FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225258980> ?p ?o ?g. }

• W4225258980 abstract "Abstract Colorectal cancer (CRC) is among the most widely spread cancers globally. Aberrant alternative polyadenylation (APA) plays a role in cancer onset and its progression. Consequently, this study focused on highlighting the role of APA events and signals in the prognosis of patients with CRC. The APA events, RNA sequencing (RNA-seq), somatic mutations, copy number variants (CNVs), and clinical information of the CRC cohort were obtained from The Cancer Genome Atlas (TCGA) database and UCSC (University of California-Santa Cruz) Xena database. The whole set was sorted into two sets: a training set and a test set in a ratio of 7:3. 197 prognosis-related APA events were collected by performing univariate Cox regression signature in patients with CRC. Subsequently, a signature for APA events was established by least absolute shrinkage and selection operator (LASSO) and multivariate Cox analysis. The risk scores were measured for individual patients on the basis of the signature and patients were sorted into two groups; the high-risk group and the low-risk group as per their median risk scores. Kaplan–Meier curves, principal component analysis (PCA), and time-dependent receiver operator characteristic (ROC) curves revealed that the signature was able to predict patient prognosis effectively and further validation was provided in the test set and the whole set. The high-risk and low-risk groups displayed various distributions of mutations and CNVs. Tumor mutation burden (TMB) alone and in combination with the signature predicted the prognosis of CRC patients, but the gene frequencies of TMBs and CNVs did not change in the low- and high-risk groups. Moreover, immunotherapy and chemotherapy treatments showed different responses to PD-1 inhibitors and multiple chemotherapeutic agents in the low and high-risk groups based on the tumor immune dysfunction and exclusion (TIDE) and genomics of drugs sensitivity in cancer (GDSC) databases. This study may help in understanding the potential roles of APA in CRC, and the signature for prognosis-related APA events can work as a potential predictor for survival and treatment in patients with CRC." @default.
• W4225258980 created "2022-05-04" @default.
• W4225258980 creator A5028285167 @default.
• W4225258980 creator A5034029120 @default.
• W4225258980 creator A5044544424 @default.
• W4225258980 date "2022-04-29" @default.
• W4225258980 modified "2023-09-27" @default.
• W4225258980 title "Alternative polyadenylation associated with prognosis and therapy in colorectal cancer" @default.
• W4225258980 cites W1966107523 @default.
• W4225258980 cites W1973916899 @default.
• W4225258980 cites W1985267020 @default.
• W4225258980 cites W2000666866 @default.
• W4225258980 cites W2022031287 @default.
• W4225258980 cites W2036065307 @default.
• W4225258980 cites W2037766756 @default.
• W4225258980 cites W2074114726 @default.
• W4225258980 cites W2078223002 @default.
• W4225258980 cites W2079645368 @default.
• W4225258980 cites W2086803449 @default.
• W4225258980 cites W2093295511 @default.
• W4225258980 cites W2103074569 @default.
• W4225258980 cites W2108264419 @default.
• W4225258980 cites W2118031210 @default.
• W4225258980 cites W2118834857 @default.
• W4225258980 cites W2130410032 @default.
• W4225258980 cites W2130430382 @default.
• W4225258980 cites W2142578085 @default.
• W4225258980 cites W2151866777 @default.
• W4225258980 cites W2151971476 @default.
• W4225258980 cites W2157852151 @default.
• W4225258980 cites W2159675211 @default.
• W4225258980 cites W2159707944 @default.
• W4225258980 cites W2166663163 @default.
• W4225258980 cites W2285223748 @default.
• W4225258980 cites W2496114304 @default.
• W4225258980 cites W2591493010 @default.
• W4225258980 cites W2739592885 @default.
• W4225258980 cites W2749553776 @default.
• W4225258980 cites W2754362077 @default.
• W4225258980 cites W2765241807 @default.
• W4225258980 cites W2776687758 @default.
• W4225258980 cites W2780166051 @default.
• W4225258980 cites W2785671534 @default.
• W4225258980 cites W2786594082 @default.
• W4225258980 cites W2810032171 @default.
• W4225258980 cites W2886498337 @default.
• W4225258980 cites W2888278605 @default.
• W4225258980 cites W2896872272 @default.
• W4225258980 cites W2897815318 @default.
• W4225258980 cites W2902185751 @default.
• W4225258980 cites W2928665623 @default.
• W4225258980 cites W2944348386 @default.
• W4225258980 cites W2981413017 @default.
• W4225258980 cites W3005014202 @default.
• W4225258980 cites W3008779410 @default.
• W4225258980 cites W3014648232 @default.
• W4225258980 cites W3021707236 @default.
• W4225258980 cites W3082172371 @default.
• W4225258980 cites W3095012544 @default.
• W4225258980 cites W3128646645 @default.
• W4225258980 cites W3137105474 @default.
• W4225258980 cites W3169635495 @default.
• W4225258980 cites W3186477348 @default.
• W4225258980 cites W3190072870 @default.
• W4225258980 cites W3191629161 @default.
• W4225258980 cites W4211199921 @default.
• W4225258980 cites W4232897693 @default.
• W4225258980 cites W3159165932 @default.
• W4225258980 doi "https://doi.org/10.1038/s41598-022-11089-9" @default.
• W4225258980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35487956" @default.
• W4225258980 hasPublicationYear "2022" @default.
• W4225258980 type Work @default.
• W4225258980 citedByCount "0" @default.
• W4225258980 crossrefType "journal-article" @default.
• W4225258980 hasAuthorship W4225258980A5028285167 @default.
• W4225258980 hasAuthorship W4225258980A5034029120 @default.
• W4225258980 hasAuthorship W4225258980A5044544424 @default.
• W4225258980 hasBestOaLocation W42252589801 @default.
• W4225258980 hasConcept C121608353 @default.
• W4225258980 hasConcept C126322002 @default.
• W4225258980 hasConcept C143998085 @default.
• W4225258980 hasConcept C50382708 @default.
• W4225258980 hasConcept C526805850 @default.
• W4225258980 hasConcept C58471807 @default.
• W4225258980 hasConcept C60644358 @default.
• W4225258980 hasConcept C70721500 @default.
• W4225258980 hasConcept C71924100 @default.
• W4225258980 hasConcept C86803240 @default.
• W4225258980 hasConceptScore W4225258980C121608353 @default.
• W4225258980 hasConceptScore W4225258980C126322002 @default.
• W4225258980 hasConceptScore W4225258980C143998085 @default.
• W4225258980 hasConceptScore W4225258980C50382708 @default.
• W4225258980 hasConceptScore W4225258980C526805850 @default.
• W4225258980 hasConceptScore W4225258980C58471807 @default.
• W4225258980 hasConceptScore W4225258980C60644358 @default.
• W4225258980 hasConceptScore W4225258980C70721500 @default.
• W4225258980 hasConceptScore W4225258980C71924100 @default.
• W4225258980 hasConceptScore W4225258980C86803240 @default.
• W4225258980 hasIssue "1" @default.
• W4225258980 hasLocation W42252589801 @default.

• next