FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225270108> ?p ?o ?g. }

• W4225270108 abstract "Abstract Background For the most part, genome-wide association studies (GWAS) have only partially explained the heritability of complex diseases. One of their limitations is to assume independent contributions of individual variants to the phenotype. Many tools have therefore been developed to investigate the interactions between distant loci, or epistasis. Among them, the recently proposed EpiGWAS models the interactions between a target variant and the rest of the genome. However, applying this approach to studying interactions along all genes of a disease map is not straightforward. Here, we propose a pipeline to that effect, which we illustrate by investigating a multiple sclerosis GWAS dataset from the Wellcome Trust Case Control Consortium 2 through 19 disease maps from the MetaCore pathway database. Results For each disease map, we build an epistatic network by connecting the genes that are deemed to interact. These networks tend to be connected, complementary to the disease maps and contain hubs. In addition, we report 4 epistatic gene pairs involving missense variants, and 25 gene pairs with a deleterious epistatic effect mediated by eQTLs. Among these, we highlight the interaction of GLI-1 and SUFU, and of IP10 and NF- $$kappa$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mi>κ</mml:mi> </mml:math> B, as they both match known biological interactions. The latter pair is particularly promising for therapeutic development, as both genes have known inhibitors. Conclusions Our study showcases the ability of EpiGWAS to uncover biologically interpretable epistatic interactions that are potentially actionable for the development of combination therapy." @default.
• W4225270108 created "2022-05-04" @default.
• W4225270108 creator A5042823264 @default.
• W4225270108 creator A5054755903 @default.
• W4225270108 creator A5056066550 @default.
• W4225270108 creator A5075011348 @default.
• W4225270108 date "2022-04-30" @default.
• W4225270108 modified "2023-10-02" @default.
• W4225270108 title "A systematic analysis of gene–gene interaction in multiple sclerosis" @default.
• W4225270108 cites W1975499742 @default.
• W4225270108 cites W2007669896 @default.
• W4225270108 cites W2010220933 @default.
• W4225270108 cites W2030628077 @default.
• W4225270108 cites W2040547343 @default.
• W4225270108 cites W2050311264 @default.
• W4225270108 cites W2058502868 @default.
• W4225270108 cites W205856494 @default.
• W4225270108 cites W2068854551 @default.
• W4225270108 cites W2084887202 @default.
• W4225270108 cites W2091655047 @default.
• W4225270108 cites W2094189284 @default.
• W4225270108 cites W2096200224 @default.
• W4225270108 cites W2104093114 @default.
• W4225270108 cites W2106735362 @default.
• W4225270108 cites W2108718949 @default.
• W4225270108 cites W2114997061 @default.
• W4225270108 cites W2115837368 @default.
• W4225270108 cites W2116753129 @default.
• W4225270108 cites W2125838338 @default.
• W4225270108 cites W2132646449 @default.
• W4225270108 cites W2135445066 @default.
• W4225270108 cites W2135944439 @default.
• W4225270108 cites W2145256501 @default.
• W4225270108 cites W2145429839 @default.
• W4225270108 cites W2155478691 @default.
• W4225270108 cites W2156564520 @default.
• W4225270108 cites W2161432863 @default.
• W4225270108 cites W2171556560 @default.
• W4225270108 cites W2237475190 @default.
• W4225270108 cites W2601140832 @default.
• W4225270108 cites W2732823864 @default.
• W4225270108 cites W2763147694 @default.
• W4225270108 cites W2770893462 @default.
• W4225270108 cites W2778778165 @default.
• W4225270108 cites W2790210268 @default.
• W4225270108 cites W2805130113 @default.
• W4225270108 cites W2818417770 @default.
• W4225270108 cites W2900668971 @default.
• W4225270108 cites W2954732721 @default.
• W4225270108 cites W2963196298 @default.
• W4225270108 cites W3109965948 @default.
• W4225270108 cites W3164603003 @default.
• W4225270108 doi "https://doi.org/10.1186/s12920-022-01247-3" @default.
• W4225270108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35501860" @default.
• W4225270108 hasPublicationYear "2022" @default.
• W4225270108 type Work @default.
• W4225270108 citedByCount "2" @default.
• W4225270108 countsByYear W42252701082022 @default.
• W4225270108 countsByYear W42252701082023 @default.
• W4225270108 crossrefType "journal-article" @default.
• W4225270108 hasAuthorship W4225270108A5042823264 @default.
• W4225270108 hasAuthorship W4225270108A5054755903 @default.
• W4225270108 hasAuthorship W4225270108A5056066550 @default.
• W4225270108 hasAuthorship W4225270108A5075011348 @default.
• W4225270108 hasBestOaLocation W42252701081 @default.
• W4225270108 hasConcept C104317684 @default.
• W4225270108 hasConcept C106208931 @default.
• W4225270108 hasConcept C135763542 @default.
• W4225270108 hasConcept C141231307 @default.
• W4225270108 hasConcept C144621757 @default.
• W4225270108 hasConcept C153209595 @default.
• W4225270108 hasConcept C186413461 @default.
• W4225270108 hasConcept C2991772755 @default.
• W4225270108 hasConcept C2993967602 @default.
• W4225270108 hasConcept C47042493 @default.
• W4225270108 hasConcept C54355233 @default.
• W4225270108 hasConcept C61727976 @default.
• W4225270108 hasConcept C70721500 @default.
• W4225270108 hasConcept C86803240 @default.
• W4225270108 hasConceptScore W4225270108C104317684 @default.
• W4225270108 hasConceptScore W4225270108C106208931 @default.
• W4225270108 hasConceptScore W4225270108C135763542 @default.
• W4225270108 hasConceptScore W4225270108C141231307 @default.
• W4225270108 hasConceptScore W4225270108C144621757 @default.
• W4225270108 hasConceptScore W4225270108C153209595 @default.
• W4225270108 hasConceptScore W4225270108C186413461 @default.
• W4225270108 hasConceptScore W4225270108C2991772755 @default.
• W4225270108 hasConceptScore W4225270108C2993967602 @default.
• W4225270108 hasConceptScore W4225270108C47042493 @default.
• W4225270108 hasConceptScore W4225270108C54355233 @default.
• W4225270108 hasConceptScore W4225270108C61727976 @default.
• W4225270108 hasConceptScore W4225270108C70721500 @default.
• W4225270108 hasConceptScore W4225270108C86803240 @default.
• W4225270108 hasFunder F4320316899 @default.
• W4225270108 hasFunder F4320320883 @default.
• W4225270108 hasIssue "1" @default.
• W4225270108 hasLocation W42252701081 @default.
• W4225270108 hasLocation W42252701082 @default.
• W4225270108 hasLocation W42252701083 @default.
• W4225270108 hasLocation W42252701084 @default.

• next