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• W4225247629 endingPage "100039" @default.
• W4225247629 startingPage "100039" @default.
• W4225247629 abstract "Cognitive impairment, particularly deficits in executive function (EF) is common in Parkinson's disease (PD) and may lead to dementia. There are currently no effective treatments for cognitive impairment. Work from our lab and others has shown that physical exercise may improve motor performance in PD but its role in cognitive function remains poorly eludicated. In this study in a rodent model of PD, we sought to examine whether exercise improves cognitive processing and flexibility, important features of EF. Rats received 6-hydroxydopamine lesions of the bilateral striatum (caudate-putamen, CPu), specifically the dorsomedial CPu, a brain region central to EF. Rats were exercised on motorized running wheels or horizontal treadmills for 6–12 weeks. EF-related behaviors including attention and processing, as well as flexibility (inhibition) were evaluated using either an operant 3-choice serial reaction time task (3-CSRT) with rule reversal (3-CSRT-R), or a T-maze task with reversal. Changes in striatal transcript expression of dopamine receptors (Drd1-4) and synaptic proteins (Synaptophysin, PSD-95) were separately examined following 4 weeks of exercise in a subset of rats. Exercise/Lesion rats showed a modest, yet significant improvement in processing-related response accuracy in the 3-CSRT-R and T-maze, as well as a significant improvement in cognitive flexibility as assessed by inhibitory aptitude in the 3-CSRT-R. By four weeks, exercise also elicited increased expression of Drd1, Drd3, Drd4, synaptophysin, and PSD-95 in the dorsomedial and dorsolateral CPu. Our results underscore the observation that exercise, in addition to improving motor function may benefit cognitive performance, specifically EF, and that early changes (by 4 weeks) in CPu dopamine modulation and synaptic connectivity may underlie these benefits." @default.
• W4225247629 created "2022-05-04" @default.
• W4225247629 creator A5004288147 @default.
• W4225247629 creator A5022450091 @default.
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• W4225247629 creator A5043188472 @default.
• W4225247629 creator A5049706279 @default.
• W4225247629 creator A5068363442 @default.
• W4225247629 creator A5072298186 @default.
• W4225247629 date "2022-01-01" @default.
• W4225247629 modified "2023-10-14" @default.
• W4225247629 title "A mind in motion: Exercise improves cognitive flexibility, impulsivity and alters dopamine receptor gene expression in a Parkinsonian rat model" @default.
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• W4225247629 doi "https://doi.org/10.1016/j.crneur.2022.100039" @default.
• W4225247629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36518341" @default.
• W4225247629 hasPublicationYear "2022" @default.

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