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- W4225258001 abstract "The increasing resistance of bacteria to existing antibiotics constitutes a major public health threat globally. Most current antibiotic treatments are hindered by poor delivery to the infection site, leading to undesired off-target effects and drug resistance development and spread. Here, we describe micro- and nanomotors that effectively and autonomously deliver antibiotic payloads to the target area. The active motion and antimicrobial activity of the silica-based robots are driven by catalysis of the enzyme urease and antimicrobial peptides, respectively. These antimicrobial motors show micromolar bactericidal activity in vitro against different Gram-positive and Gram-negative pathogenic bacterial strains and act by rapidly depolarizing their membrane. Finally, they demonstrated autonomous anti-infective efficacy in vivo in a clinically relevant abscess infection mouse model. In summary, our motors combine navigation, catalytic conversion, and bactericidal capacity to deliver antimicrobial payloads to specific infection sites. This technology represents a much-needed tool to direct therapeutics to their target to help combat drug-resistant infections." @default.
- W4225258001 created "2022-05-04" @default.
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- W4225258001 date "2022-04-29" @default.
- W4225258001 modified "2023-10-14" @default.
- W4225258001 title "Autonomous Treatment of Bacterial Infections <i>in Vivo</i> Using Antimicrobial Micro- and Nanomotors" @default.
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- W4225258001 doi "https://doi.org/10.1021/acsnano.1c11013" @default.
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