Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225113048> ?p ?o ?g. }
- W4225113048 endingPage "3137" @default.
- W4225113048 startingPage "3130" @default.
- W4225113048 abstract "In order to identify the molecular pathways governing melanoma and track its progression, the next-generation sequencing (NGS) approach and targeted sequencing of cancer genes were employed. The primary tumor, as well as metastatic tissue, of an 84-year-old patient diagnosed with vulvar melanoma (VM), were investigated. The primary tumor specimen showed multiple somatic mutations in TP53 gene, suggesting its major contribution to melanoma origin. The metastatic sample showed additional alterations, including other melanoma-related genes. Clinical relevancy is postulated to juxtamembrane region instability of KIT gene (c-KIT). We did not identify BRAF or NRAS alterations, which are typical for the most common melanoma pathway-MAPK cascade. However, it should be noted that this is the first report evidencing PDGFRA in melanoma, although its role in triggering VM needs to be further elucidated." @default.
- W4225113048 created "2022-05-01" @default.
- W4225113048 creator A5014702945 @default.
- W4225113048 creator A5017958935 @default.
- W4225113048 creator A5019040298 @default.
- W4225113048 creator A5029056478 @default.
- W4225113048 creator A5032541219 @default.
- W4225113048 creator A5064606551 @default.
- W4225113048 creator A5080556225 @default.
- W4225113048 creator A5080862804 @default.
- W4225113048 creator A5081836071 @default.
- W4225113048 creator A5087002723 @default.
- W4225113048 date "2022-04-29" @default.
- W4225113048 modified "2023-10-14" @default.
- W4225113048 title "Progressing Vulvar Melanoma Caused by Instability in cKIT Juxtamembrane Domain: A Case Report and Review of Literature" @default.
- W4225113048 cites W1511924115 @default.
- W4225113048 cites W1969557760 @default.
- W4225113048 cites W1983787984 @default.
- W4225113048 cites W1988864174 @default.
- W4225113048 cites W2024578614 @default.
- W4225113048 cites W2025447556 @default.
- W4225113048 cites W2026648189 @default.
- W4225113048 cites W2031509306 @default.
- W4225113048 cites W2032487001 @default.
- W4225113048 cites W2046343550 @default.
- W4225113048 cites W2055059484 @default.
- W4225113048 cites W2082927057 @default.
- W4225113048 cites W2090527043 @default.
- W4225113048 cites W2099200814 @default.
- W4225113048 cites W2102763456 @default.
- W4225113048 cites W2151258296 @default.
- W4225113048 cites W2171202246 @default.
- W4225113048 cites W221160362 @default.
- W4225113048 cites W2403081167 @default.
- W4225113048 cites W2511684231 @default.
- W4225113048 cites W2529373149 @default.
- W4225113048 cites W2591748434 @default.
- W4225113048 cites W2624147378 @default.
- W4225113048 cites W2738981269 @default.
- W4225113048 cites W2750001414 @default.
- W4225113048 cites W2751191456 @default.
- W4225113048 cites W2791962996 @default.
- W4225113048 cites W2793817570 @default.
- W4225113048 cites W2802805088 @default.
- W4225113048 cites W2808785641 @default.
- W4225113048 cites W2885885892 @default.
- W4225113048 cites W2888457070 @default.
- W4225113048 cites W2898651421 @default.
- W4225113048 cites W2957235277 @default.
- W4225113048 cites W2958508025 @default.
- W4225113048 cites W3025696252 @default.
- W4225113048 cites W3036926098 @default.
- W4225113048 cites W3043936825 @default.
- W4225113048 cites W3087381804 @default.
- W4225113048 cites W3124574986 @default.
- W4225113048 cites W3134381827 @default.
- W4225113048 cites W3153228158 @default.
- W4225113048 cites W3170274915 @default.
- W4225113048 cites W3174121081 @default.
- W4225113048 cites W3192327720 @default.
- W4225113048 cites W3193443169 @default.
- W4225113048 cites W4206568522 @default.
- W4225113048 cites W4252690463 @default.
- W4225113048 doi "https://doi.org/10.3390/curroncol29050254" @default.
- W4225113048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35621644" @default.
- W4225113048 hasPublicationYear "2022" @default.
- W4225113048 type Work @default.
- W4225113048 citedByCount "1" @default.
- W4225113048 countsByYear W42251130482022 @default.
- W4225113048 crossrefType "journal-article" @default.
- W4225113048 hasAuthorship W4225113048A5014702945 @default.
- W4225113048 hasAuthorship W4225113048A5017958935 @default.
- W4225113048 hasAuthorship W4225113048A5019040298 @default.
- W4225113048 hasAuthorship W4225113048A5029056478 @default.
- W4225113048 hasAuthorship W4225113048A5032541219 @default.
- W4225113048 hasAuthorship W4225113048A5064606551 @default.
- W4225113048 hasAuthorship W4225113048A5080556225 @default.
- W4225113048 hasAuthorship W4225113048A5080862804 @default.
- W4225113048 hasAuthorship W4225113048A5081836071 @default.
- W4225113048 hasAuthorship W4225113048A5087002723 @default.
- W4225113048 hasBestOaLocation W42251130481 @default.
- W4225113048 hasConcept C104317684 @default.
- W4225113048 hasConcept C121608353 @default.
- W4225113048 hasConcept C126322002 @default.
- W4225113048 hasConcept C134305767 @default.
- W4225113048 hasConcept C16930146 @default.
- W4225113048 hasConcept C21790070 @default.
- W4225113048 hasConcept C2775922572 @default.
- W4225113048 hasConcept C2777658100 @default.
- W4225113048 hasConcept C2781186586 @default.
- W4225113048 hasConcept C2781187634 @default.
- W4225113048 hasConcept C37307934 @default.
- W4225113048 hasConcept C501734568 @default.
- W4225113048 hasConcept C502942594 @default.
- W4225113048 hasConcept C54355233 @default.
- W4225113048 hasConcept C555283112 @default.
- W4225113048 hasConcept C71924100 @default.
- W4225113048 hasConcept C86803240 @default.