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- W4225132400 endingPage "026056" @default.
- W4225132400 startingPage "026056" @default.
- W4225132400 abstract "Objective.Diagnosing epilepsy still requires visual interpretation of electroencephalography (EEG) and magnetoencephalography (MEG) by specialists, which prevents quantification and standardization of diagnosis. Previous studies proposed automated diagnosis by combining various features from EEG and MEG, such as relative power (Power) and functional connectivity (FC). However, the usefulness of interictal phase-amplitude coupling (PAC) in diagnosing epilepsy is still unknown. We hypothesized that resting-state PAC would be different for patients with epilepsy in the interictal state and for healthy participants such that it would improve discrimination between the groups.Approach.We obtained resting-state MEG and magnetic resonance imaging (MRI) in 90 patients with epilepsy during their preoperative evaluation and in 90 healthy participants. We used the cortical currents estimated from MEG and MRI to calculate Power in theδ(1-3 Hz),θ(4-7 Hz),α(8-13 Hz),β(13-30 Hz), lowγ(35-55 Hz), and highγ(65-90 Hz) bands and FC in theθband. PAC was evaluated using the synchronization index (SI) for eight frequency band pairs: the phases ofδ, θ, α, andβand the amplitudes of low and highγ. First, we compared the mean SI values for the patients with epilepsy and the healthy participants. Then, using features such as PAC, Power, FC, and features extracted by deep learning (DL) individually or combined, we tested whether PAC improves discrimination accuracy for the two groups.Main results.The mean SI values were significantly different for the patients with epilepsy and the healthy participants. The SI value difference was highest forθ/lowγin the temporal lobe. Discrimination accuracy was the highest, at 90%, using the combination of PAC and DL.Significance.Abnormal PAC characterized the patients with epilepsy in the interictal state compared with the healthy participants, potentially improving the discrimination of epilepsy." @default.
- W4225132400 created "2022-05-01" @default.
- W4225132400 creator A5022807823 @default.
- W4225132400 creator A5025926397 @default.
- W4225132400 creator A5032147102 @default.
- W4225132400 creator A5040732498 @default.
- W4225132400 creator A5046288905 @default.
- W4225132400 creator A5054045156 @default.
- W4225132400 date "2022-04-01" @default.
- W4225132400 modified "2023-09-27" @default.
- W4225132400 title "Abnormal phase–amplitude coupling characterizes the interictal state in epilepsy" @default.
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- W4225132400 doi "https://doi.org/10.1088/1741-2552/ac64c4" @default.