Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225113793> ?p ?o ?g. }
- W4225113793 endingPage "922" @default.
- W4225113793 startingPage "922" @default.
- W4225113793 abstract "Neisseria gonorrhoeae is the causative agent of the sexually transmitted infection (STI) gonorrhea, with an estimated 87 million annual cases worldwide. N. gonorrhoeae predominantly colonizes the male and female genital tract (FGT). In the FGT, N. gonorrhoeae confronts fluctuating levels of nutrients and oxidative and non-oxidative antimicrobial defenses of the immune system, as well as the resident microbiome. One mechanism utilized by N. gonorrhoeae to adapt to this dynamic FGT niche is to modulate gene expression primarily through DNA-binding transcriptional regulators. Here, we describe the major N. gonorrhoeae transcriptional regulators, genes under their control, and how these regulatory processes lead to pathogenic properties of N. gonorrhoeae during natural infection. We also discuss the current knowledge of the structure, function, and diversity of the FGT microbiome and its influence on gonococcal survival and transcriptional responses orchestrated by its DNA-binding regulators. We conclude with recent multi-omics data and modeling tools and their application to FGT microbiome dynamics. Understanding the strategies utilized by N. gonorrhoeae to regulate gene expression and their impact on the emergent characteristics of this pathogen during infection has the potential to identify new effective strategies to both treat and prevent gonorrhea." @default.
- W4225113793 created "2022-05-01" @default.
- W4225113793 creator A5014892140 @default.
- W4225113793 creator A5022503966 @default.
- W4225113793 creator A5064075585 @default.
- W4225113793 date "2022-04-28" @default.
- W4225113793 modified "2023-10-09" @default.
- W4225113793 title "Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae" @default.
- W4225113793 cites W1539111427 @default.
- W4225113793 cites W1548772785 @default.
- W4225113793 cites W1599138611 @default.
- W4225113793 cites W1868667984 @default.
- W4225113793 cites W1907611525 @default.
- W4225113793 cites W1907810035 @default.
- W4225113793 cites W1919603305 @default.
- W4225113793 cites W1940825484 @default.
- W4225113793 cites W1963615300 @default.
- W4225113793 cites W1964339096 @default.
- W4225113793 cites W1974399308 @default.
- W4225113793 cites W1987226798 @default.
- W4225113793 cites W1988022440 @default.
- W4225113793 cites W1988972551 @default.
- W4225113793 cites W1999691755 @default.
- W4225113793 cites W2003090592 @default.
- W4225113793 cites W2003280642 @default.
- W4225113793 cites W2003954019 @default.
- W4225113793 cites W2004537361 @default.
- W4225113793 cites W2004817967 @default.
- W4225113793 cites W2006977923 @default.
- W4225113793 cites W2010571114 @default.
- W4225113793 cites W2013371150 @default.
- W4225113793 cites W2014234957 @default.
- W4225113793 cites W2014723793 @default.
- W4225113793 cites W2021238963 @default.
- W4225113793 cites W2027297424 @default.
- W4225113793 cites W2027602425 @default.
- W4225113793 cites W2028835702 @default.
- W4225113793 cites W2030100074 @default.
- W4225113793 cites W2031808761 @default.
- W4225113793 cites W2039480695 @default.
- W4225113793 cites W2039529396 @default.
- W4225113793 cites W2040586719 @default.
- W4225113793 cites W2044525257 @default.
- W4225113793 cites W2044678473 @default.
- W4225113793 cites W2045578005 @default.
- W4225113793 cites W2048254575 @default.
- W4225113793 cites W2049778382 @default.
- W4225113793 cites W2053395187 @default.
- W4225113793 cites W2055588579 @default.
- W4225113793 cites W2058686496 @default.
- W4225113793 cites W2062173517 @default.
- W4225113793 cites W2062428121 @default.
- W4225113793 cites W2071263701 @default.
- W4225113793 cites W2071928194 @default.
- W4225113793 cites W2079541485 @default.
- W4225113793 cites W2081304299 @default.
- W4225113793 cites W2081634341 @default.
- W4225113793 cites W2084609640 @default.
- W4225113793 cites W2089384059 @default.
- W4225113793 cites W2090897211 @default.
- W4225113793 cites W2092544263 @default.
- W4225113793 cites W2095739805 @default.
- W4225113793 cites W2096278211 @default.
- W4225113793 cites W2096401127 @default.
- W4225113793 cites W2100686607 @default.
- W4225113793 cites W2101560468 @default.
- W4225113793 cites W2101809821 @default.
- W4225113793 cites W2106658384 @default.
- W4225113793 cites W2112252597 @default.
- W4225113793 cites W2113646062 @default.
- W4225113793 cites W2115780465 @default.
- W4225113793 cites W2116141682 @default.
- W4225113793 cites W2116695192 @default.
- W4225113793 cites W2119148587 @default.
- W4225113793 cites W2120284068 @default.
- W4225113793 cites W2120662592 @default.
- W4225113793 cites W2122221943 @default.
- W4225113793 cites W2124584113 @default.
- W4225113793 cites W2124684065 @default.
- W4225113793 cites W2124869760 @default.
- W4225113793 cites W2127289590 @default.
- W4225113793 cites W2128769815 @default.
- W4225113793 cites W2131206962 @default.
- W4225113793 cites W2139295688 @default.
- W4225113793 cites W2141992747 @default.
- W4225113793 cites W2142808072 @default.
- W4225113793 cites W2143052179 @default.
- W4225113793 cites W2143462323 @default.
- W4225113793 cites W2146545950 @default.
- W4225113793 cites W2150089096 @default.
- W4225113793 cites W2152457726 @default.
- W4225113793 cites W2156640709 @default.
- W4225113793 cites W2157045527 @default.
- W4225113793 cites W2157138422 @default.
- W4225113793 cites W2157142769 @default.
- W4225113793 cites W2160549664 @default.
- W4225113793 cites W2161085554 @default.
- W4225113793 cites W2166825170 @default.