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- W4225125290 abstract "ABSTRACT Recent evidence suggests that the coding potential of the mitogenome is underestimated. We found a downstream alternative ATG initiation codon in the +3 reading frame of the human mitochondrial nd4 gene. This newly characterized alternative open reading frame (altORF) encodes a 99-amino acids long polypeptide, MTALTND4, which is conserved in primates. This small protein is localized in mitochondria and cytoplasm and is also found in the plasma, and it impacts mitochondrial physiology. Alternative mitochondrial peptides such as MTALTND4 may offer a new framework for the investigation of mitochondrial functions and diseases." @default.
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- W4225125290 date "2022-04-28" @default.
- W4225125290 modified "2023-10-01" @default.
- W4225125290 title "MTALTND4, a second protein coded by <i>nd4</i> impacts mitochondrial bioenergetics" @default.
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- W4225125290 doi "https://doi.org/10.1101/2022.04.28.489924" @default.
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