Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225276718> ?p ?o ?g. }
- W4225276718 endingPage "606" @default.
- W4225276718 startingPage "596" @default.
- W4225276718 abstract "Activity-dependent myelination can fine-tune neural network dynamics. Conversely, aberrant neuronal activity, as occurs in disorders of recurrent seizures (epilepsy), could promote maladaptive myelination, contributing to pathogenesis. In this study, we tested the hypothesis that activity-dependent myelination resulting from absence seizures, which manifest as frequent behavioral arrests with generalized electroencephalography (EEG) spike-wave discharges, promote thalamocortical network hypersynchrony and contribute to epilepsy progression. We found increased oligodendrogenesis and myelination specifically within the seizure network in two models of generalized epilepsy with absence seizures (Wag/Rij rats and Scn8a+/mut mice), evident only after epilepsy onset. Aberrant myelination was prevented by pharmacological seizure inhibition in Wag/Rij rats. Blocking activity-dependent myelination decreased seizure burden over time and reduced ictal synchrony as assessed by EEG coherence. These findings indicate that activity-dependent myelination driven by absence seizures contributes to epilepsy progression; maladaptive myelination may be pathogenic in some forms of epilepsy and other neurological diseases." @default.
- W4225276718 created "2022-05-04" @default.
- W4225276718 creator A5000848906 @default.
- W4225276718 creator A5003349135 @default.
- W4225276718 creator A5022800990 @default.
- W4225276718 creator A5023640403 @default.
- W4225276718 creator A5033400284 @default.
- W4225276718 creator A5033469821 @default.
- W4225276718 creator A5034122595 @default.
- W4225276718 creator A5034168187 @default.
- W4225276718 creator A5051294315 @default.
- W4225276718 creator A5060711550 @default.
- W4225276718 creator A5066215490 @default.
- W4225276718 creator A5068934771 @default.
- W4225276718 creator A5082981999 @default.
- W4225276718 date "2022-05-01" @default.
- W4225276718 modified "2023-10-15" @default.
- W4225276718 title "Maladaptive myelination promotes generalized epilepsy progression" @default.
- W4225276718 cites W1545733638 @default.
- W4225276718 cites W1886118302 @default.
- W4225276718 cites W1922602437 @default.
- W4225276718 cites W1964172997 @default.
- W4225276718 cites W1967937854 @default.
- W4225276718 cites W1971006243 @default.
- W4225276718 cites W1995185151 @default.
- W4225276718 cites W2001188679 @default.
- W4225276718 cites W2020372671 @default.
- W4225276718 cites W2021804790 @default.
- W4225276718 cites W2032292168 @default.
- W4225276718 cites W2056734213 @default.
- W4225276718 cites W2069769925 @default.
- W4225276718 cites W2072041708 @default.
- W4225276718 cites W2081771004 @default.
- W4225276718 cites W2085029391 @default.
- W4225276718 cites W2085529478 @default.
- W4225276718 cites W2090410452 @default.
- W4225276718 cites W2091603506 @default.
- W4225276718 cites W2120758016 @default.
- W4225276718 cites W2124025293 @default.
- W4225276718 cites W2145003526 @default.
- W4225276718 cites W2145772034 @default.
- W4225276718 cites W2157257192 @default.
- W4225276718 cites W2160165732 @default.
- W4225276718 cites W2411898393 @default.
- W4225276718 cites W2414699956 @default.
- W4225276718 cites W2501957447 @default.
- W4225276718 cites W2549152202 @default.
- W4225276718 cites W2565727305 @default.
- W4225276718 cites W2590568386 @default.
- W4225276718 cites W2611013877 @default.
- W4225276718 cites W2784326790 @default.
- W4225276718 cites W2790866686 @default.
- W4225276718 cites W2793201005 @default.
- W4225276718 cites W2795075974 @default.
- W4225276718 cites W2797102036 @default.
- W4225276718 cites W2903050755 @default.
- W4225276718 cites W2916024926 @default.
- W4225276718 cites W2945566268 @default.
- W4225276718 cites W2946168453 @default.
- W4225276718 cites W2966039191 @default.
- W4225276718 cites W2970490662 @default.
- W4225276718 cites W2980716370 @default.
- W4225276718 cites W2981630556 @default.
- W4225276718 cites W2983638220 @default.
- W4225276718 cites W3005032553 @default.
- W4225276718 cites W3029829036 @default.
- W4225276718 cites W3081310575 @default.
- W4225276718 cites W3094462456 @default.
- W4225276718 cites W3110704710 @default.
- W4225276718 cites W3118597387 @default.
- W4225276718 cites W3125220517 @default.
- W4225276718 cites W4240496409 @default.
- W4225276718 doi "https://doi.org/10.1038/s41593-022-01052-2" @default.
- W4225276718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35501379" @default.
- W4225276718 hasPublicationYear "2022" @default.
- W4225276718 type Work @default.
- W4225276718 citedByCount "26" @default.
- W4225276718 countsByYear W42252767182022 @default.
- W4225276718 countsByYear W42252767182023 @default.
- W4225276718 crossrefType "journal-article" @default.
- W4225276718 hasAuthorship W4225276718A5000848906 @default.
- W4225276718 hasAuthorship W4225276718A5003349135 @default.
- W4225276718 hasAuthorship W4225276718A5022800990 @default.
- W4225276718 hasAuthorship W4225276718A5023640403 @default.
- W4225276718 hasAuthorship W4225276718A5033400284 @default.
- W4225276718 hasAuthorship W4225276718A5033469821 @default.
- W4225276718 hasAuthorship W4225276718A5034122595 @default.
- W4225276718 hasAuthorship W4225276718A5034168187 @default.
- W4225276718 hasAuthorship W4225276718A5051294315 @default.
- W4225276718 hasAuthorship W4225276718A5060711550 @default.
- W4225276718 hasAuthorship W4225276718A5066215490 @default.
- W4225276718 hasAuthorship W4225276718A5068934771 @default.
- W4225276718 hasAuthorship W4225276718A5082981999 @default.
- W4225276718 hasBestOaLocation W42252767181 @default.
- W4225276718 hasConcept C15744967 @default.
- W4225276718 hasConcept C169760540 @default.
- W4225276718 hasConcept C17755696 @default.
- W4225276718 hasConcept C2778186239 @default.