Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225101419> ?p ?o ?g. }
- W4225101419 abstract "Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its central importance, the autoantigen repertoire remains largely uncharacterized. Using a novel in vitro antigen delivery method combined with the Human Protein Atlas library, we screened for T cell autoreactivity against 63 CNS-expressed proteins. We identified four previously unreported autoantigens in MS: fatty acid-binding protein 7, prokineticin-2, reticulon-3, and synaptosomal-associated protein 91, which were verified to induce interferon-γ responses in MS in two cohorts. Autoreactive profiles were heterogeneous, and reactivity to several autoantigens was MS-selective. Autoreactive T cells were predominantly CD4+ and human leukocyte antigen-DR restricted. Mouse immunization induced antigen-specific responses and CNS leukocyte infiltration. This represents one of the largest systematic efforts to date in the search for MS autoantigens, demonstrates the heterogeneity of autoreactive profiles, and highlights promising targets for future diagnostic tools and immunomodulatory therapies in MS." @default.
- W4225101419 created "2022-04-30" @default.
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- W4225101419 date "2022-04-29" @default.
- W4225101419 modified "2023-09-30" @default.
- W4225101419 title "Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis" @default.
- W4225101419 cites W1496584596 @default.
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- W4225101419 cites W1899585915 @default.
- W4225101419 cites W1982116697 @default.
- W4225101419 cites W1994743569 @default.
- W4225101419 cites W2002006123 @default.
- W4225101419 cites W2003593782 @default.
- W4225101419 cites W2005170782 @default.
- W4225101419 cites W2010148762 @default.
- W4225101419 cites W2012034410 @default.
- W4225101419 cites W2013725496 @default.
- W4225101419 cites W2016667239 @default.
- W4225101419 cites W2018896468 @default.
- W4225101419 cites W2029097259 @default.
- W4225101419 cites W2030500123 @default.
- W4225101419 cites W2030574465 @default.
- W4225101419 cites W2032658109 @default.
- W4225101419 cites W2040547343 @default.
- W4225101419 cites W2044316391 @default.
- W4225101419 cites W2054254705 @default.
- W4225101419 cites W2055454792 @default.
- W4225101419 cites W2064208546 @default.
- W4225101419 cites W2077812123 @default.
- W4225101419 cites W2081266075 @default.
- W4225101419 cites W2085721994 @default.
- W4225101419 cites W2089608136 @default.
- W4225101419 cites W2091028264 @default.
- W4225101419 cites W2097998535 @default.
- W4225101419 cites W2104949141 @default.
- W4225101419 cites W2108335498 @default.
- W4225101419 cites W2110846578 @default.
- W4225101419 cites W2111785400 @default.
- W4225101419 cites W2119945363 @default.
- W4225101419 cites W2122529630 @default.
- W4225101419 cites W2123743538 @default.
- W4225101419 cites W2126978745 @default.
- W4225101419 cites W2129915891 @default.
- W4225101419 cites W2136266325 @default.
- W4225101419 cites W2148186809 @default.
- W4225101419 cites W2149980541 @default.
- W4225101419 cites W2152236163 @default.
- W4225101419 cites W2154118832 @default.
- W4225101419 cites W2158698691 @default.
- W4225101419 cites W2158714788 @default.
- W4225101419 cites W2218738280 @default.
- W4225101419 cites W2220852412 @default.
- W4225101419 cites W2255924482 @default.
- W4225101419 cites W2274771063 @default.
- W4225101419 cites W2285153579 @default.
- W4225101419 cites W2488762212 @default.
- W4225101419 cites W2515169469 @default.
- W4225101419 cites W2549565855 @default.
- W4225101419 cites W2558488237 @default.
- W4225101419 cites W2560140067 @default.
- W4225101419 cites W2730900075 @default.
- W4225101419 cites W2740350285 @default.
- W4225101419 cites W2760789347 @default.
- W4225101419 cites W2796223745 @default.
- W4225101419 cites W2804442245 @default.
- W4225101419 cites W2889190248 @default.
- W4225101419 cites W2897624078 @default.
- W4225101419 cites W2905137679 @default.
- W4225101419 cites W2916426772 @default.
- W4225101419 cites W2921326361 @default.
- W4225101419 cites W2942560189 @default.