Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225148347> ?p ?o ?g. }
- W4225148347 endingPage "507" @default.
- W4225148347 startingPage "497" @default.
- W4225148347 abstract "Abstract: An oral route for drug administration is a more suitable route because of its ease of administration, pain avoidance, patient compliance, accommodation of various types of drug molecules, etc. But there are many factors affecting the oral absorption of the drugs. The main factor associated with oral absorption is drug solubility. Many new chemical molecules are poorly soluble in nature and can be included in BCS classes II and IV. For the administration of these drugs through the oral route, it was found that solubility is the rate limiting step. The low solubility of these drugs tends to cause precipitation in the gastrointestinaltract (GIT), affecting their bioavailability. Drug precipitation may be triggered by many factors such as insolubility of the drug in co-solvent, drug-excipient interactions, physiochemical properties of the drug, sudden change in the pH of the environment, incompatibility with the surfactant, etc. Precipitation of a drug may occur in two stages, formation of nucleation and crystal growth. To overcome precipitation, there are many strategies such as the use of polymers, the addition of surfactants, modulating drug loading and solubilizing capacity, change in the pH of the environment, etc. In this review, the causes of precipitation and diverse strategies of precipitation inhibition are critically reviewed." @default.
- W4225148347 created "2022-05-01" @default.
- W4225148347 creator A5033160419 @default.
- W4225148347 creator A5073167564 @default.
- W4225148347 creator A5085259541 @default.
- W4225148347 date "2023-06-01" @default.
- W4225148347 modified "2023-09-30" @default.
- W4225148347 title "Critical Strategies for Drug Precipitation Inhibition: A Review with the Focus on Poorly Soluble Drugs" @default.
- W4225148347 cites W1967387744 @default.
- W4225148347 cites W1978360672 @default.
- W4225148347 cites W1979847090 @default.
- W4225148347 cites W1980495221 @default.
- W4225148347 cites W1981760279 @default.
- W4225148347 cites W1988609515 @default.
- W4225148347 cites W1990663620 @default.
- W4225148347 cites W1995814887 @default.
- W4225148347 cites W1997341902 @default.
- W4225148347 cites W1998154319 @default.
- W4225148347 cites W1998551037 @default.
- W4225148347 cites W1999711931 @default.
- W4225148347 cites W2000004607 @default.
- W4225148347 cites W2002719464 @default.
- W4225148347 cites W2004282507 @default.
- W4225148347 cites W2004895912 @default.
- W4225148347 cites W2011026401 @default.
- W4225148347 cites W2014009819 @default.
- W4225148347 cites W2015297129 @default.
- W4225148347 cites W2018312534 @default.
- W4225148347 cites W2021713550 @default.
- W4225148347 cites W2023169879 @default.
- W4225148347 cites W2024897759 @default.
- W4225148347 cites W2026208618 @default.
- W4225148347 cites W2032353075 @default.
- W4225148347 cites W2034209387 @default.
- W4225148347 cites W2046017608 @default.
- W4225148347 cites W2051224504 @default.
- W4225148347 cites W2054428155 @default.
- W4225148347 cites W2061709421 @default.
- W4225148347 cites W2064572156 @default.
- W4225148347 cites W2066024185 @default.
- W4225148347 cites W2067777829 @default.
- W4225148347 cites W2071372590 @default.
- W4225148347 cites W2072185489 @default.
- W4225148347 cites W2072632039 @default.
- W4225148347 cites W2076269997 @default.
- W4225148347 cites W2078798494 @default.
- W4225148347 cites W2079574505 @default.
- W4225148347 cites W2083704031 @default.
- W4225148347 cites W2086382785 @default.
- W4225148347 cites W2087644924 @default.
- W4225148347 cites W2089926889 @default.
- W4225148347 cites W2092053998 @default.
- W4225148347 cites W2095033482 @default.
- W4225148347 cites W2104805279 @default.
- W4225148347 cites W2115366538 @default.
- W4225148347 cites W2133061356 @default.
- W4225148347 cites W2134419528 @default.
- W4225148347 cites W2135130257 @default.
- W4225148347 cites W2151823004 @default.
- W4225148347 cites W2156829937 @default.
- W4225148347 cites W2157565882 @default.
- W4225148347 cites W2157736127 @default.
- W4225148347 cites W2166609445 @default.
- W4225148347 cites W2312314935 @default.
- W4225148347 cites W2315650590 @default.
- W4225148347 cites W2333000505 @default.
- W4225148347 cites W2335512730 @default.
- W4225148347 cites W2497875504 @default.
- W4225148347 cites W2515297195 @default.
- W4225148347 cites W2521401415 @default.
- W4225148347 cites W2601586195 @default.
- W4225148347 cites W2612534502 @default.
- W4225148347 cites W2764339438 @default.
- W4225148347 cites W2803399459 @default.
- W4225148347 cites W2811345172 @default.
- W4225148347 cites W2897051859 @default.
- W4225148347 cites W2911724414 @default.
- W4225148347 cites W2991590023 @default.
- W4225148347 cites W3016603775 @default.
- W4225148347 cites W3022111635 @default.
- W4225148347 doi "https://doi.org/10.2174/1567201819666220427123101" @default.
- W4225148347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35490319" @default.
- W4225148347 hasPublicationYear "2023" @default.
- W4225148347 type Work @default.
- W4225148347 citedByCount "0" @default.
- W4225148347 crossrefType "journal-article" @default.
- W4225148347 hasAuthorship W4225148347A5033160419 @default.
- W4225148347 hasAuthorship W4225148347A5073167564 @default.
- W4225148347 hasAuthorship W4225148347A5085259541 @default.
- W4225148347 hasConcept C107054158 @default.
- W4225148347 hasConcept C121332964 @default.
- W4225148347 hasConcept C125287762 @default.
- W4225148347 hasConcept C153294291 @default.
- W4225148347 hasConcept C155574463 @default.
- W4225148347 hasConcept C159985019 @default.
- W4225148347 hasConcept C178790620 @default.
- W4225148347 hasConcept C181389837 @default.
- W4225148347 hasConcept C185592680 @default.