Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225117008> ?p ?o ?g. }
- W4225117008 abstract "Abstract Neurovascular-glymphatic dysfunction plays an important role in Alzheimer’s disease and has been analyzed mainly in association with amyloid-beta (Aβ) pathology. The neurovascular-glymphatic link with tauopathies has not been well elucidated. Here, we aimed to investigate the alterations in the neurovasculature and map the aquaporin 4 (AQP4) distribution and depolarization associated with tau and Aβ. Perfusion, susceptibility weighted imaging and structural magnetic resonance imaging (MRI) were performed in the pR5 P301L mouse model of 4-repeat tau and the arcAβ mouse model of amyloidosis. Immunofluorescence staining was performed using antibodies against AQP4, CD31, astroglia (GFAP, s100β), phospho-tau (AT-8) and Aβ (6E10) in brain tissue slices from P301L, arcAβ and nontransgenic mice. P301L mice showed regional atrophy, preserved cerebral blood flow and reduced cerebral vessel density compared to nontransgenic mice, while arcAβ mice showed cerebral microbleeds and reduced cerebral vessel density. AQP4 depolarization and peri-tau enrichment in the hippocampus and increased AQP4 levels in the forebrain and hippocampus were detected in P301L mice compared to nontransgenic mice. In comparison, cortical AQP4 depolarization and cortical/hippocampal peri-plaque increases were observed in arcAβ mice. Increased s100β-GFAP fluorescence intensities indicative of reactive astrocytes were detected surrounding tau inclusions in P301L mice and Aβ plaques in arcAβ mice. In conclusion, we observed a divergent region-specific AQP4 increase and association with phospho-tau and Aβ pathologies." @default.
- W4225117008 created "2022-05-01" @default.
- W4225117008 creator A5016313389 @default.
- W4225117008 creator A5033070576 @default.
- W4225117008 creator A5038850610 @default.
- W4225117008 creator A5045845330 @default.
- W4225117008 creator A5048324375 @default.
- W4225117008 creator A5051431217 @default.
- W4225117008 creator A5056241598 @default.
- W4225117008 creator A5061554709 @default.
- W4225117008 creator A5082319905 @default.
- W4225117008 date "2022-04-27" @default.
- W4225117008 modified "2023-10-16" @default.
- W4225117008 title "Aquaporin 4 is differentially increased and depolarized in association with tau and amyloid-beta" @default.
- W4225117008 cites W106908657 @default.
- W4225117008 cites W1767010801 @default.
- W4225117008 cites W1923535990 @default.
- W4225117008 cites W1969125278 @default.
- W4225117008 cites W1975389666 @default.
- W4225117008 cites W1994120645 @default.
- W4225117008 cites W2006035554 @default.
- W4225117008 cites W2006696380 @default.
- W4225117008 cites W2023890923 @default.
- W4225117008 cites W2024720661 @default.
- W4225117008 cites W2024955728 @default.
- W4225117008 cites W2035156043 @default.
- W4225117008 cites W2041824340 @default.
- W4225117008 cites W2047679742 @default.
- W4225117008 cites W2055004096 @default.
- W4225117008 cites W2060701169 @default.
- W4225117008 cites W2061570360 @default.
- W4225117008 cites W2070251027 @default.
- W4225117008 cites W2084009613 @default.
- W4225117008 cites W2094785614 @default.
- W4225117008 cites W2095963715 @default.
- W4225117008 cites W2096230518 @default.
- W4225117008 cites W2100314515 @default.
- W4225117008 cites W2105704879 @default.
- W4225117008 cites W2134463696 @default.
- W4225117008 cites W2157816812 @default.
- W4225117008 cites W2164273040 @default.
- W4225117008 cites W2167183660 @default.
- W4225117008 cites W2258002535 @default.
- W4225117008 cites W2316559971 @default.
- W4225117008 cites W2326077285 @default.
- W4225117008 cites W2474981734 @default.
- W4225117008 cites W2559691789 @default.
- W4225117008 cites W2580383152 @default.
- W4225117008 cites W2586972387 @default.
- W4225117008 cites W2616216465 @default.
- W4225117008 cites W2619053878 @default.
- W4225117008 cites W2725377723 @default.
- W4225117008 cites W2748477620 @default.
- W4225117008 cites W2767482362 @default.
- W4225117008 cites W2769140026 @default.
- W4225117008 cites W2783539126 @default.
- W4225117008 cites W2784733460 @default.
- W4225117008 cites W2785763878 @default.
- W4225117008 cites W2795294714 @default.
- W4225117008 cites W2795893566 @default.
- W4225117008 cites W2796983933 @default.
- W4225117008 cites W2797451001 @default.
- W4225117008 cites W2801863964 @default.
- W4225117008 cites W2851624943 @default.
- W4225117008 cites W2883628966 @default.
- W4225117008 cites W2885068912 @default.
- W4225117008 cites W2885225461 @default.
- W4225117008 cites W2886287396 @default.
- W4225117008 cites W2890806217 @default.
- W4225117008 cites W2890865075 @default.
- W4225117008 cites W2895939677 @default.
- W4225117008 cites W2901166225 @default.
- W4225117008 cites W2905484748 @default.
- W4225117008 cites W2912954741 @default.
- W4225117008 cites W2914385671 @default.
- W4225117008 cites W2921783885 @default.
- W4225117008 cites W2944666647 @default.
- W4225117008 cites W2952481429 @default.
- W4225117008 cites W2952497563 @default.
- W4225117008 cites W2980716100 @default.
- W4225117008 cites W3000093244 @default.
- W4225117008 cites W3003588588 @default.
- W4225117008 cites W3004827233 @default.
- W4225117008 cites W3005955078 @default.
- W4225117008 cites W3007980995 @default.
- W4225117008 cites W3012525540 @default.
- W4225117008 cites W3018541302 @default.
- W4225117008 cites W3022402848 @default.
- W4225117008 cites W3024439707 @default.
- W4225117008 cites W3025276239 @default.
- W4225117008 cites W3025374083 @default.
- W4225117008 cites W3025780063 @default.
- W4225117008 cites W3029306449 @default.
- W4225117008 cites W3036808974 @default.
- W4225117008 cites W3038112026 @default.
- W4225117008 cites W3042129895 @default.
- W4225117008 cites W3044277410 @default.
- W4225117008 cites W3044413849 @default.
- W4225117008 cites W3048203223 @default.
- W4225117008 cites W3048881984 @default.