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• W4225156915 endingPage "114418" @default.
• W4225156915 startingPage "114418" @default.
• W4225156915 abstract "Four novel bifluorescent Zn(II)-cryptolepine-cyclen complexes, namely [Zn(BQTC)]Cl2 (Zn(BQTC)), [Zn(BQA) (Cur)Cl] (Zn(BQACur)), [Zn (TC)]Cl2 (Zn(TC)), and [Zn (AP) (Cur)Cl] (Zn(APCur)), bearing curcumin (H-Cur), cyclen (TC), 1,10-phenanthrolin-5-amine (AP), and novel cryptolepine-cyclen derivatives (BQTC and BQA) were prepared for cell nucleus- and mitochondria-specific imaging. MTT assay results indicated that Zn(BQTC) and Zn(BQACur) exhibit stronger anticancer activity against cisplatin-resistant A549R lung tumor cells than ZnCl2, Zn(TC), Zn(APCur), H-Cur, TC, AP, BQTC, and BQA. Due to the dual fluorescence characteristic of Zn(BQTC), selective fluorescence imaging of the nucleus and mitochondria of A549R cancer cells was conducted. Further, Zn(BQTC), obtained by the functionalization of Zn(TC) with cryptolepine derivative substituents, efficiently inhibited DNA synthesis, thus resulting in high cytotoxicity (selective for A549R lung tumor cells) accompanied by DNA impairment in nuclear and mitochondrial fractions. Additionally, Zn(BQTC) caused severe damage to the mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), sequentially disrupted mitochondrial and nuclear functions, and promoted the DNA damage-induced apoptotic signaling pathway and adenosine triphosphate depletion (ATP). Thus, Zn(BQTC) can be used as an anticancer drug by targeting mtDNA and nDNA. Most importantly, Zn(BQTC) showed higher efficacy in inhibiting cancer growth (55.9%) in A549R tumor-bearing mice than Zn(TC) (31.2%) and cisplatin, along with a promising in vivo safety profile. These results demonstrate the applicability of the developed novel bifluorescent Zn(II)-cryptolepine-cyclen complexes as promising DNA-targeting anticancer agents for cancer treatment." @default.
• W4225156915 created "2022-05-01" @default.
• W4225156915 creator A5020900553 @default.
• W4225156915 creator A5022184782 @default.
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• W4225156915 creator A5059996188 @default.
• W4225156915 creator A5078183901 @default.
• W4225156915 creator A5081424240 @default.
• W4225156915 date "2022-08-01" @default.
• W4225156915 modified "2023-10-17" @default.
• W4225156915 title "Novel bifluorescent Zn(II)–cryptolepine–cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells" @default.
• W4225156915 cites W1789377903 @default.
• W4225156915 cites W1928594450 @default.
• W4225156915 cites W1942048278 @default.
• W4225156915 cites W1965239527 @default.
• W4225156915 cites W1979395573 @default.
• W4225156915 cites W1982462327 @default.
• W4225156915 cites W1993024229 @default.
• W4225156915 cites W1998129814 @default.
• W4225156915 cites W2004346062 @default.
• W4225156915 cites W2031278133 @default.
• W4225156915 cites W2034124607 @default.
• W4225156915 cites W2038138229 @default.
• W4225156915 cites W2039773621 @default.
• W4225156915 cites W2066695813 @default.
• W4225156915 cites W2067272825 @default.
• W4225156915 cites W2069467005 @default.
• W4225156915 cites W2073707228 @default.
• W4225156915 cites W2079466993 @default.
• W4225156915 cites W2089227323 @default.
• W4225156915 cites W2095013153 @default.
• W4225156915 cites W2105668062 @default.
• W4225156915 cites W2124297768 @default.
• W4225156915 cites W2126078308 @default.
• W4225156915 cites W2156916967 @default.
• W4225156915 cites W2160274141 @default.
• W4225156915 cites W2282780569 @default.
• W4225156915 cites W2322281855 @default.
• W4225156915 cites W2332405824 @default.
• W4225156915 cites W2345985966 @default.
• W4225156915 cites W2514193795 @default.
• W4225156915 cites W2516463727 @default.
• W4225156915 cites W2542021661 @default.
• W4225156915 cites W2601729640 @default.
• W4225156915 cites W2615814714 @default.
• W4225156915 cites W263343890 @default.
• W4225156915 cites W2794060187 @default.
• W4225156915 cites W2809548271 @default.
• W4225156915 cites W2896686027 @default.
• W4225156915 cites W2901667029 @default.
• W4225156915 cites W2903467603 @default.
• W4225156915 cites W2910372584 @default.
• W4225156915 cites W2945621579 @default.
• W4225156915 cites W2949056689 @default.
• W4225156915 cites W2963035169 @default.
• W4225156915 cites W2968078280 @default.
• W4225156915 cites W2972276186 @default.
• W4225156915 cites W2974342225 @default.
• W4225156915 cites W2975208930 @default.
• W4225156915 cites W2978219792 @default.
• W4225156915 cites W2991979532 @default.
• W4225156915 cites W2992524785 @default.
• W4225156915 cites W2996729307 @default.
• W4225156915 cites W2998756496 @default.
• W4225156915 cites W2999756934 @default.
• W4225156915 cites W3002929399 @default.
• W4225156915 cites W3003760952 @default.
• W4225156915 cites W3009874026 @default.
• W4225156915 cites W3010557696 @default.
• W4225156915 cites W3014712534 @default.
• W4225156915 cites W3015352979 @default.
• W4225156915 cites W3024668894 @default.
• W4225156915 cites W3032337534 @default.
• W4225156915 cites W3044490429 @default.
• W4225156915 cites W3047285013 @default.
• W4225156915 cites W3080814328 @default.
• W4225156915 cites W3083432038 @default.
• W4225156915 cites W3084261920 @default.
• W4225156915 cites W3086907093 @default.
• W4225156915 cites W3087739655 @default.
• W4225156915 cites W3093289353 @default.
• W4225156915 cites W3094629477 @default.
• W4225156915 cites W3097317789 @default.
• W4225156915 cites W3100498958 @default.
• W4225156915 cites W3108592360 @default.
• W4225156915 cites W3117391948 @default.
• W4225156915 cites W3121358586 @default.
• W4225156915 cites W3126480028 @default.
• W4225156915 cites W3128620059 @default.
• W4225156915 cites W3138777232 @default.
• W4225156915 cites W3141094363 @default.
• W4225156915 cites W3156585317 @default.
• W4225156915 cites W3165463011 @default.
• W4225156915 cites W3203303613 @default.
• W4225156915 cites W3205934780 @default.
• W4225156915 cites W4200470354 @default.
• W4225156915 cites W4200568029 @default.

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