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• W4225101462 abstract "Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been widely used in the Comprehensive in vitro Proarrhythmia Assay (CiPA). The notable difference of the electrophysiological (EP) responses of hiPSC-CMs in serum and serum-free media (SFM) is puzzling and may impact regulatory decision-making on the cardiac safety of candidate drugs in inducing QT prolongation and torsade de pointes (TdP). In this study, we compared the EP responses of hiPSC-CMs to 10 CiPA compounds and moxifloxacin in serum and SFM; explained the potential reason behind the different EP responses—abiotic compound loss to plastic tubes/plates of hydrophobic compounds prepared in SFM; and investigated the impact of compound preparation methods on drug bioavailability in exposure media, which affects the TdP risk prediction of drugs tested in serum-containing and SFM. For assays to be conducted in SFM, awareness of abiotic compound loss of hydrophobic compounds in serum-free preparations is critical for delay repolarization evaluation and data extrapolation from in vitro to in vivo." @default.
• W4225101462 created "2022-04-30" @default.
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• W4225101462 date "2022-04-27" @default.
• W4225101462 modified "2023-09-25" @default.
• W4225101462 title "Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs" @default.
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• W4225101462 doi "https://doi.org/10.1093/toxsci/kfac043" @default.
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