Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225124636> ?p ?o ?g. }
- W4225124636 abstract "Abstract Ewing’s sarcoma has a poor prognosis and high metastasis rate; thus, it is critical to explore prognostic biomarkers of m6A-related genes. Two datasets were downloaded from the Gene Expression Omnibus database, m6A-related genes were extracted, and prognostic models were constructed using the least absolute shrinkage and selection operator and multivariate COX regression analyses. Immune cell composition and drug sensitivity analyses were performed, and our analysis was validated using laboratory methods of immunohistochemical specific staining and qRT-PCR. Ewing’s sarcoma prognostic model demonstrated that the survival rate of cases in the high-risk group was much lower than that of the low-risk group. Naïve B cells, macrophages M0, macrophages M1, and resting mast cells are closely associated with Ewing’s sarcoma. METTL14 and YTHDF2 are strongly associated with multiple drug sensitivity. Immunohistochemical specific staining revealed higher expression of both METTL14 and YTHDF2 in Ewing’s sarcoma than in the paraneoplastic tissues. The results of qRT-PCR showed that METTL14 expression was significantly higher in both ES cell lines than in the control cell line. The prognostic model constructed using m6A-related genes METTL14 and TYHDF2, can be a potential prognostic biomarker for Ewing’s sarcoma, with the survival rate of cases in the high-risk group being much lower than that of the low-risk group." @default.
- W4225124636 created "2022-05-01" @default.
- W4225124636 creator A5000080255 @default.
- W4225124636 creator A5006257239 @default.
- W4225124636 creator A5019560977 @default.
- W4225124636 creator A5023403656 @default.
- W4225124636 creator A5027226632 @default.
- W4225124636 creator A5033731029 @default.
- W4225124636 creator A5036134386 @default.
- W4225124636 creator A5045551132 @default.
- W4225124636 creator A5046891007 @default.
- W4225124636 creator A5053911985 @default.
- W4225124636 creator A5056428506 @default.
- W4225124636 creator A5058544003 @default.
- W4225124636 creator A5079699735 @default.
- W4225124636 date "2022-04-29" @default.
- W4225124636 modified "2023-10-03" @default.
- W4225124636 title "Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing’s sarcoma" @default.
- W4225124636 cites W1577941245 @default.
- W4225124636 cites W1985987855 @default.
- W4225124636 cites W2042699075 @default.
- W4225124636 cites W2119933251 @default.
- W4225124636 cites W2120280351 @default.
- W4225124636 cites W2512784295 @default.
- W4225124636 cites W2775006908 @default.
- W4225124636 cites W2776540408 @default.
- W4225124636 cites W2788142646 @default.
- W4225124636 cites W2808057888 @default.
- W4225124636 cites W2808825101 @default.
- W4225124636 cites W2886253007 @default.
- W4225124636 cites W2893071097 @default.
- W4225124636 cites W2903814629 @default.
- W4225124636 cites W2922969171 @default.
- W4225124636 cites W2972933339 @default.
- W4225124636 cites W2977905919 @default.
- W4225124636 cites W2990844810 @default.
- W4225124636 cites W2992958546 @default.
- W4225124636 cites W3010860369 @default.
- W4225124636 cites W3015901604 @default.
- W4225124636 cites W3022834896 @default.
- W4225124636 cites W3033594250 @default.
- W4225124636 cites W3037477427 @default.
- W4225124636 cites W3039633408 @default.
- W4225124636 cites W3045914854 @default.
- W4225124636 cites W3048712150 @default.
- W4225124636 cites W3081506412 @default.
- W4225124636 cites W3081692890 @default.
- W4225124636 cites W3082537053 @default.
- W4225124636 cites W3083725442 @default.
- W4225124636 cites W3085163366 @default.
- W4225124636 cites W3092369420 @default.
- W4225124636 cites W3102455986 @default.
- W4225124636 cites W3103634428 @default.
- W4225124636 cites W3112898749 @default.
- W4225124636 cites W3113308784 @default.
- W4225124636 cites W3117599110 @default.
- W4225124636 cites W3177498423 @default.
- W4225124636 doi "https://doi.org/10.1038/s41598-022-06744-0" @default.
- W4225124636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35487915" @default.
- W4225124636 hasPublicationYear "2022" @default.
- W4225124636 type Work @default.
- W4225124636 citedByCount "2" @default.
- W4225124636 countsByYear W42251246362023 @default.
- W4225124636 crossrefType "journal-article" @default.
- W4225124636 hasAuthorship W4225124636A5000080255 @default.
- W4225124636 hasAuthorship W4225124636A5006257239 @default.
- W4225124636 hasAuthorship W4225124636A5019560977 @default.
- W4225124636 hasAuthorship W4225124636A5023403656 @default.
- W4225124636 hasAuthorship W4225124636A5027226632 @default.
- W4225124636 hasAuthorship W4225124636A5033731029 @default.
- W4225124636 hasAuthorship W4225124636A5036134386 @default.
- W4225124636 hasAuthorship W4225124636A5045551132 @default.
- W4225124636 hasAuthorship W4225124636A5046891007 @default.
- W4225124636 hasAuthorship W4225124636A5053911985 @default.
- W4225124636 hasAuthorship W4225124636A5056428506 @default.
- W4225124636 hasAuthorship W4225124636A5058544003 @default.
- W4225124636 hasAuthorship W4225124636A5079699735 @default.
- W4225124636 hasBestOaLocation W42251246361 @default.
- W4225124636 hasConcept C10515644 @default.
- W4225124636 hasConcept C126322002 @default.
- W4225124636 hasConcept C142724271 @default.
- W4225124636 hasConcept C143998085 @default.
- W4225124636 hasConcept C203014093 @default.
- W4225124636 hasConcept C204232928 @default.
- W4225124636 hasConcept C2777586341 @default.
- W4225124636 hasConcept C2778256501 @default.
- W4225124636 hasConcept C502942594 @default.
- W4225124636 hasConcept C50382708 @default.
- W4225124636 hasConcept C71924100 @default.
- W4225124636 hasConcept C86803240 @default.
- W4225124636 hasConceptScore W4225124636C10515644 @default.
- W4225124636 hasConceptScore W4225124636C126322002 @default.
- W4225124636 hasConceptScore W4225124636C142724271 @default.
- W4225124636 hasConceptScore W4225124636C143998085 @default.
- W4225124636 hasConceptScore W4225124636C203014093 @default.
- W4225124636 hasConceptScore W4225124636C204232928 @default.
- W4225124636 hasConceptScore W4225124636C2777586341 @default.
- W4225124636 hasConceptScore W4225124636C2778256501 @default.
- W4225124636 hasConceptScore W4225124636C502942594 @default.
- W4225124636 hasConceptScore W4225124636C50382708 @default.