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• W4225281750 endingPage "e202101326" @default.
• W4225281750 startingPage "e202101326" @default.
• W4225281750 abstract "Mutations in the CFTR anion channel cause cystic fibrosis (CF) and have also been related to higher cancer incidence. Previously we proposed that this is linked to an emerging role of functional CFTR in protecting against epithelial–mesenchymal transition (EMT). However, the pathways bridging dysfunctional CFTR to EMT remain elusive. Here, we applied systems biology to address this question. Our data show that YAP1 is aberrantly active in the presence of mutant CFTR, interacting with F508del, but not with wt-CFTR, and that YAP1 knockdown rescues F508del-CFTR processing and function. Subsequent analysis of YAP1 interactors and roles in cells expressing either wt- or F508del-CFTR reveal that YAP1 is an important mediator of the fibrotic/EMT processes in CF. Alongside, five main pathways emerge here as key in linking mutant CFTR to EMT, namely, (1) the Hippo pathway; (2) the Wnt pathway; (3) the TGFβ pathway; (4) the p53 pathway; and (5) MYC signaling. Several potential hub proteins which mediate the crosstalk among these pathways were also identified, appearing as potential therapeutic targets for both CF and cancer." @default.
• W4225281750 created "2022-05-04" @default.
• W4225281750 creator A5003865564 @default.
• W4225281750 creator A5006231347 @default.
• W4225281750 creator A5032868687 @default.
• W4225281750 creator A5044458334 @default.
• W4225281750 creator A5052773295 @default.
• W4225281750 creator A5075527165 @default.
• W4225281750 creator A5077647530 @default.
• W4225281750 date "2022-05-02" @default.
• W4225281750 modified "2023-09-27" @default.
• W4225281750 title "Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition" @default.
• W4225281750 cites W1431954835 @default.
• W4225281750 cites W1489106364 @default.
• W4225281750 cites W1607926222 @default.
• W4225281750 cites W1914659192 @default.
• W4225281750 cites W1964847767 @default.
• W4225281750 cites W1973527232 @default.
• W4225281750 cites W1978888457 @default.
• W4225281750 cites W1990877187 @default.
• W4225281750 cites W1999332213 @default.
• W4225281750 cites W2018982025 @default.
• W4225281750 cites W2021015220 @default.
• W4225281750 cites W2028234509 @default.
• W4225281750 cites W2039599894 @default.
• W4225281750 cites W2049319639 @default.
• W4225281750 cites W2049914201 @default.
• W4225281750 cites W2050345155 @default.
• W4225281750 cites W2053600371 @default.
• W4225281750 cites W2055953510 @default.
• W4225281750 cites W2060955824 @default.
• W4225281750 cites W2061464808 @default.
• W4225281750 cites W2072386674 @default.
• W4225281750 cites W2080347068 @default.
• W4225281750 cites W2086380492 @default.
• W4225281750 cites W2086508420 @default.
• W4225281750 cites W2089230533 @default.
• W4225281750 cites W2092290930 @default.
• W4225281750 cites W2098190253 @default.
• W4225281750 cites W2099709490 @default.
• W4225281750 cites W2109347073 @default.
• W4225281750 cites W2117811962 @default.
• W4225281750 cites W2118971140 @default.
• W4225281750 cites W2130410032 @default.
• W4225281750 cites W2139746915 @default.
• W4225281750 cites W2141595533 @default.
• W4225281750 cites W2146337514 @default.
• W4225281750 cites W2152355434 @default.
• W4225281750 cites W2152673858 @default.
• W4225281750 cites W2159997339 @default.
• W4225281750 cites W2160606755 @default.
• W4225281750 cites W2167279371 @default.
• W4225281750 cites W2167978765 @default.
• W4225281750 cites W2168072233 @default.
• W4225281750 cites W2188967200 @default.
• W4225281750 cites W2221934150 @default.
• W4225281750 cites W2234614402 @default.
• W4225281750 cites W2265166065 @default.
• W4225281750 cites W2301131921 @default.
• W4225281750 cites W2316431812 @default.
• W4225281750 cites W2338138835 @default.
• W4225281750 cites W2426003472 @default.
• W4225281750 cites W2530681127 @default.
• W4225281750 cites W2535345601 @default.
• W4225281750 cites W2726311377 @default.
• W4225281750 cites W2743069566 @default.
• W4225281750 cites W2768981280 @default.
• W4225281750 cites W2774835966 @default.
• W4225281750 cites W2796153225 @default.
• W4225281750 cites W2895920254 @default.
• W4225281750 cites W2899756901 @default.
• W4225281750 cites W2900569176 @default.
• W4225281750 cites W2908013762 @default.
• W4225281750 cites W2910874028 @default.
• W4225281750 cites W2915102066 @default.
• W4225281750 cites W2950082681 @default.
• W4225281750 cites W2950306742 @default.
• W4225281750 cites W2958392354 @default.
• W4225281750 cites W2965230527 @default.
• W4225281750 cites W2966761201 @default.
• W4225281750 cites W2966798736 @default.
• W4225281750 cites W2980616295 @default.
• W4225281750 cites W2990565248 @default.
• W4225281750 cites W2996992443 @default.
• W4225281750 cites W2997710838 @default.
• W4225281750 cites W3016840787 @default.
• W4225281750 cites W3023332604 @default.
• W4225281750 cites W3036513507 @default.
• W4225281750 cites W3047790731 @default.
• W4225281750 cites W3049637556 @default.
• W4225281750 cites W3093507140 @default.
• W4225281750 cites W3094194132 @default.
• W4225281750 cites W3110917833 @default.
• W4225281750 cites W3115175786 @default.
• W4225281750 cites W3125036414 @default.
• W4225281750 cites W4210996550 @default.
• W4225281750 cites W4211233744 @default.
• W4225281750 cites W4214618444 @default.

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