Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225151919> ?p ?o ?g. }
- W4225151919 abstract "Melatonin is an important molecule in both animals and plants, regulating circadian rhythms and stress responses. Therefore, the improvement of melatonin accumulation not only strengthens the function of melatonin but also improves stress resistance in crops. Although melatonin biosynthetic enzymes have been identified through reverse genetics previously, an investigation of melatonin level-related genes through forward genetics in plants has yet to be performed. In this study, a genome-wide association study using cassava natural population of 298 genetic resources identified melatonin accumulation 1 (MA1), which regulates the natural variation of melatonin levels in cassava. We found that MA1 encodes type 2C protein phosphatase 1 (PP2C1), which serves as a negative regulator of melatonin levels in cassava. MePP2C1 physically interacts with MeRAV1/2 and MeWRKY20 and dephosphorylates them at serine (S) 35 residue, S34 residue, and S176 residue, respectively, thereby hindering their transcriptional activation on downstream melatonin biosynthetic genes. Notably, MePP2C1 interacts with phytomelatonin receptor MePMTR1 and dephosphorylates it at S11 residue, repressing its binding to melatonin. In summary, this study demonstrates that MePP2C1 as MA1 plays dual roles in negatively regulating both melatonin accumulation and signaling, extending the understanding of the molecular mechanism underlying melatonin accumulation and signaling through forward genetics in plants." @default.
- W4225151919 created "2022-05-01" @default.
- W4225151919 creator A5006845223 @default.
- W4225151919 creator A5009043320 @default.
- W4225151919 creator A5024016351 @default.
- W4225151919 creator A5024162379 @default.
- W4225151919 creator A5034212839 @default.
- W4225151919 creator A5063159500 @default.
- W4225151919 creator A5063519949 @default.
- W4225151919 creator A5067786455 @default.
- W4225151919 creator A5068079517 @default.
- W4225151919 creator A5078916889 @default.
- W4225151919 creator A5081271875 @default.
- W4225151919 creator A5084963625 @default.
- W4225151919 date "2022-05-13" @default.
- W4225151919 modified "2023-10-18" @default.
- W4225151919 title "PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava" @default.
- W4225151919 cites W1520322309 @default.
- W4225151919 cites W1997038372 @default.
- W4225151919 cites W2005458067 @default.
- W4225151919 cites W2038163496 @default.
- W4225151919 cites W2044498079 @default.
- W4225151919 cites W2052821301 @default.
- W4225151919 cites W2066829062 @default.
- W4225151919 cites W2096160166 @default.
- W4225151919 cites W2101463625 @default.
- W4225151919 cites W2110035718 @default.
- W4225151919 cites W2162530578 @default.
- W4225151919 cites W2168612888 @default.
- W4225151919 cites W2289060454 @default.
- W4225151919 cites W2313931749 @default.
- W4225151919 cites W2340858006 @default.
- W4225151919 cites W2344472469 @default.
- W4225151919 cites W2518394958 @default.
- W4225151919 cites W2531442511 @default.
- W4225151919 cites W2550652947 @default.
- W4225151919 cites W2567504706 @default.
- W4225151919 cites W2605612340 @default.
- W4225151919 cites W2730538302 @default.
- W4225151919 cites W2746723602 @default.
- W4225151919 cites W2765657939 @default.
- W4225151919 cites W2769453000 @default.
- W4225151919 cites W2792159457 @default.
- W4225151919 cites W2797088263 @default.
- W4225151919 cites W2799888831 @default.
- W4225151919 cites W2803275252 @default.
- W4225151919 cites W2803714548 @default.
- W4225151919 cites W2804103085 @default.
- W4225151919 cites W2900804561 @default.
- W4225151919 cites W2914464480 @default.
- W4225151919 cites W2915607364 @default.
- W4225151919 cites W2949299396 @default.
- W4225151919 cites W2949550997 @default.
- W4225151919 cites W2952386424 @default.
- W4225151919 cites W2956469826 @default.
- W4225151919 cites W2968189529 @default.
- W4225151919 cites W2969356357 @default.
- W4225151919 cites W3008960338 @default.
- W4225151919 cites W3009849443 @default.
- W4225151919 cites W3012876520 @default.
- W4225151919 cites W3026876696 @default.
- W4225151919 cites W3030345868 @default.
- W4225151919 cites W3033746727 @default.
- W4225151919 cites W3041811562 @default.
- W4225151919 cites W3047880613 @default.
- W4225151919 cites W3093019712 @default.
- W4225151919 cites W3095587678 @default.
- W4225151919 cites W3104834311 @default.
- W4225151919 cites W3126316681 @default.
- W4225151919 cites W3133071733 @default.
- W4225151919 cites W3151211907 @default.
- W4225151919 cites W3213893787 @default.
- W4225151919 cites W3216901609 @default.
- W4225151919 doi "https://doi.org/10.1111/jpi.12804" @default.
- W4225151919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35488179" @default.
- W4225151919 hasPublicationYear "2022" @default.
- W4225151919 type Work @default.
- W4225151919 citedByCount "9" @default.
- W4225151919 countsByYear W42251519192022 @default.
- W4225151919 countsByYear W42251519192023 @default.
- W4225151919 crossrefType "journal-article" @default.
- W4225151919 hasAuthorship W4225151919A5006845223 @default.
- W4225151919 hasAuthorship W4225151919A5009043320 @default.
- W4225151919 hasAuthorship W4225151919A5024016351 @default.
- W4225151919 hasAuthorship W4225151919A5024162379 @default.
- W4225151919 hasAuthorship W4225151919A5034212839 @default.
- W4225151919 hasAuthorship W4225151919A5063159500 @default.
- W4225151919 hasAuthorship W4225151919A5063519949 @default.
- W4225151919 hasAuthorship W4225151919A5067786455 @default.
- W4225151919 hasAuthorship W4225151919A5068079517 @default.
- W4225151919 hasAuthorship W4225151919A5078916889 @default.
- W4225151919 hasAuthorship W4225151919A5081271875 @default.
- W4225151919 hasAuthorship W4225151919A5084963625 @default.
- W4225151919 hasConcept C104317684 @default.
- W4225151919 hasConcept C11960822 @default.
- W4225151919 hasConcept C126322002 @default.
- W4225151919 hasConcept C134018914 @default.
- W4225151919 hasConcept C170493617 @default.
- W4225151919 hasConcept C2776414213 @default.
- W4225151919 hasConcept C2778182776 @default.