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- W4225153929 abstract "The present study was aimed to design and optimize brimonidine tartrate (BRT) loaded cationic-charged liposome formulation with enhanced trans-corneal drug permeation, prolonged corneal residence, and sustained drug release for effective ocular delivery.Design of experiment (DoE) based formulation optimization was done by three-factor, three-level Box-Behnken design selecting lipid, cholesterol, and drug content as independent variables and particle size (PS), polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE%), and cumulative % drug release (CDR) as response variables. The optimized formulation consisting of 79.2 mM lipid, 36.2 mM cholesterol, and 15.8 mg/mL drug was prepared by thin film hydration-sonication method using EPCS:DOTAP (1:1) as lipid component and characterized for all desired critical quality attributes (CQAs), drug release kinetics, TEM, DSC, XRD analysis, ex vivo trans-corneal drug permeation, and physical stability studies.The optimized liposome formulation exhibited experimentally observed responses close to predicted values having 150.4 nm (PS), 0.203 (PDI), 30.62 mV (ZP), and 55.17% (EE). The observed CDR (%) was 36.15% at 1 h and 91.13% at 12 h exhibiting sustained drug release profile and followed Higuchi drug release kinetics. The TEM, DSC, and XRD studies revealed spherical, nanosized, small unilamellar vesicles effectively entrapping BRT in liposomes. The ex vivo permeation study across goat cornea recorded apparent permeability (Papp) 1.011 ± 0.07 cm.min-1 and steady-state flux (Jss) 17.63 ± 1.22 µg.cm-2.min-1 showing >2-fold enhanced drug permeation as compared to BRT solution.The developed liposomal formulation possessed all recommended CQAs in optimal range with enhanced trans-corneal drug permeation and remained physically stable in 3 months stability study." @default.
- W4225153929 created "2022-05-01" @default.
- W4225153929 creator A5039951039 @default.
- W4225153929 creator A5085140770 @default.
- W4225153929 date "2021-11-02" @default.
- W4225153929 modified "2023-09-26" @default.
- W4225153929 title "Formulation design and optimization of cationic-charged liposomes of brimonidine tartrate for effective ocular drug delivery by design of experiment (DoE) approach" @default.
- W4225153929 cites W1219162497 @default.
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- W4225153929 cites W1973587651 @default.
- W4225153929 cites W1973990425 @default.
- W4225153929 cites W1974212461 @default.
- W4225153929 cites W1981652223 @default.
- W4225153929 cites W1987972426 @default.
- W4225153929 cites W1988413525 @default.
- W4225153929 cites W1989845428 @default.
- W4225153929 cites W1992253025 @default.
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- W4225153929 cites W2011267269 @default.
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- W4225153929 cites W2023903257 @default.
- W4225153929 cites W2025636925 @default.
- W4225153929 cites W2030968061 @default.
- W4225153929 cites W2033632019 @default.
- W4225153929 cites W2044018172 @default.
- W4225153929 cites W2045296265 @default.
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- W4225153929 cites W2054055267 @default.
- W4225153929 cites W2057939348 @default.
- W4225153929 cites W2058100634 @default.
- W4225153929 cites W2062697134 @default.
- W4225153929 cites W2066947166 @default.
- W4225153929 cites W2068672573 @default.
- W4225153929 cites W2073132059 @default.
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- W4225153929 cites W2081030263 @default.
- W4225153929 cites W2081132468 @default.
- W4225153929 cites W2084872267 @default.
- W4225153929 cites W2097603366 @default.
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- W4225153929 cites W2114018039 @default.
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- W4225153929 cites W3118547704 @default.
- W4225153929 cites W3214890016 @default.
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- W4225153929 doi "https://doi.org/10.1080/03639045.2022.2070198" @default.
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