Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225120997> ?p ?o ?g. }
- W4225120997 abstract "Hypothermic machine perfusion (HMP) has become the new gold standard in clinical donor kidney preservation and a promising novel strategy in higher risk donor livers in several countries. As shown by meta-analysis for the kidney, HMP decreases the risk of delayed graft function (DGF) and improves graft survival. For the liver, HMP immediately prior to transplantation may reduce the chance of early allograft dysfunction (EAD) and reduce ischemic sequelae in the biliary tract. Ischemia-reperfusion injury (IRI), unavoidable during transplantation, can lead to massive cell death and is one of the main causes for DGF, EAD or longer term impact. Molecular mechanisms that are affected in IRI include levels of hypoxia inducible factor (HIF), induction of cell death, endothelial dysfunction and immune responses. In this review we have summarized and discussed mechanisms on how HMP can ameliorate IRI. Better insight into how HMP influences IRI in kidney and liver transplantation may lead to new therapies and improved transplant outcomes." @default.
- W4225120997 created "2022-05-01" @default.
- W4225120997 creator A5023209801 @default.
- W4225120997 creator A5037152123 @default.
- W4225120997 creator A5067650391 @default.
- W4225120997 date "2022-04-29" @default.
- W4225120997 modified "2023-09-25" @default.
- W4225120997 title "The Effect of Hypothermic Machine Perfusion to Ameliorate Ischemia-Reperfusion Injury in Donor Organs" @default.
- W4225120997 cites W1481799686 @default.
- W4225120997 cites W1529930859 @default.
- W4225120997 cites W1587820444 @default.
- W4225120997 cites W1674731755 @default.
- W4225120997 cites W1907385176 @default.
- W4225120997 cites W1969693194 @default.
- W4225120997 cites W1970081212 @default.
- W4225120997 cites W1974804636 @default.
- W4225120997 cites W1981245593 @default.
- W4225120997 cites W1982952028 @default.
- W4225120997 cites W1985970823 @default.
- W4225120997 cites W1987226635 @default.
- W4225120997 cites W1988868193 @default.
- W4225120997 cites W1990460115 @default.
- W4225120997 cites W1990607537 @default.
- W4225120997 cites W1994308603 @default.
- W4225120997 cites W2001456553 @default.
- W4225120997 cites W2005044790 @default.
- W4225120997 cites W2009274730 @default.
- W4225120997 cites W2013127121 @default.
- W4225120997 cites W2018563185 @default.
- W4225120997 cites W2019273089 @default.
- W4225120997 cites W2020379784 @default.
- W4225120997 cites W2022451432 @default.
- W4225120997 cites W2025955916 @default.
- W4225120997 cites W2026138134 @default.
- W4225120997 cites W2035170959 @default.
- W4225120997 cites W2035898183 @default.
- W4225120997 cites W2037857730 @default.
- W4225120997 cites W2045171661 @default.
- W4225120997 cites W2053428121 @default.
- W4225120997 cites W2054737428 @default.
- W4225120997 cites W2068529705 @default.
- W4225120997 cites W2076378891 @default.
- W4225120997 cites W2078773135 @default.
- W4225120997 cites W2088077435 @default.
- W4225120997 cites W2089549504 @default.
- W4225120997 cites W2094764776 @default.
- W4225120997 cites W2105279526 @default.
- W4225120997 cites W2109562613 @default.
- W4225120997 cites W2110796758 @default.
- W4225120997 cites W2111395199 @default.
- W4225120997 cites W2113457862 @default.
- W4225120997 cites W2125881367 @default.
- W4225120997 cites W2131897198 @default.
- W4225120997 cites W2134316956 @default.
- W4225120997 cites W2134979684 @default.
- W4225120997 cites W2138509714 @default.
- W4225120997 cites W2139552156 @default.
- W4225120997 cites W2140655321 @default.
- W4225120997 cites W2143461874 @default.
- W4225120997 cites W2145249725 @default.
- W4225120997 cites W2145398823 @default.
- W4225120997 cites W2146234609 @default.
- W4225120997 cites W2147356908 @default.
- W4225120997 cites W2149008701 @default.
- W4225120997 cites W2150201934 @default.
- W4225120997 cites W2156951651 @default.
- W4225120997 cites W2156964549 @default.
- W4225120997 cites W2160607876 @default.
- W4225120997 cites W2165423688 @default.
- W4225120997 cites W2167597689 @default.
- W4225120997 cites W2167822422 @default.
- W4225120997 cites W2181254318 @default.
- W4225120997 cites W2257214644 @default.
- W4225120997 cites W2264713473 @default.
- W4225120997 cites W2273649406 @default.
- W4225120997 cites W2316698463 @default.
- W4225120997 cites W2330980610 @default.
- W4225120997 cites W2336196789 @default.
- W4225120997 cites W2341113799 @default.
- W4225120997 cites W2346552090 @default.
- W4225120997 cites W2388295221 @default.
- W4225120997 cites W2405846797 @default.
- W4225120997 cites W2417443353 @default.
- W4225120997 cites W2503209769 @default.
- W4225120997 cites W2509878167 @default.
- W4225120997 cites W2511932431 @default.
- W4225120997 cites W2588975112 @default.
- W4225120997 cites W2595069180 @default.
- W4225120997 cites W2595092778 @default.
- W4225120997 cites W2604465410 @default.
- W4225120997 cites W2609905737 @default.
- W4225120997 cites W2617629406 @default.
- W4225120997 cites W2624152115 @default.
- W4225120997 cites W2741022012 @default.
- W4225120997 cites W2753905371 @default.
- W4225120997 cites W2754468979 @default.
- W4225120997 cites W2755845005 @default.
- W4225120997 cites W2766256658 @default.
- W4225120997 cites W2771321625 @default.
- W4225120997 cites W2778210587 @default.