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• W4225101492 endingPage "3050" @default.
• W4225101492 startingPage "3039" @default.
• W4225101492 abstract "Although it is well-established that p53-mediated tumor suppression mainly acts through its ability in transcriptional regulation, the molecular mechanisms of this regulation are not completely understood. Among a number of regulatory modes, acetylation of p53 attracts great interests. p53 was one of the first non-histone proteins found to be functionally regulated by acetylation and deacetylation, and subsequent work has established that reversible acetylation is a general mechanism for regulation of non-histone proteins. Unlike other types of posttranslational modifications occurred during stress responses, the role of p53 acetylation has been recently validated in vivo by using the knock-in mice with both acetylation-defective and acetylation-mimicking p53 mutants. Here, we review the role of acetylation in p53-mediated activities, with a focus on which specific acetylation sites are critical for p53-dependent transcription regulation during tumor suppression and how acetylation of p53 recruits specific “readers” to execute its promoter-specific regulation of different targets. We also discuss the role of p53 acetylation in differentially regulating its classic activities in cell cycle arrest, senescence and apoptosis as well as newly identified unconventional functions such as cell metabolism and ferroptosis." @default.
• W4225101492 created "2022-04-30" @default.
• W4225101492 creator A5015664805 @default.
• W4225101492 creator A5050790863 @default.
• W4225101492 creator A5076488964 @default.
• W4225101492 creator A5077529476 @default.
• W4225101492 creator A5082366029 @default.
• W4225101492 date "2022-04-29" @default.
• W4225101492 modified "2023-10-14" @default.
• W4225101492 title "Deciphering the acetylation code of p53 in transcription regulation and tumor suppression" @default.
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