Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225255854> ?p ?o ?g. }
- W4225255854 endingPage "5005" @default.
- W4225255854 startingPage "5005" @default.
- W4225255854 abstract "Named as the guardian of the genome, p53 is a tumor suppressor that regulates cell function, often through many different mechanisms such as DNA repair, apoptosis, cell cycle arrest, senescence, metabolism, and autophagy. One of the genes that p53 activates is MDM2, which forms a negative feedback loop since MDM2 induces the degradation of p53. When p53 activity is inhibited, damaged cells do not undergo cell cycle arrest or apoptosis. As 50% of human cancers inactivate p53 by mutation, current research focuses on reactivating p53 by developing drugs that target the p53-MDM2 interaction, which includes the binding of MDM2 and phosphorylation of p53. The objective of this article is to provide a short list and description of p53-MDM2 antagonists that may be excellent candidates for inducing cancer cell death. Relevant articles were searched for and identified using online databases such as PubMed and ScienceDirect. Increasing p53 levels, by targeting the p53-MDM2 interaction, can help p53 play its role as a tumor suppressor and induce cancer cell death. Researchers have identified different compounds that can act as inhibitors, either by directly binding to MDM2 or by modifying p53 with phosphorylation. The results associated with the drugs demonstrate the importance of targeting such interactions to inhibit cancer cell growth, which indicates that the use of the compounds may improve cancer therapeutics." @default.
- W4225255854 created "2022-05-04" @default.
- W4225255854 creator A5001311093 @default.
- W4225255854 creator A5049564572 @default.
- W4225255854 creator A5051568194 @default.
- W4225255854 date "2022-04-30" @default.
- W4225255854 modified "2023-10-01" @default.
- W4225255854 title "Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death" @default.
- W4225255854 cites W1553367038 @default.
- W4225255854 cites W1602704690 @default.
- W4225255854 cites W16338948 @default.
- W4225255854 cites W1847864430 @default.
- W4225255854 cites W1864563621 @default.
- W4225255854 cites W1965527805 @default.
- W4225255854 cites W1965953555 @default.
- W4225255854 cites W1966841369 @default.
- W4225255854 cites W1968220278 @default.
- W4225255854 cites W1970993216 @default.
- W4225255854 cites W1972166544 @default.
- W4225255854 cites W1972912365 @default.
- W4225255854 cites W1975222501 @default.
- W4225255854 cites W1978518304 @default.
- W4225255854 cites W1983197606 @default.
- W4225255854 cites W1985567682 @default.
- W4225255854 cites W1986068161 @default.
- W4225255854 cites W1987517037 @default.
- W4225255854 cites W1990532502 @default.
- W4225255854 cites W1991167758 @default.
- W4225255854 cites W1991510903 @default.
- W4225255854 cites W1991651255 @default.
- W4225255854 cites W1992190005 @default.
- W4225255854 cites W1993263392 @default.
- W4225255854 cites W1998577031 @default.
- W4225255854 cites W2002466777 @default.
- W4225255854 cites W2008935687 @default.
- W4225255854 cites W2013108773 @default.
- W4225255854 cites W2015700848 @default.
- W4225255854 cites W2017673293 @default.
- W4225255854 cites W2018614905 @default.
- W4225255854 cites W2020808779 @default.
- W4225255854 cites W2020963751 @default.
- W4225255854 cites W2023486531 @default.
- W4225255854 cites W2026523375 @default.
- W4225255854 cites W2028459159 @default.
- W4225255854 cites W2028572776 @default.
- W4225255854 cites W2030608968 @default.
- W4225255854 cites W2030738890 @default.
- W4225255854 cites W2035177083 @default.
- W4225255854 cites W2044387885 @default.
- W4225255854 cites W2046711070 @default.
- W4225255854 cites W2047242201 @default.
- W4225255854 cites W2049436772 @default.
- W4225255854 cites W2053012209 @default.
- W4225255854 cites W2053065962 @default.
- W4225255854 cites W2055551025 @default.
- W4225255854 cites W2056441912 @default.
- W4225255854 cites W2057347757 @default.
- W4225255854 cites W2058218706 @default.
- W4225255854 cites W2061724992 @default.
- W4225255854 cites W2063669247 @default.
- W4225255854 cites W2064372785 @default.
- W4225255854 cites W2064811320 @default.
- W4225255854 cites W2067670322 @default.
- W4225255854 cites W2071555702 @default.
- W4225255854 cites W2073315283 @default.
- W4225255854 cites W2074545297 @default.
- W4225255854 cites W2074798239 @default.
- W4225255854 cites W2076307754 @default.
- W4225255854 cites W2077685869 @default.
- W4225255854 cites W2078314973 @default.
- W4225255854 cites W2082541302 @default.
- W4225255854 cites W2088172108 @default.
- W4225255854 cites W2090240238 @default.
- W4225255854 cites W2090408878 @default.
- W4225255854 cites W2090780313 @default.
- W4225255854 cites W2092722802 @default.
- W4225255854 cites W2093168199 @default.
- W4225255854 cites W2094607113 @default.
- W4225255854 cites W2094916879 @default.
- W4225255854 cites W2096039018 @default.
- W4225255854 cites W2096281488 @default.
- W4225255854 cites W2097616194 @default.
- W4225255854 cites W2097933346 @default.
- W4225255854 cites W2099459640 @default.
- W4225255854 cites W2100448419 @default.
- W4225255854 cites W2103612071 @default.
- W4225255854 cites W2106006192 @default.
- W4225255854 cites W2107418471 @default.
- W4225255854 cites W2107516157 @default.
- W4225255854 cites W2111420633 @default.
- W4225255854 cites W2113370608 @default.
- W4225255854 cites W2114980992 @default.
- W4225255854 cites W2115858839 @default.
- W4225255854 cites W2120709000 @default.
- W4225255854 cites W2120921507 @default.
- W4225255854 cites W2131833681 @default.
- W4225255854 cites W2136714130 @default.
- W4225255854 cites W2137391598 @default.