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• W4225101418 abstract "Although the advent of ART has significantly reduced the morbidity and mortality associated with HIV infection, the stable pool of HIV in latently infected cells requires lifelong treatment adherence, with the cessation of ART resulting in rapid reactivation of the virus and productive HIV infection. Therefore, these few cells containing replication-competent HIV, known as the latent HIV reservoir, act as the main barrier to immune clearance and HIV cure. While several strategies involving HIV silencing or its reactivation in latently infected cells for elimination by immune responses have been explored, exciting cell based immune therapies involving genetically engineered T cells expressing synthetic chimeric receptors (CAR T cells) are highly appealing and promising. CAR T cells, in contrast to endogenous cytotoxic T cells, can function independently of MHC to target HIV-infected cells, are efficacious and have demonstrated acceptable safety profiles and long-term persistence in peripheral blood. In this review, we present a comprehensive picture of the current efforts to target the HIV latent reservoir, with a focus on CAR T cell therapies. We highlight the current challenges and advances in this field, while discussing the importance of novel CAR designs in the efforts to find a HIV cure." @default.
• W4225101418 created "2022-04-30" @default.
• W4225101418 creator A5018086400 @default.
• W4225101418 creator A5037264193 @default.
• W4225101418 creator A5055417729 @default.
• W4225101418 creator A5079957640 @default.
• W4225101418 creator A5082310426 @default.
• W4225101418 creator A5088477913 @default.
• W4225101418 date "2022-04-29" @default.
• W4225101418 modified "2023-09-25" @default.
• W4225101418 title "Evolving Strategies to Eliminate the CD4 T Cells HIV Viral Reservoir via CAR T Cell Immunotherapy" @default.
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