Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225137247> ?p ?o ?g. }
- W4225137247 endingPage "846.e10" @default.
- W4225137247 startingPage "827" @default.
- W4225137247 abstract "Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance. Bacterial persistence occurred in granulomas enriched for mast, endothelial, fibroblast, and plasma cells, signaling amongst themselves via type 2 immunity and wound-healing pathways. Granulomas that drove bacterial control were characterized by cellular ecosystems enriched for type 1-type 17, stem-like, and cytotoxic T cells engaged in pro-inflammatory signaling networks involving diverse cell populations. Granulomas that arose later in infection displayed functional characteristics of restrictive granulomas and were more capable of killing Mtb. Our results define the complex multicellular ecosystems underlying (lack of) granuloma resolution and highlight host immune targets that can be leveraged to develop new vaccine and therapeutic strategies for TB." @default.
- W4225137247 created "2022-05-01" @default.
- W4225137247 creator A5001076999 @default.
- W4225137247 creator A5003573761 @default.
- W4225137247 creator A5008493016 @default.
- W4225137247 creator A5010808044 @default.
- W4225137247 creator A5013050333 @default.
- W4225137247 creator A5015896696 @default.
- W4225137247 creator A5018357461 @default.
- W4225137247 creator A5020748070 @default.
- W4225137247 creator A5020926236 @default.
- W4225137247 creator A5026099371 @default.
- W4225137247 creator A5028293023 @default.
- W4225137247 creator A5032625271 @default.
- W4225137247 creator A5033071848 @default.
- W4225137247 creator A5036829394 @default.
- W4225137247 creator A5038595890 @default.
- W4225137247 creator A5038934486 @default.
- W4225137247 creator A5042316021 @default.
- W4225137247 creator A5043059063 @default.
- W4225137247 creator A5043125458 @default.
- W4225137247 creator A5044078921 @default.
- W4225137247 creator A5049001520 @default.
- W4225137247 creator A5053002143 @default.
- W4225137247 creator A5053217340 @default.
- W4225137247 creator A5053359412 @default.
- W4225137247 creator A5055734549 @default.
- W4225137247 creator A5055778381 @default.
- W4225137247 creator A5056662069 @default.
- W4225137247 creator A5059738659 @default.
- W4225137247 creator A5062756669 @default.
- W4225137247 creator A5063430862 @default.
- W4225137247 creator A5064372714 @default.
- W4225137247 creator A5065007055 @default.
- W4225137247 creator A5070404848 @default.
- W4225137247 creator A5070565529 @default.
- W4225137247 creator A5072162720 @default.
- W4225137247 creator A5074378859 @default.
- W4225137247 creator A5080075194 @default.
- W4225137247 creator A5081182545 @default.
- W4225137247 creator A5083743078 @default.
- W4225137247 creator A5086413795 @default.
- W4225137247 creator A5087831220 @default.
- W4225137247 creator A5088642282 @default.
- W4225137247 creator A5088687956 @default.
- W4225137247 date "2022-05-01" @default.
- W4225137247 modified "2023-10-17" @default.
- W4225137247 title "Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control" @default.
- W4225137247 cites W1483831487 @default.
- W4225137247 cites W1498486243 @default.
- W4225137247 cites W1531876501 @default.
- W4225137247 cites W1572743872 @default.
- W4225137247 cites W1764569853 @default.
- W4225137247 cites W1891716637 @default.
- W4225137247 cites W1901355048 @default.
- W4225137247 cites W1965685424 @default.
- W4225137247 cites W1969503044 @default.
- W4225137247 cites W1971041641 @default.
- W4225137247 cites W1973720948 @default.
- W4225137247 cites W1979478578 @default.
- W4225137247 cites W1981824586 @default.
- W4225137247 cites W1985987855 @default.
- W4225137247 cites W1986514504 @default.
- W4225137247 cites W1999213270 @default.
- W4225137247 cites W2007435978 @default.
- W4225137247 cites W2009324985 @default.
- W4225137247 cites W2010457001 @default.
- W4225137247 cites W2015609239 @default.
- W4225137247 cites W2024362866 @default.
- W4225137247 cites W2026190085 @default.
- W4225137247 cites W2027189611 @default.
- W4225137247 cites W2028350521 @default.
- W4225137247 cites W2043776488 @default.
- W4225137247 cites W2044757050 @default.
- W4225137247 cites W2046864860 @default.
- W4225137247 cites W2048500103 @default.
- W4225137247 cites W2048884877 @default.
- W4225137247 cites W2063710887 @default.
- W4225137247 cites W2065001185 @default.
- W4225137247 cites W2065049812 @default.
- W4225137247 cites W2071876961 @default.
- W4225137247 cites W2073412176 @default.
- W4225137247 cites W2083568238 @default.
- W4225137247 cites W2085980489 @default.
- W4225137247 cites W2089532656 @default.
- W4225137247 cites W2092448486 @default.
- W4225137247 cites W2099398229 @default.
- W4225137247 cites W2099939307 @default.
- W4225137247 cites W2100990607 @default.
- W4225137247 cites W2102158172 @default.
- W4225137247 cites W2102212449 @default.
- W4225137247 cites W2104048810 @default.
- W4225137247 cites W2106938658 @default.
- W4225137247 cites W2108210947 @default.
- W4225137247 cites W2109531704 @default.
- W4225137247 cites W2111023292 @default.
- W4225137247 cites W2117340681 @default.
- W4225137247 cites W2118033114 @default.