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• W4225253181 startingPage "167610" @default.
• W4225253181 abstract "Drug research and development is a multidisciplinary field with its own successes. Yet, given the complexity of the process, it also faces challenges over the long development stages and even includes those that develop once a drug is marketed, i.e. drug toxicity and drug resistance. Better success can be achieved via well designed criteria in the early drug development stages. Here, we introduce the concepts of allostery and missense mutations, and argue that incorporation of these two intermittently linked biological phenomena into the early computational drug discovery stages would help to reduce the attrition risk in later stages of the process. We discuss the individual or in concert mechanisms of actions of mutations in allostery. Design of allosteric drugs is challenging compared to orthosteric drugs, yet they have been gaining popularity in recent years as alternative systems for the therapeutic regulation of proteins with an action-at-a-distance mode and non-invasive mechanisms. We propose an easy-to-apply computational allosteric drug discovery protocol which considers the mutation effect, and detail it with three case studies focusing on (1) analysis of effect of an allosteric mutation related to isoniazid drug resistance in tuberculosis; (2) identification of a cryptic pocket in the presence of an allosteric mutation of falcipain-2 as a malarial drug target; and (3) deciphering the effects of SARS-CoV-2 evolutionary mutations on a potential allosteric modulator with changes to allosteric communication paths." @default.
• W4225253181 created "2022-05-04" @default.
• W4225253181 creator A5004870074 @default.
• W4225253181 creator A5013605617 @default.
• W4225253181 creator A5055672152 @default.
• W4225253181 date "2022-09-01" @default.
• W4225253181 modified "2023-10-18" @default.
• W4225253181 title "Allostery and Missense Mutations as Intermittently Linked Promising Aspects of Modern Computational Drug Discovery" @default.
• W4225253181 cites W1005964084 @default.
• W4225253181 cites W1500036797 @default.
• W4225253181 cites W1519298624 @default.
• W4225253181 cites W167138835 @default.
• W4225253181 cites W1757990252 @default.
• W4225253181 cites W1771087982 @default.
• W4225253181 cites W195064984 @default.
• W4225253181 cites W1964439982 @default.
• W4225253181 cites W1976892175 @default.
• W4225253181 cites W1979110436 @default.
• W4225253181 cites W1992595411 @default.
• W4225253181 cites W1995254028 @default.
• W4225253181 cites W1998093640 @default.
• W4225253181 cites W2003412353 @default.
• W4225253181 cites W200828812 @default.
• W4225253181 cites W2014252415 @default.
• W4225253181 cites W2024111498 @default.
• W4225253181 cites W2034145974 @default.
• W4225253181 cites W2035627524 @default.
• W4225253181 cites W2041205020 @default.
• W4225253181 cites W2043757580 @default.
• W4225253181 cites W2049682677 @default.
• W4225253181 cites W2061090993 @default.
• W4225253181 cites W2063237193 @default.
• W4225253181 cites W2066327580 @default.
• W4225253181 cites W2072345776 @default.
• W4225253181 cites W2075425833 @default.
• W4225253181 cites W2078996434 @default.
• W4225253181 cites W2083147938 @default.
• W4225253181 cites W2083328485 @default.
• W4225253181 cites W2091060891 @default.
• W4225253181 cites W2091583677 @default.
• W4225253181 cites W2096541451 @default.
• W4225253181 cites W2106777560 @default.
• W4225253181 cites W2118234018 @default.
• W4225253181 cites W2130218870 @default.
• W4225253181 cites W2134742468 @default.
• W4225253181 cites W2155097824 @default.
• W4225253181 cites W2159088440 @default.
• W4225253181 cites W2168655844 @default.
• W4225253181 cites W2168798454 @default.
• W4225253181 cites W2170146596 @default.
• W4225253181 cites W2175309784 @default.
• W4225253181 cites W2176516200 @default.
• W4225253181 cites W2177317049 @default.
• W4225253181 cites W2179137438 @default.
• W4225253181 cites W2198907191 @default.
• W4225253181 cites W2327883350 @default.
• W4225253181 cites W2418388116 @default.
• W4225253181 cites W2486258756 @default.
• W4225253181 cites W2528806650 @default.
• W4225253181 cites W2530847795 @default.
• W4225253181 cites W2552346983 @default.
• W4225253181 cites W2590193371 @default.
• W4225253181 cites W2596093293 @default.
• W4225253181 cites W2596679549 @default.
• W4225253181 cites W2597836507 @default.
• W4225253181 cites W2603725361 @default.
• W4225253181 cites W2605311545 @default.
• W4225253181 cites W2605343262 @default.
• W4225253181 cites W2619817401 @default.
• W4225253181 cites W2674944410 @default.
• W4225253181 cites W2729103366 @default.
• W4225253181 cites W2736750446 @default.
• W4225253181 cites W2767891136 @default.
• W4225253181 cites W2769756069 @default.
• W4225253181 cites W2785797662 @default.
• W4225253181 cites W2789866723 @default.
• W4225253181 cites W2790505160 @default.
• W4225253181 cites W2800816519 @default.
• W4225253181 cites W2804369996 @default.
• W4225253181 cites W2810768392 @default.
• W4225253181 cites W2883112336 @default.
• W4225253181 cites W2885134480 @default.
• W4225253181 cites W2896403345 @default.
• W4225253181 cites W2898529048 @default.
• W4225253181 cites W2899070097 @default.
• W4225253181 cites W2904616839 @default.
• W4225253181 cites W2907658565 @default.
• W4225253181 cites W2907978451 @default.
• W4225253181 cites W2911329269 @default.
• W4225253181 cites W2911398658 @default.
• W4225253181 cites W2920104535 @default.
• W4225253181 cites W2924293762 @default.
• W4225253181 cites W2944542290 @default.
• W4225253181 cites W2945027804 @default.
• W4225253181 cites W2950700372 @default.
• W4225253181 cites W2962398326 @default.
• W4225253181 cites W2973039076 @default.
• W4225253181 cites W2979054698 @default.

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