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- W4225165443 abstract "Astrocytes not only provide for the transfer of nutrients between blood vessels and neurons, but also take part in signaling through nerve tissue and regulate formation, pruning, and plasticity of synapses. Analysis of the impact of the astrocytic domain organization on the local and collective dynamics of neurons is needed for both the fundamental understanding of the mechanisms underlying cognition and for the creation of new methods of neurodegenerative pathology treatment targeted at non-neuronal cells without direct effects on the neural network. Based on the available experimental data, we propose a model study of the role of astrocytic calcium signaling in the regulation of synaptic transmission between neurons in order to elucidate the role played by astrocyte calcium signaling in signaling pathways regulating neural activity. The proposed model is based on the following assumptions: (i) localized release of gliotransmitters depends on the spatiotemporal patterns of calcium activity and is determined by cell morphology and topology of the entire network; (ii) the release of gliotransmitters can lead to spatial segregation of the nervous tissue into regions in which different conditions are maintained, favoring for increased or decreased synaptic efficacy." @default.
- W4225165443 created "2022-05-01" @default.
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- W4225165443 date "2022-04-29" @default.
- W4225165443 modified "2023-09-29" @default.
- W4225165443 title "Gliotransmitter-based modulation of presynaptic efficacy provides a feedback between neuronal activity and astrocytic transients" @default.
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- W4225165443 doi "https://doi.org/10.1117/12.2626012" @default.
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