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- W4225277887 abstract "ABSTRACT The compartmentalized domains of polarized epithelial cells arise from mutually antagonistic actions between the apical Par complex and the basolateral Scrib module. In Drosophila , the Scrib module proteins Scribble (Scrib) and Discs-large (Dlg) are required to limit Lgl phosphorylation at the basolateral cortex, but how Scrib and Dlg could carry out such a ‘protection’ activity is not clear. We tested Protein Phosphatase 1α (PP1) as a potential mediator of this activity but demonstrate that a significant component of Scrib and Dlg regulation of Lgl is PP1-independent and found no evidence for a Scrib-Dlg-PP1 protein complex. However, the Dlg SH3 domain plays a role in Lgl protection and, in combination with the N-terminal region of the Dlg HOOK domain, in recruitment of Scrib to the membrane. We identify a ‘minimal Dlg’ comprised of the SH3 and HOOK domains that is both necessary and sufficient for Scrib localization and epithelial polarity function in vivo . Summary Statement A minimal SH3-HOOK fragment of Dlg is sufficient to support epithelial polarity through mechanisms independent of the PP1 phosphatase." @default.
- W4225277887 created "2022-05-04" @default.
- W4225277887 creator A5014248978 @default.
- W4225277887 creator A5062920414 @default.
- W4225277887 date "2022-05-02" @default.
- W4225277887 modified "2023-09-26" @default.
- W4225277887 title "Minimal functional domains of the core polarity regulator Dlg" @default.
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- W4225277887 doi "https://doi.org/10.1101/2022.04.29.490107" @default.
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