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- W4225164016 abstract "Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis. Similarly, significant decreases in monocyte/macrophage infiltration, complement levels, and other markers of inflammation in the injured kidney are observed across multiple studies and species. In essence, decreased renal clearance has the surprising and counterintuitive effect of being an effective treatment for AKI. In this Perspective, the author suggests a hypothesis describing why the uremic milieu is kidney protective and proposes a clinical trial of 'permissive azotemia' to improve renal recovery and long-term renal outcomes in critically ill patients with severe AKI." @default.
- W4225164016 created "2022-05-01" @default.
- W4225164016 creator A5089235509 @default.
- W4225164016 date "2022-04-28" @default.
- W4225164016 modified "2023-09-26" @default.
- W4225164016 title "Permissive azotemia during acute kidney injury enables more rapid renal recovery and less renal fibrosis: a hypothesis and clinical development plan" @default.
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- W4225164016 doi "https://doi.org/10.1186/s13054-022-03988-0" @default.
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