrus synapses in behaving rats. To what extent LC‐mediated hippocampal LTD (LC‐LTD) is frequency‐dependent is unclear. Here, we report that LC‐LTD can be triggered by LC stimulation with 2 and 5 Hz akin to tonic activity, 10 Hz equivalent to phasic activity, and 100 Hz akin to high‐phasic activity in the dentate gyrus (DG) of freely behaving rats. LC‐LTD at both 2 and 100 Hz can be significantly prevented by an NMDA receptor antagonist. The LC releases both noradrenaline (NA) and dopamine (DA) from its hippocampal terminals and may also trigger hippocampal DA release by activating the ventral tegmental area (VTA). Unclear is whether both neurotransmitters contribute equally to hippocampal LTD triggered by LC stimulation (LC‐LTD). Both DA D1/D5 receptors (D1/D5R) and beta‐adrenergic receptors (β‐AR) are critically required for hippocampal LTD that is induced by patterned stimulation of hippocampal afferents, or is facilitated by spatial learning. We, therefore, explored to what extent these receptor subtypes mediate frequency‐dependent hippocampal LC‐LTD. LC‐LTD elicited by 2, 5, and 10 Hz stimulation was unaffected by antagonism of β‐AR with propranolol, whereas LC‐LTD induced by these frequencies was prevented by D1/D5R‐antagonism using SCH23390. By contrast, LC‐LTD evoked at 100 Hz was prevented by β‐AR‐antagonism and only mildly affected by D1/D5R‐antagonism. Taken together, these findings support that LC‐LTD can be triggered by LC activity at a wide range of frequencies. Furthermore, the contribution of D1/D5R and β‐AR to hippocampal LTD that is triggered by LC activity is frequency‐dependent and suggests that D1/D5R may be involved in LC‐mediated hippocampal tonus." @default.
- W4225101407 created "2022-04-30" @default.
- W4225101407 creator A5024176519 @default.
- W4225101407 creator A5088479437 @default.
- W4225101407 date "2022-04-28" @default.
- W4225101407 modified "2023-10-18" @default.
- W4225101407 title "Frequency–dependency of the involvement of dopamine <scp>D1</scp>/<scp>D5</scp> and beta‐adrenergic receptors in hippocampal <scp>LTD</scp> triggered by locus coeruleus stimulation" @default.
- W4225101407 cites W1487826806 @default.
- W4225101407 cites W1579201202 @default.
- W4225101407 cites W1606808023 @default.
- W4225101407 cites W1612007229 @default.
- W4225101407 cites W1634005937 @default.
- W4225101407 cites W1652457627 @default.
- W4225101407 cites W1745700293 @default.
- W4225101407 cites W1810663112 @default.
- W4225101407 cites W1849626795 @default.
- W4225101407 cites W1943789780 @default.
- W4225101407 cites W1969550982 @default.
- W4225101407 cites W1969781703 @default.
- W4225101407 cites W1970607961 @default.
- W4225101407 cites W1974311568 @default.
- W4225101407 cites W1974600573 @default.
- W4225101407 cites W1975477712 @default.
- W4225101407 cites W1976717011 @default.
- W4225101407 cites W1977542480 @default.
- W4225101407 cites W1977815909 @default.
- W4225101407 cites W1983985508 @default.
- W4225101407 cites W1988152811 @default.
- W4225101407 cites W1988645512 @default.
- W4225101407 cites W1991216772 @default.
- W4225101407 cites W1995176921 @default.
- W4225101407 cites W1998173762 @default.
- W4225101407 cites W1999464270 @default.
- W4225101407 cites W2007250963 @default.
- W4225101407 cites W2009445378 @default.
- W4225101407 cites W2010384191 @default.
- W4225101407 cites W2012753124 @default.
- W4225101407 cites W2014459859 @default.
- W4225101407 cites W2016014417 @default.
- W4225101407 cites W2018784755 @default.
- W4225101407 cites W2020957587 @default.
- W4225101407 cites W2022333446 @default.
- W4225101407 cites W2024240145 @default.
- W4225101407 cites W2027882681 @default.
- W4225101407 cites W2028466783 @default.
- W4225101407 cites W2028487839 @default.
- W4225101407 cites W2028606712 @default.
- W4225101407 cites W2032480220 @default.
- W4225101407 cites W2039016127 @default.
- W4225101407 cites W2039645654 @default.
- W4225101407 cites W2043615144 @default.
- W4225101407 cites W2045522459 @default.
- W4225101407 cites W2049735948 @default.
- W4225101407 cites W2052445918 @default.
- W4225101407 cites W2052908314 @default.
- W4225101407 cites W2054155432 @default.
- W4225101407 cites W2054280306 @default.
- W4225101407 cites W2055049966 @default.
- W4225101407 cites W2056156210 @default.
- W4225101407 cites W2062815868 @default.
- W4225101407 cites W2062824757 @default.
- W4225101407 cites W2064661358 @default.
- W4225101407 cites W2067099582 @default.
- W4225101407 cites W2072064154 @default.
- W4225101407 cites W2078135788 @default.
- W4225101407 cites W2086615573 @default.
- W4225101407 cites W2088072251 @default.
- W4225101407 cites W2090998238 @default.
- W4225101407 cites W2094007091 @default.
- W4225101407 cites W2107419359 @default.
- W4225101407 cites W2111968444 @default.
- W4225101407 cites W2115095583 @default.
- W4225101407 cites W2116927564 @default.
- W4225101407 cites W2119084501 @default.
- W4225101407 cites W2120265898 @default.
- W4225101407 cites W2121687483 @default.
- W4225101407 cites W2123878436 @default.
- W4225101407 cites W2126712529 @default.
- W4225101407 cites W2128211763 @default.
- W4225101407 cites W2129928127 @default.
- W4225101407 cites W2135629523 @default.
- W4225101407 cites W2148389554 @default.
- W4225101407 cites W2151048657 @default.
- W4225101407 cites W2151216904 @default.
- W4225101407 cites W2153961293 @default.
- W4225101407 cites W2155783490 @default.
- W4225101407 cites W2157987838 @default.
- W4225101407 cites W2159179104 @default.
- W4225101407 cites W2162071459 @default.
- W4225101407 cites W2164153190 @default.
- W4225101407 cites W2168415226 @default.
- W4225101407 cites W2169373821 @default.
- W4225101407 cites W2171183538 @default.
- W4225101407 cites W2263173111 @default.
- W4225101407 cites W2281172766 @default.
- W4225101407 cites W2336608745 @default.
- W4225101407 cites W2508644210 @default.
- W4225101407 cites W2519909464 @default.