FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225281617> ?p ?o ?g. }

• W4225281617 endingPage "5041" @default.
• W4225281617 startingPage "5041" @default.
• W4225281617 abstract "Poly ADP-ribosylation (PARylation) is a post-translational modification catalyzed by poly (ADP-ribose) polymerase (PARP) family proteins such as PARP1. Although PARylation regulates important biological phenomena such as DNA repair, chromatin regulation, and cell death, little is known about the relationship between osteoblast differentiation and the PARylation cycle involving PARP1 and the poly (ADP-ribose)-degrading enzyme poly (ADP-ribose) glycohydrolase (PARG). Here, we examined the effects of PARP inhibitor olaparib, an approved anti-cancer agent, and PARG inhibitor PDD00017273 on osteoblast differentiation. Olaparib decreased alkaline phosphatase (ALP) activity and suppressed mineralized nodule formation evaluated by Alizarin Red S staining in preosteoblastic MC3T3-E1 cells, while PDD00017273 promoted ALP activity and mineralization. Furthermore, PDD00017273 up-regulated the mRNA expression levels of osteocalcin and bone sialoprotein, as osteoblast differentiation markers, and osterix as transcription inducers for osteoblast differentiation, whereas olaparib down-regulated the expression of these genes. These findings suggest that PARG inhibition by PDD00017273 accelerates osteoblast differentiation in MC3T3-E1 cells. Thus, PARG inhibitor administration could provide therapeutic benefits for metabolic bone diseases such as osteoporosis." @default.
• W4225281617 created "2022-05-04" @default.
• W4225281617 creator A5007880174 @default.
• W4225281617 creator A5014960402 @default.
• W4225281617 creator A5052439214 @default.
• W4225281617 creator A5056402317 @default.
• W4225281617 creator A5067674764 @default.
• W4225281617 date "2022-05-02" @default.
• W4225281617 modified "2023-09-30" @default.
• W4225281617 title "Inhibition of Poly (ADP-Ribose) Glycohydrolase Accelerates Osteoblast Differentiation in Preosteoblastic MC3T3-E1 Cells" @default.
• W4225281617 cites W1504661786 @default.
• W4225281617 cites W1536009441 @default.
• W4225281617 cites W1622927134 @default.
• W4225281617 cites W1944141551 @default.
• W4225281617 cites W1978228345 @default.
• W4225281617 cites W1985716862 @default.
• W4225281617 cites W1990960553 @default.
• W4225281617 cites W2004924148 @default.
• W4225281617 cites W2009899606 @default.
• W4225281617 cites W2033530630 @default.
• W4225281617 cites W2052845629 @default.
• W4225281617 cites W2054822314 @default.
• W4225281617 cites W2122367477 @default.
• W4225281617 cites W2170321545 @default.
• W4225281617 cites W2527103315 @default.
• W4225281617 cites W2732346161 @default.
• W4225281617 cites W2905094310 @default.
• W4225281617 cites W2922360615 @default.
• W4225281617 cites W2947643262 @default.
• W4225281617 cites W2951218703 @default.
• W4225281617 cites W2978412271 @default.
• W4225281617 cites W3005496161 @default.
• W4225281617 cites W3114793177 @default.
• W4225281617 cites W3133725907 @default.
• W4225281617 cites W3197453909 @default.
• W4225281617 doi "https://doi.org/10.3390/ijms23095041" @default.
• W4225281617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35563432" @default.
• W4225281617 hasPublicationYear "2022" @default.
• W4225281617 type Work @default.
• W4225281617 citedByCount "2" @default.
• W4225281617 countsByYear W42252816172022 @default.
• W4225281617 countsByYear W42252816172023 @default.
• W4225281617 crossrefType "journal-article" @default.
• W4225281617 hasAuthorship W4225281617A5007880174 @default.
• W4225281617 hasAuthorship W4225281617A5014960402 @default.
• W4225281617 hasAuthorship W4225281617A5052439214 @default.
• W4225281617 hasAuthorship W4225281617A5056402317 @default.
• W4225281617 hasAuthorship W4225281617A5067674764 @default.
• W4225281617 hasBestOaLocation W42252816171 @default.
• W4225281617 hasConcept C104317684 @default.
• W4225281617 hasConcept C131075544 @default.
• W4225281617 hasConcept C148738053 @default.
• W4225281617 hasConcept C153911025 @default.
• W4225281617 hasConcept C160160445 @default.
• W4225281617 hasConcept C181199279 @default.
• W4225281617 hasConcept C182979987 @default.
• W4225281617 hasConcept C185592680 @default.
• W4225281617 hasConcept C202751555 @default.
• W4225281617 hasConcept C2776432469 @default.
• W4225281617 hasConcept C2778260815 @default.
• W4225281617 hasConcept C2778480876 @default.
• W4225281617 hasConcept C2779962180 @default.
• W4225281617 hasConcept C55493867 @default.
• W4225281617 hasConcept C82381507 @default.
• W4225281617 hasConcept C86803240 @default.
• W4225281617 hasConcept C95444343 @default.
• W4225281617 hasConceptScore W4225281617C104317684 @default.
• W4225281617 hasConceptScore W4225281617C131075544 @default.
• W4225281617 hasConceptScore W4225281617C148738053 @default.
• W4225281617 hasConceptScore W4225281617C153911025 @default.
• W4225281617 hasConceptScore W4225281617C160160445 @default.
• W4225281617 hasConceptScore W4225281617C181199279 @default.
• W4225281617 hasConceptScore W4225281617C182979987 @default.
• W4225281617 hasConceptScore W4225281617C185592680 @default.
• W4225281617 hasConceptScore W4225281617C202751555 @default.
• W4225281617 hasConceptScore W4225281617C2776432469 @default.
• W4225281617 hasConceptScore W4225281617C2778260815 @default.
• W4225281617 hasConceptScore W4225281617C2778480876 @default.
• W4225281617 hasConceptScore W4225281617C2779962180 @default.
• W4225281617 hasConceptScore W4225281617C55493867 @default.
• W4225281617 hasConceptScore W4225281617C82381507 @default.
• W4225281617 hasConceptScore W4225281617C86803240 @default.
• W4225281617 hasConceptScore W4225281617C95444343 @default.
• W4225281617 hasFunder F4320334764 @default.
• W4225281617 hasIssue "9" @default.
• W4225281617 hasLocation W42252816171 @default.
• W4225281617 hasLocation W42252816172 @default.
• W4225281617 hasLocation W42252816173 @default.
• W4225281617 hasOpenAccess W4225281617 @default.
• W4225281617 hasPrimaryLocation W42252816171 @default.
• W4225281617 hasRelatedWork W1568198266 @default.
• W4225281617 hasRelatedWork W1981582835 @default.
• W4225281617 hasRelatedWork W2028553359 @default.
• W4225281617 hasRelatedWork W2044971600 @default.
• W4225281617 hasRelatedWork W2068520348 @default.
• W4225281617 hasRelatedWork W2093786715 @default.
• W4225281617 hasRelatedWork W2097207537 @default.
• W4225281617 hasRelatedWork W2313637060 @default.

• next