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- W4225152507 endingPage "119546" @default.
- W4225152507 startingPage "119546" @default.
- W4225152507 abstract "Catheter-related bloodstream infections (CRBSI) are the major concern of patients undergoing hemodialysis. The current study formulates bifunctional low molecular weight heparin (LMWH) coated nanosilver as an effective anticoagulant and antimicrobial/anti-biofilm agent. Nanosilver formulations were prepared using a microwave-assisted green synthesis approach and stabilized with pharmaceutically approved LMWH such as dalteparin (DL) and enoxaparin (EX) along with unfractionated heparin (HP) as a control. The obtained heparinized (HP/DL/EX) nanosilver was monodisperse, and the size ranged between 15 and 25 nm. DL/EX predominantly stabilized the nanosilver by primarily engaging their negatively charged sulfate groups. The obtained DL/EX coated nanosilver are hemocompatible, showed two times increase in their anticoagulation activity, and are highly potent in inhibiting/eradicating both mono- and polymicrobial biofilms. Henceforth, the observed biocompatible and enhanced bifunctional characteristics of DL/EX coated nanosilver can be used to replace the systemic antibiotics and can be an alternative catheter lock solution to prevent CRBSI in hemodialysis therapy." @default.
- W4225152507 created "2022-05-01" @default.
- W4225152507 creator A5023454945 @default.
- W4225152507 creator A5055084469 @default.
- W4225152507 date "2022-09-01" @default.
- W4225152507 modified "2023-09-30" @default.
- W4225152507 title "Bifunctional Dalteparin/Enoxaparin coated nanosilver formulation to prevent bloodstream infections during hemodialysis" @default.
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- W4225152507 doi "https://doi.org/10.1016/j.carbpol.2022.119546" @default.
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