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• W4225152023 endingPage "110562" @default.
• W4225152023 startingPage "110562" @default.
• W4225152023 abstract "N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into the illicit drug market. This drug has psychostimulant properties and has been related with several intoxications and even fatalities. However, information about the consequences of its acute and repeated consumption is lacking. Thus, the aim of our study was to investigate the behavioral effects after both acute and repeated NEPD exposure as well as the neurochemical changes. Male OF1 mice were treated with an acute dose (1, 3 or 10 mg/kg, i.p.) or received repeated injections of these doses (twice/day, 5 days) of NEPD. Shortly after drug-exposure or during drug-withdrawal, anxiety-like behavior, aggressiveness, social interaction, depressive-like symptoms, body weight and temperature were assessed. Also, monoamine synthesis enzymes, levels of neurotransmitters and their precursors and main metabolites, as well as ΔFosB, were determined in striatum and prefrontal cortex from post-mortem tissue. Acute administration of NEPD induced anxiolytic effects and reduced social exploration whereas during withdrawal after repeated administration the anxiolytic effect had vanished, and the reduced social exploration was still present and accompanied with increased aggressive behavior. Moreover, NEPD (10 mg/kg) induced slight hyperthermia and reduced weight gain during the repeated administration, whereas increased locomotor activity and lack of depressive symptoms were found during withdrawal. This was accompanied by increased plasma corticosterone and decrease in striatal dopamine. Finally, the long-lasting and robust increase in ΔFosB levels found in striatum after NEPD chronic exposure suggests a high risk of dependence. The increased aggressivity and locomotor activity, together with this potential of inducing dependence justify a warning about the risks of consumption of NEPD if translated to humans." @default.
• W4225152023 created "2022-05-01" @default.
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• W4225152023 date "2022-07-01" @default.
• W4225152023 modified "2023-10-18" @default.
• W4225152023 title "Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice" @default.
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• W4225152023 cites W1606279585 @default.
• W4225152023 cites W176153765 @default.
• W4225152023 cites W1852587300 @default.
• W4225152023 cites W1959245327 @default.
• W4225152023 cites W1966676904 @default.
• W4225152023 cites W1971191340 @default.
• W4225152023 cites W1973287358 @default.
• W4225152023 cites W1982243354 @default.
• W4225152023 cites W1987520942 @default.
• W4225152023 cites W1995588094 @default.
• W4225152023 cites W2004429380 @default.
• W4225152023 cites W2013233086 @default.
• W4225152023 cites W2019908904 @default.
• W4225152023 cites W2025657027 @default.
• W4225152023 cites W2031974507 @default.
• W4225152023 cites W2032674938 @default.
• W4225152023 cites W2037111632 @default.
• W4225152023 cites W2038738168 @default.
• W4225152023 cites W2039244923 @default.
• W4225152023 cites W2043588596 @default.
• W4225152023 cites W2046140045 @default.
• W4225152023 cites W2049988816 @default.
• W4225152023 cites W2058459083 @default.
• W4225152023 cites W2059567546 @default.
• W4225152023 cites W2075168633 @default.
• W4225152023 cites W2075782291 @default.
• W4225152023 cites W2077799006 @default.
• W4225152023 cites W2083714975 @default.
• W4225152023 cites W2084193186 @default.
• W4225152023 cites W2085087502 @default.
• W4225152023 cites W2090205497 @default.
• W4225152023 cites W2096008253 @default.
• W4225152023 cites W2096313008 @default.
• W4225152023 cites W2097645509 @default.
• W4225152023 cites W2141252691 @default.
• W4225152023 cites W2145587240 @default.
• W4225152023 cites W2159447534 @default.
• W4225152023 cites W2194633751 @default.
• W4225152023 cites W2194668596 @default.
• W4225152023 cites W2288777865 @default.
• W4225152023 cites W2327563727 @default.
• W4225152023 cites W2345812239 @default.
• W4225152023 cites W2668896692 @default.
• W4225152023 cites W2736205326 @default.
• W4225152023 cites W2765940959 @default.
• W4225152023 cites W2783275500 @default.
• W4225152023 cites W2783826249 @default.
• W4225152023 cites W2802172273 @default.
• W4225152023 cites W2895277615 @default.
• W4225152023 cites W2895715411 @default.
• W4225152023 cites W2896570148 @default.
• W4225152023 cites W2899913108 @default.
• W4225152023 cites W2900236406 @default.
• W4225152023 cites W2917618396 @default.
• W4225152023 cites W2922969868 @default.
• W4225152023 cites W2942564585 @default.
• W4225152023 cites W2946700363 @default.
• W4225152023 cites W2947628047 @default.
• W4225152023 cites W2981642393 @default.
• W4225152023 cites W3014121938 @default.
• W4225152023 cites W3034871545 @default.
• W4225152023 cites W3044964307 @default.
• W4225152023 cites W3082364121 @default.
• W4225152023 cites W3127645683 @default.
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• W4225152023 cites W3210645845 @default.
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• W4225152023 doi "https://doi.org/10.1016/j.pnpbp.2022.110562" @default.
• W4225152023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35500841" @default.
• W4225152023 hasPublicationYear "2022" @default.
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