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- W4225146345 endingPage "2194" @default.
- W4225146345 startingPage "2194" @default.
- W4225146345 abstract "Telomeres are DNA-protein complexes that protect eukaryotic chromosome ends from being erroneously repaired by the DNA damage repair system, and the length of telomeres indicates the replicative potential of the cell. Telomeres shorten during each division of the cell, resulting in telomeric damage and replicative senescence. Tumor cells tend to ensure cell proliferation potential and genomic stability by activating telomere maintenance mechanisms (TMMs) for telomere lengthening. The alternative lengthening of telomeres (ALT) pathway is the most frequently activated TMM in tumors of mesenchymal and neuroepithelial origin, and ALT also frequently occurs during experimental cellular immortalization of mesenchymal cells. ALT is a process that relies on homologous recombination (HR) to elongate telomeres. However, some processes in the ALT mechanism remain poorly understood. Here, we review the most recent understanding of ALT mechanisms and processes, which may help us to better understand how the ALT pathway is activated in cancer cells and determine the potential therapeutic targets in ALT pathway-stabilized tumors." @default.
- W4225146345 created "2022-05-01" @default.
- W4225146345 creator A5012503537 @default.
- W4225146345 creator A5030064573 @default.
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- W4225146345 creator A5072022392 @default.
- W4225146345 creator A5073586261 @default.
- W4225146345 creator A5087478205 @default.
- W4225146345 date "2022-04-27" @default.
- W4225146345 modified "2023-10-18" @default.
- W4225146345 title "Alternative Lengthening of Telomeres and Mediated Telomere Synthesis" @default.
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