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• W4225270152 abstract "Increasing evidence points towards the key role of the epithelium in the systemic and over-activated immune response to viral infection, including SARS-CoV-2 infection. Yet, how viral infection alters epithelial-immune cell interactions regulating inflammatory responses, is not well known. Available experimental approaches are insufficient to properly analyse this complex system, and computational predictions and targeted data integration are needed as an alternative approach. In this work, we propose an integrated computational biology framework that models how infection alters intracellular signalling of epithelial cells and how this change impacts the systemic immune response through modified interactions between epithelial cells and local immune cell populations. As a proof-of-concept, we focused on the role of intestinal and upper-airway epithelial infection. To characterise the modified epithelial-immune interactome, we integrated intra- and intercellular networks with single-cell RNA-seq data from SARS-CoV-2 infected human ileal and colonic organoids as well as from infected airway ciliated epithelial cells. This integrated methodology has proven useful to point out specific epithelial-immune interactions driving inflammation during disease response, and propose relevant molecular targets to guide focused experimental analysis." @default.
• W4225270152 created "2022-05-04" @default.
• W4225270152 creator A5005499510 @default.
• W4225270152 creator A5011513198 @default.
• W4225270152 creator A5015157681 @default.
• W4225270152 creator A5023802736 @default.
• W4225270152 creator A5027550466 @default.
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• W4225270152 creator A5028302173 @default.
• W4225270152 creator A5030727182 @default.
• W4225270152 creator A5034282950 @default.
• W4225270152 creator A5036654221 @default.
• W4225270152 creator A5037926026 @default.
• W4225270152 creator A5039104079 @default.
• W4225270152 creator A5059582444 @default.
• W4225270152 creator A5065507596 @default.
• W4225270152 creator A5067295580 @default.
• W4225270152 creator A5069548197 @default.
• W4225270152 creator A5070745604 @default.
• W4225270152 date "2022-05-02" @default.
• W4225270152 modified "2023-10-10" @default.
• W4225270152 title "Mapping the epithelial–immune cell interactome upon infection in the gut and the upper airways" @default.
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