FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225265726> ?p ?o ?g. }

• W4225265726 abstract "Autism spectrum disorder is a neurodevelopmental disorder, affecting 1-2% of children. Studies have revealed genetic and cellular abnormalities in the brains of affected individuals, leading to both regional and distal cell communication deficits.Recent application of single-cell technologies, especially single-cell transcriptomics, has significantly expanded our understanding of brain cell heterogeneity and further demonstrated that multiple cell types and brain layers or regions are perturbed in autism. The underlying high-dimensional single-cell data provides opportunities for multilevel computational analysis that collectively can better deconvolute the molecular and cellular events altered in autism. Here, we apply advanced computation and pattern recognition approaches on single-cell RNA-seq data to infer and compare inter-cell-type signaling communications in autism brains and controls.Our results indicate that at a global level, there are cell-cell communication differences in autism in comparison with controls, largely involving neurons as both signaling senders and receivers, but glia also contribute to the communication disruption. Although the magnitude of changes is moderate, we find that excitatory and inhibitor neurons are involved in multiple intercellular signaling that exhibits increased strengths in autism, such as NRXN and CNTN signaling. Not all genes in the intercellular signaling pathways show differential expression, but genes in the affected pathways are enriched for axon guidance, synapse organization, neuron migration, and other critical cellular functions. Furthermore, those genes are highly connected to and enriched for genes previously associated with autism risks.Overall, our proof-of-principle computational study using single-cell data uncovers key intercellular signaling pathways that are potentially disrupted in the autism brains, suggesting that more studies examining cross-cell type effects can be valuable for understanding autism pathogenesis." @default.
• W4225265726 created "2022-05-04" @default.
• W4225265726 creator A5018723084 @default.
• W4225265726 creator A5048727416 @default.
• W4225265726 creator A5053246999 @default.
• W4225265726 date "2022-05-02" @default.
• W4225265726 modified "2023-10-17" @default.
• W4225265726 title "Characterization of cell-cell communication in autistic brains with single-cell transcriptomes" @default.
• W4225265726 cites W1546528060 @default.
• W4225265726 cites W1770497983 @default.
• W4225265726 cites W1963978693 @default.
• W4225265726 cites W1970741708 @default.
• W4225265726 cites W1986561232 @default.
• W4225265726 cites W1993671911 @default.
• W4225265726 cites W1997305347 @default.
• W4225265726 cites W2003668169 @default.
• W4225265726 cites W2003982930 @default.
• W4225265726 cites W2004081462 @default.
• W4225265726 cites W2006615195 @default.
• W4225265726 cites W2024744542 @default.
• W4225265726 cites W2035618305 @default.
• W4225265726 cites W2036208196 @default.
• W4225265726 cites W2043345702 @default.
• W4225265726 cites W2045261759 @default.
• W4225265726 cites W2061772901 @default.
• W4225265726 cites W2063786220 @default.
• W4225265726 cites W2069961692 @default.
• W4225265726 cites W2071837000 @default.
• W4225265726 cites W2080580645 @default.
• W4225265726 cites W2089927164 @default.
• W4225265726 cites W2091994270 @default.
• W4225265726 cites W2092029099 @default.
• W4225265726 cites W2094993131 @default.
• W4225265726 cites W2096173332 @default.
• W4225265726 cites W2096679749 @default.
• W4225265726 cites W2100382861 @default.
• W4225265726 cites W2102350231 @default.
• W4225265726 cites W2103702217 @default.
• W4225265726 cites W2106870542 @default.
• W4225265726 cites W2110374888 @default.
• W4225265726 cites W2111391133 @default.
• W4225265726 cites W2123106337 @default.
• W4225265726 cites W2123372818 @default.
• W4225265726 cites W2127753140 @default.
• W4225265726 cites W2130410032 @default.
• W4225265726 cites W2142680666 @default.
• W4225265726 cites W2145464933 @default.
• W4225265726 cites W2150092716 @default.
• W4225265726 cites W2161761595 @default.
• W4225265726 cites W2169589032 @default.
• W4225265726 cites W2170703764 @default.
• W4225265726 cites W2173612877 @default.
• W4225265726 cites W2292730259 @default.
• W4225265726 cites W2298842603 @default.
• W4225265726 cites W2344695725 @default.
• W4225265726 cites W2549663078 @default.
• W4225265726 cites W2581526753 @default.
• W4225265726 cites W2593370030 @default.
• W4225265726 cites W2602999381 @default.
• W4225265726 cites W2605927575 @default.
• W4225265726 cites W2735817588 @default.
• W4225265726 cites W2766944607 @default.
• W4225265726 cites W2768632708 @default.
• W4225265726 cites W2791363941 @default.
• W4225265726 cites W2888367362 @default.
• W4225265726 cites W2890839967 @default.
• W4225265726 cites W2896133138 @default.
• W4225265726 cites W2896631355 @default.
• W4225265726 cites W2897300390 @default.
• W4225265726 cites W2899911873 @default.
• W4225265726 cites W2904647285 @default.
• W4225265726 cites W2904763455 @default.
• W4225265726 cites W2911564193 @default.
• W4225265726 cites W2914250330 @default.
• W4225265726 cites W2914482125 @default.
• W4225265726 cites W2914906500 @default.
• W4225265726 cites W2946016273 @default.
• W4225265726 cites W2948979641 @default.
• W4225265726 cites W2950938640 @default.
• W4225265726 cites W2952423217 @default.
• W4225265726 cites W2955503846 @default.
• W4225265726 cites W2992151131 @default.
• W4225265726 cites W3003776320 @default.
• W4225265726 cites W3007935255 @default.
• W4225265726 cites W3027179734 @default.
• W4225265726 cites W3044030235 @default.
• W4225265726 cites W3044594590 @default.
• W4225265726 cites W3084557452 @default.
• W4225265726 cites W3092290783 @default.
• W4225265726 cites W3092318937 @default.
• W4225265726 cites W3099810371 @default.
• W4225265726 cites W3126257077 @default.
• W4225265726 cites W3126958162 @default.
• W4225265726 cites W3132661792 @default.
• W4225265726 cites W3156280969 @default.
• W4225265726 cites W3156358070 @default.
• W4225265726 cites W3163835391 @default.
• W4225265726 cites W3165051998 @default.
• W4225265726 cites W3171692328 @default.
• W4225265726 cites W3176937353 @default.

• next