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• W4225163917 startingPage "4995" @default.
• W4225163917 abstract "Astrocytes, as the most abundant glial cells in the central nervous system, are tightly integrated into neural networks and participate in numerous aspects of brain physiology and pathology. They are the main homeostatic cells in the central nervous system, and the loss of astrocyte physiological functions and/or gain of pro-inflammatory functions, due to their reactivation or cellular senescence, can have profound impacts on the surrounding microenvironment with pathological outcomes. Although the importance of astrocytes is generally recognized, and both senescence and reactive astrogliosis have been extensively reviewed independently, there are only a few comparative overviews of these complex processes. In this review, we summarize the latest data regarding astrocyte reactivation and senescence, and outline similarities and differences between these phenotypes from morphological, functional, and molecular points of view. A special focus has been given to neurodegenerative diseases, where these phenotypic alternations of astrocytes are significantly implicated. We also summarize current perspectives regarding new advances in model systems based on astrocytes as well as data pointing to these glial cells as potential therapeutic targets." @default.
• W4225163917 created "2022-05-01" @default.
• W4225163917 creator A5023796623 @default.
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• W4225163917 creator A5059170068 @default.
• W4225163917 creator A5076430638 @default.
• W4225163917 creator A5081311568 @default.
• W4225163917 date "2022-04-30" @default.
• W4225163917 modified "2023-10-17" @default.
• W4225163917 title "Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies" @default.
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