Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225162208> ?p ?o ?g. }
- W4225162208 endingPage "115059" @default.
- W4225162208 startingPage "115059" @default.
- W4225162208 abstract "Inherited arrhythmias are the leading causes for cardiac arrest and sudden cardiac death (SCD). Other than ion channel mutations, inherited arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome (LQTS), idiopathic ventricular fibrillation (IVF) and arrhythmogenic right ventricular cardiomyopathy (ARVC/D) may also be instigated by genetic mutations of sarcoplasmic reticulum (SR) proteins, including ryanodine receptor type-2 (RyR2), calsequestrin 2, SR Ca2+-ATPase type-2a (SERCA2a) and phospholamban. In cardiomyocytes, Ca2+ is an essential ion in addition to Na+ and K+ ions with vital roles in arrhythmogenesis. SR plays a critical role in the maintenance of Ca2+ homeostasis which can be disrupted by mutations in SR Ca2+ regulatory proteins or abnormal SR-intracellular organelle interaction. Early afterdepolarizations, delayed afterdepolarizations and reentry are three primary mechanisms contributing to arrhythmias elicited by SR Ca2+ dysregulation in cardiomyocytes. In this review, we will aim to summarize normal SR Ca2+ regulation in cardiomyocytes, mechanisms of how Ca2+ triggers arrhythmias and involvements of SR gene mutations in inherited arrhythmias as well as the possible arrhythmogenic effects of these mutations." @default.
- W4225162208 created "2022-05-01" @default.
- W4225162208 creator A5007706452 @default.
- W4225162208 creator A5019199251 @default.
- W4225162208 creator A5037212361 @default.
- W4225162208 date "2022-06-01" @default.
- W4225162208 modified "2023-09-30" @default.
- W4225162208 title "Sarcoplasmic Reticulum Ca2+ Dysregulation in the Pathophysiology of Inherited Arrhythmia: An Update" @default.
- W4225162208 cites W111410485 @default.
- W4225162208 cites W1599277155 @default.
- W4225162208 cites W1967218656 @default.
- W4225162208 cites W1969840664 @default.
- W4225162208 cites W1974082432 @default.
- W4225162208 cites W1983132795 @default.
- W4225162208 cites W1983710068 @default.
- W4225162208 cites W1984612072 @default.
- W4225162208 cites W1987900026 @default.
- W4225162208 cites W1995247809 @default.
- W4225162208 cites W2012928465 @default.
- W4225162208 cites W2021412160 @default.
- W4225162208 cites W2027380922 @default.
- W4225162208 cites W2030926410 @default.
- W4225162208 cites W2033059279 @default.
- W4225162208 cites W2035906435 @default.
- W4225162208 cites W2037397507 @default.
- W4225162208 cites W2037916899 @default.
- W4225162208 cites W2043247522 @default.
- W4225162208 cites W2046336333 @default.
- W4225162208 cites W2046771956 @default.
- W4225162208 cites W2047112668 @default.
- W4225162208 cites W2048886038 @default.
- W4225162208 cites W2050826596 @default.
- W4225162208 cites W2055809007 @default.
- W4225162208 cites W2055928084 @default.
- W4225162208 cites W2059142008 @default.
- W4225162208 cites W2061688246 @default.
- W4225162208 cites W2070534555 @default.
- W4225162208 cites W2080308068 @default.
- W4225162208 cites W2083270578 @default.
- W4225162208 cites W2084344997 @default.
- W4225162208 cites W2093788375 @default.
- W4225162208 cites W2096579721 @default.
- W4225162208 cites W2108745810 @default.
- W4225162208 cites W2110898364 @default.
- W4225162208 cites W2124053445 @default.
- W4225162208 cites W2126824024 @default.
- W4225162208 cites W2129910735 @default.
- W4225162208 cites W2132811048 @default.
- W4225162208 cites W2135227689 @default.
- W4225162208 cites W2138563537 @default.
- W4225162208 cites W2145537234 @default.
- W4225162208 cites W2146464796 @default.
- W4225162208 cites W2146665756 @default.
- W4225162208 cites W2160546144 @default.
- W4225162208 cites W2165970697 @default.
- W4225162208 cites W2171386386 @default.
- W4225162208 cites W2210163512 @default.
- W4225162208 cites W2237493771 @default.
- W4225162208 cites W2321639681 @default.
- W4225162208 cites W2323295443 @default.
- W4225162208 cites W2336596135 @default.
- W4225162208 cites W2407060090 @default.
- W4225162208 cites W2468959616 @default.
- W4225162208 cites W2523333069 @default.
- W4225162208 cites W2531200829 @default.
- W4225162208 cites W2533344724 @default.
- W4225162208 cites W2537498829 @default.
- W4225162208 cites W2546436312 @default.
- W4225162208 cites W2548502736 @default.
- W4225162208 cites W2557105573 @default.
- W4225162208 cites W2579885605 @default.
- W4225162208 cites W2595978963 @default.
- W4225162208 cites W2604251166 @default.
- W4225162208 cites W2612298265 @default.
- W4225162208 cites W2615002257 @default.
- W4225162208 cites W2623904994 @default.
- W4225162208 cites W2736049462 @default.
- W4225162208 cites W2737181235 @default.
- W4225162208 cites W2766982144 @default.
- W4225162208 cites W2767777174 @default.
- W4225162208 cites W2782487444 @default.
- W4225162208 cites W2798173301 @default.
- W4225162208 cites W2801138799 @default.
- W4225162208 cites W2808110707 @default.
- W4225162208 cites W2887947508 @default.
- W4225162208 cites W2899068558 @default.
- W4225162208 cites W2900768062 @default.
- W4225162208 cites W2902376446 @default.
- W4225162208 cites W2904084183 @default.
- W4225162208 cites W2904496030 @default.
- W4225162208 cites W2905328087 @default.
- W4225162208 cites W2905518644 @default.
- W4225162208 cites W2916665298 @default.
- W4225162208 cites W2917617036 @default.
- W4225162208 cites W2922771874 @default.
- W4225162208 cites W2930952653 @default.
- W4225162208 cites W2961516619 @default.
- W4225162208 cites W2963838625 @default.