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- W4225113834 abstract "Abstract Chronic inflammation, oxidative stress, and dysregulation of the renin-angiotensin system are closely linked, and their crosstalk commonly contributes to age-related physical and cognitive decline. The primary dementia-protective benefits of Angiotensin II receptor type 1 (AT1R) blockers are believed to arise from systemic effects on blood pressure. However, there is an independently regulated brain-specific renin-angiotensin system. Here, we examined the impact of 4 weeks of oral Losartan treatment on the brains of aged (100 weeks old) IL-10 -/- mice, an animal model of chronic inflammation and frailty. Our data show that aged IL-10 -/- mice have higher AT1R and Nitrotyrosine (oxidative stress marker) levels in their frontal cortex tissue but not in cerebellar or hippocampal tissue compared to age- and sex-matched wild type mice. Losartan treatment for four weeks is associated with lower AT1R protein level, Nitrotyrosine, and Tau protein in the frontal cortex of aged IL-10 -/- mice. Our results highlight the impact of Losartan, an AT1R blocker commonly prescribed for treating high blood pressure, on the brain-specific angiotensin system and AT1R-linked downstream effects such as brain oxidative stress damage and Tau burden in a frailty mouse model." @default.
- W4225113834 created "2022-05-01" @default.
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- W4225113834 date "2022-04-29" @default.
- W4225113834 modified "2023-10-16" @default.
- W4225113834 title "Losartan Mitigates Oxidative Stress in the Brains of Aged and Inflamed IL10 -/- Mice" @default.
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- W4225113834 doi "https://doi.org/10.1093/gerona/glac101" @default.
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