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- W4225116399 abstract "Abstract Background: The association between changes in serum creatinine levels and hypoglycemia during hospitalization was investigated. Methods: This was a retrospective analysis of medical charts. Patients were categorized as having significant change in creatinine (SCIC) when serum creatinine levels rose or dropped ≥0.3 mg/dL from admission values, at any time during their hospitalization. Patients were considered hypoglycemic if they had at least one documented glucose level ≤70 mg/dL during the hospitalization. Multiple logistic, linear and Cox regression analyses were used to ascertain the association between incident SCIC, severity and timing with incident hypoglycemia. Results: Included were 25,400 (mean age 69.9 ± 18.0, 49.3% were males). Rate of SCIC was 22.2%, and 62.2% of them were diagnosed upon admission. Patients with SCIC had higher incidence of hypoglycemia compared to patients without (13.1% vs 4.1%, respectively, p< 0.001). Patients with SCIC had increased risk of hypoglycemia (OR 1.853, 95% CI 1.586-2.166, p<0.001). The magnitude of SCIC was associated with the incidence (OR 1.316, 95% CI 1.197-1.447, p<0.001) and number of events (HR 0.054, 95% CI 0.021-0.087, p=0.001). More than 60% of patients with hypoglycemia had their first event documented during days 0-6 after SCIC occurrence. Of those, the majority of events occurred on day 0-1, and the rate showed a gradual decrease throughout the first 5 days from SCIC occurrence. Results were similar for patients with and without DM. Conclusion: Changes in creatinine during hospitalization may cause hypoglycemia among patients admitted to internal medicine departments, regardless of DM status." @default.
- W4225116399 created "2022-05-01" @default.
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- W4225116399 date "2022-04-29" @default.
- W4225116399 modified "2023-10-16" @default.
- W4225116399 title "Changes in serum creatinine may cause hypoglycemia among non-critically ill patients admitted to internal medicine units" @default.
- W4225116399 doi "https://doi.org/10.21203/rs.3.rs-1567006/v1" @default.
- W4225116399 hasPublicationYear "2022" @default.
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