Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225116988> ?p ?o ?g. }
- W4225116988 abstract "Chrysin (CHR) is a flavonoid with extensive pharmacological activity. The molecular formula of CHR is C15 H10 O4 . CHR is reported to have antioxidative, antitumour and antiviral functions. To evaluate its potential function as a vaccine adjuvant, we prepared a melanoma vaccine using a soluble protein extract of B16F10 melanoma cells as antigen and CHR as an adjuvant. The melanoma model was developed after two immunizations, and it was discovered that combining B16F10 soluble protein antigen-mixed CHR vaccine could inhibit tumour growth in the mouse model, and the overall survival rate was higher than that of the B16F10 antigen vaccine alone. In vivo and in vitro experiments were conducted to determine whether CHR functioned as an adjuvant by activating antigen-presenting cells (APCs). We discovered that CHR activated APCs both in vivo and in vitro and may enhance Th1 cell function by activating the IL12-STAT4 signal pathway, thereby enhancing the antitumour response of cytotoxic T lymphocytes (CTLs) in vivo. Next, to verify the critical role of CD8+ T cells in suppressing melanoma development, we transplanted CD8+ T cells from immunized mice to B16F10 tumour-bearing mice and discovered that the survival rate of tumour-bearing mice was significantly prolonged. In summary, our experimental results indicate that CHR can be used as a potential adjuvant to enhance antigen immunogenicity, inhibit B16F10 tumour growth in mice and improve tumour immune response." @default.
- W4225116988 created "2022-05-01" @default.
- W4225116988 creator A5002545500 @default.
- W4225116988 creator A5003168303 @default.
- W4225116988 creator A5024016470 @default.
- W4225116988 creator A5028607066 @default.
- W4225116988 creator A5034730284 @default.
- W4225116988 creator A5035520440 @default.
- W4225116988 creator A5037121594 @default.
- W4225116988 creator A5039724350 @default.
- W4225116988 creator A5055899968 @default.
- W4225116988 creator A5056803946 @default.
- W4225116988 creator A5072861069 @default.
- W4225116988 creator A5077904151 @default.
- W4225116988 creator A5082539182 @default.
- W4225116988 date "2022-05-13" @default.
- W4225116988 modified "2023-10-14" @default.
- W4225116988 title "Chrysin enhances antitumour immunity response through the <scp>IL‐12‐STAT4</scp> signal pathway in the <scp>B16F10</scp> melanoma mouse model" @default.
- W4225116988 cites W2018125657 @default.
- W4225116988 cites W2029884055 @default.
- W4225116988 cites W2052817467 @default.
- W4225116988 cites W2059385530 @default.
- W4225116988 cites W2154203858 @default.
- W4225116988 cites W2160694273 @default.
- W4225116988 cites W2265419075 @default.
- W4225116988 cites W2308389558 @default.
- W4225116988 cites W2506616866 @default.
- W4225116988 cites W2518538521 @default.
- W4225116988 cites W2593186433 @default.
- W4225116988 cites W2605233023 @default.
- W4225116988 cites W2611953884 @default.
- W4225116988 cites W2724154348 @default.
- W4225116988 cites W2733865167 @default.
- W4225116988 cites W2740637641 @default.
- W4225116988 cites W2762347490 @default.
- W4225116988 cites W2762602728 @default.
- W4225116988 cites W2764009809 @default.
- W4225116988 cites W2766745368 @default.
- W4225116988 cites W2772049918 @default.
- W4225116988 cites W2789287894 @default.
- W4225116988 cites W2805352540 @default.
- W4225116988 cites W2884810714 @default.
- W4225116988 cites W2889892812 @default.
- W4225116988 cites W2901746667 @default.
- W4225116988 cites W2904099327 @default.
- W4225116988 cites W2904900941 @default.
- W4225116988 cites W2905853674 @default.
- W4225116988 cites W2932851203 @default.
- W4225116988 cites W2943197912 @default.
- W4225116988 cites W2943793201 @default.
- W4225116988 cites W2945777288 @default.
- W4225116988 cites W2950011075 @default.
- W4225116988 cites W2966710588 @default.
- W4225116988 cites W2966720907 @default.
- W4225116988 cites W2967217932 @default.
- W4225116988 cites W2971741532 @default.
- W4225116988 cites W2986928599 @default.
- W4225116988 cites W3001016710 @default.
- W4225116988 cites W3048641542 @default.
- W4225116988 cites W3093992907 @default.
- W4225116988 cites W3132787342 @default.
- W4225116988 cites W3169607232 @default.
- W4225116988 cites W4244506835 @default.
- W4225116988 doi "https://doi.org/10.1111/sji.13177" @default.
- W4225116988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35484925" @default.
- W4225116988 hasPublicationYear "2022" @default.
- W4225116988 type Work @default.
- W4225116988 citedByCount "5" @default.
- W4225116988 countsByYear W42251169882022 @default.
- W4225116988 countsByYear W42251169882023 @default.
- W4225116988 crossrefType "journal-article" @default.
- W4225116988 hasAuthorship W4225116988A5002545500 @default.
- W4225116988 hasAuthorship W4225116988A5003168303 @default.
- W4225116988 hasAuthorship W4225116988A5024016470 @default.
- W4225116988 hasAuthorship W4225116988A5028607066 @default.
- W4225116988 hasAuthorship W4225116988A5034730284 @default.
- W4225116988 hasAuthorship W4225116988A5035520440 @default.
- W4225116988 hasAuthorship W4225116988A5037121594 @default.
- W4225116988 hasAuthorship W4225116988A5039724350 @default.
- W4225116988 hasAuthorship W4225116988A5055899968 @default.
- W4225116988 hasAuthorship W4225116988A5056803946 @default.
- W4225116988 hasAuthorship W4225116988A5072861069 @default.
- W4225116988 hasAuthorship W4225116988A5077904151 @default.
- W4225116988 hasAuthorship W4225116988A5082539182 @default.
- W4225116988 hasConcept C147483822 @default.
- W4225116988 hasConcept C150903083 @default.
- W4225116988 hasConcept C154317977 @default.
- W4225116988 hasConcept C167672396 @default.
- W4225116988 hasConcept C185592680 @default.
- W4225116988 hasConcept C202751555 @default.
- W4225116988 hasConcept C203014093 @default.
- W4225116988 hasConcept C207001950 @default.
- W4225116988 hasConcept C2777658100 @default.
- W4225116988 hasConcept C2777863537 @default.
- W4225116988 hasConcept C2778004101 @default.
- W4225116988 hasConcept C2779054382 @default.
- W4225116988 hasConcept C2779478871 @default.
- W4225116988 hasConcept C2780868878 @default.
- W4225116988 hasConcept C502942594 @default.
- W4225116988 hasConcept C55493867 @default.