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- W4225114447 abstract "The tumor microenvironment (TME) has been implicated to play an important role in the progression of ovarian cancer. One of the most important components of the TME is tumor associated macrophages (TAMs). Phenotypically, macrophages are broadly categorized as M1 pro-inflammatory or M2 anti-inflammatory, based on the cytokines and chemokines that they secrete. The tumor microenvironment is associated with macrophages of an M2 phenotype which suppress the surrounding immune environment, assist tumor cells in evading immune targeting, and support tumor growth and metastasis. Contrarily, M1 macrophages help mount an immune response against tumors, and are associated with a more favorable prognosis in solid tumors. One of the characteristic indicators of a poor prognosis in ovarian cancer is the overrepresentation of M2-type TAMs. As such, therapeutic modalities targeting TME and TAMs are of increasing interest. Pharmacological approaches to eliminate TAMs, include decreasing macrophage survival and recruitment and increasing phagocytosis, have been underwhelming. Clinical strategies targeting these macrophage subtypes via repolarization to an M1 antitumoral state deserve increasing attention, and may serve as a new modality for immunotherapy." @default.
- W4225114447 created "2022-05-01" @default.
- W4225114447 creator A5016348831 @default.
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- W4225114447 creator A5076253281 @default.
- W4225114447 creator A5081137962 @default.
- W4225114447 date "2022-04-29" @default.
- W4225114447 modified "2023-10-10" @default.
- W4225114447 title "Tumor-Associated Macrophages and Ovarian Cancer: Implications for Therapy" @default.
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