FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225155361> ?p ?o ?g. }

• W4225155361 endingPage "609" @default.
• W4225155361 startingPage "609" @default.
• W4225155361 abstract "Methicillin-resistant Staphylococcus (MRS) is a leading cause of skin and soft tissue infections in companion animals, with limited treatment options available due to the frequent cross-resistance of MRS to other antibiotics. In this study, we report the prevalence, species distribution, genetic diversity, resistance mechanism and cross-resistance patterns of MRS isolated from companion animal (mostly dog and cat) clinical cases submitted to Iowa State University Veterinary Diagnostic Laboratory (ISU VDL) between 2012 and 2019. The majority of isolates were identified as Staphylococcus pseudintermedius (68.3%; 2379/3482) and coagulase-negative Staphylococcus (CoNS) (24.6%; 857/3482), of which 23.9% and 40.5% were phenotypically resistant to methicillin, respectively. Cross resistance to other β-lactams (and to a lesser extent to non-β-lactams) was common in both methicillin-resistant S. pseudintermedius (MRSP) and CoNS (MRCoNS), especially when oxacillin MIC was ≥4 μg/mL (vs. ≥0.5−<4 μg/mL). The PBP2a protein was detected by agglutination in 94.6% (521/551) MRSP and 64.3% (146/227) MRCoNS. A further analysis of 31 PBP2a-negative MRS isolates (all but one MRCoNS) indicated that 11 were mecA gene-positive while 20 were negative for mecA and other mec genes by PCR. The resistance to last-resort anti-staphylococcal human drugs (e.g., tigecycline, linezolid, vancomycin) among the MRS tested was none to very low. Even though genotyping indicated an overall high level of genetic diversity (87 unique PFGE patterns and 20 MLST types) among a subset of MRSP isolates tested (n = 106), certain genotypes were detected from epidemiologically connected cases at the same or different time points, suggesting persistence and/or nosocomial transmission. These results indicate a relatively high prevalence of MRS from companion animals in the Midwestern US; therefore, it is important to perform routine susceptibility testing of Staphylococcus in veterinary clinical settings for the selection of appropriate antimicrobial therapy." @default.
• W4225155361 created "2022-05-01" @default.
• W4225155361 creator A5017314356 @default.
• W4225155361 creator A5025498781 @default.
• W4225155361 creator A5032561704 @default.
• W4225155361 creator A5055083137 @default.
• W4225155361 creator A5066135028 @default.
• W4225155361 date "2022-04-30" @default.
• W4225155361 modified "2023-09-26" @default.
• W4225155361 title "Prevalence, Mechanism, Genetic Diversity, and Cross-Resistance Patterns of Methicillin-Resistant Staphylococcus Isolated from Companion Animal Clinical Samples Submitted to a Veterinary Diagnostic Laboratory in the Midwestern United States" @default.
• W4225155361 cites W1537791213 @default.
• W4225155361 cites W1588562755 @default.
• W4225155361 cites W1974113734 @default.
• W4225155361 cites W1980427201 @default.
• W4225155361 cites W1984208458 @default.
• W4225155361 cites W1988273869 @default.
• W4225155361 cites W1999315918 @default.
• W4225155361 cites W2021894417 @default.
• W4225155361 cites W2053061199 @default.
• W4225155361 cites W2064636390 @default.
• W4225155361 cites W2076896128 @default.
• W4225155361 cites W2081835782 @default.
• W4225155361 cites W2095542253 @default.
• W4225155361 cites W2098481913 @default.
• W4225155361 cites W2100883347 @default.
• W4225155361 cites W2101926480 @default.
• W4225155361 cites W2102217986 @default.
• W4225155361 cites W2106530803 @default.
• W4225155361 cites W2115544998 @default.
• W4225155361 cites W2120838832 @default.
• W4225155361 cites W2127341421 @default.
• W4225155361 cites W2128701768 @default.
• W4225155361 cites W2130462828 @default.
• W4225155361 cites W2134460424 @default.
• W4225155361 cites W2149352957 @default.
• W4225155361 cites W2169871093 @default.
• W4225155361 cites W2172566893 @default.
• W4225155361 cites W2174362062 @default.
• W4225155361 cites W2174378920 @default.
• W4225155361 cites W2175738866 @default.
• W4225155361 cites W2253655491 @default.
• W4225155361 cites W2291990117 @default.
• W4225155361 cites W2295031408 @default.
• W4225155361 cites W2337642572 @default.
• W4225155361 cites W2382455293 @default.
• W4225155361 cites W2399838540 @default.
• W4225155361 cites W2402718303 @default.
• W4225155361 cites W2462786223 @default.
• W4225155361 cites W2510161974 @default.
• W4225155361 cites W2523003117 @default.
• W4225155361 cites W2533791971 @default.
• W4225155361 cites W2537090390 @default.
• W4225155361 cites W2562400674 @default.
• W4225155361 cites W2571228605 @default.
• W4225155361 cites W2580083742 @default.
• W4225155361 cites W2583044661 @default.
• W4225155361 cites W2592591007 @default.
• W4225155361 cites W2605998708 @default.
• W4225155361 cites W2611861125 @default.
• W4225155361 cites W2614419964 @default.
• W4225155361 cites W2622600745 @default.
• W4225155361 cites W2625133780 @default.
• W4225155361 cites W2761088239 @default.
• W4225155361 cites W2762182227 @default.
• W4225155361 cites W2768709910 @default.
• W4225155361 cites W2770118229 @default.
• W4225155361 cites W2781599883 @default.
• W4225155361 cites W2801070284 @default.
• W4225155361 cites W2802235059 @default.
• W4225155361 cites W2892224462 @default.
• W4225155361 cites W2893038421 @default.
• W4225155361 cites W2905038452 @default.
• W4225155361 cites W2905513411 @default.
• W4225155361 cites W2912348996 @default.
• W4225155361 cites W2922927304 @default.
• W4225155361 cites W2924720709 @default.
• W4225155361 cites W3016914807 @default.
• W4225155361 cites W3020294130 @default.
• W4225155361 cites W3033772524 @default.
• W4225155361 cites W3042395775 @default.
• W4225155361 cites W3123806720 @default.
• W4225155361 cites W3124577960 @default.
• W4225155361 cites W4205412686 @default.
• W4225155361 cites W4211195390 @default.
• W4225155361 cites W4221105643 @default.
• W4225155361 cites W4230079344 @default.
• W4225155361 cites W4236897306 @default.
• W4225155361 cites W91155286 @default.
• W4225155361 doi "https://doi.org/10.3390/antibiotics11050609" @default.
• W4225155361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35625253" @default.
• W4225155361 hasPublicationYear "2022" @default.
• W4225155361 type Work @default.
• W4225155361 citedByCount "4" @default.
• W4225155361 countsByYear W42251553612023 @default.
• W4225155361 crossrefType "journal-article" @default.
• W4225155361 hasAuthorship W4225155361A5017314356 @default.
• W4225155361 hasAuthorship W4225155361A5025498781 @default.
• W4225155361 hasAuthorship W4225155361A5032561704 @default.

• next