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• W4225282435 abstract "Significance Statement Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are candidates for mediating the effect of BMI on ESKD. However, the independent contributions of these factors have not been quantified in prospective studies to date. Applying a model of mediation, the authors quantified the contribution of these four metabolic factors to the association of BMI with ESKD in a population-based cohort of 100,269 predominantly healthy Austrian individuals. They found that the association of BMI with ESKD was mediated through TyG index (a measure of insulin resistance), mean arterial pressure, and uric acid, but not through total cholesterol. The findings suggest that in addition to weight reduction, the control of metabolic risk factors is important in mitigating the adverse effects of BMI on kidney function. Background Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight and CKD risk. However, the magnitude of the total effect of excess body weight on ESKD mediated through these four pathways remains to be quantified. Methods We applied a model for analysis of correlated mediators to population-based data from 100,269 Austrian individuals (mean age 46.4 years). Association of body mass index (BMI) was coalesced with ESKD risk into direct association. Indirect associations were mediated through the triglyceride-glucose (TyG) index (as an indicator of insulin resistance), mean arterial pressure (MAP), uric acid (UA), and total cholesterol (TC). Results Mean follow-up was 23.1 years with 463 (0.5%) incident ESKD cases. An unhealthy metabolic profile (prevalence 32.4%) was associated with a markedly increased ESKD risk (multivariably adjusted hazard ratio (aHR), 3.57; 95% CI, 2.89 to 4.40), independent of BMI. A 5-kg/m 2 higher BMI was associated with a 57% increased ESKD risk (aHR total association , 1.57; 1.38 to 1.77). Of this association, 99% (76% to 140%) arose from all mediators jointly; 33% (22% to 49%) through TyG index; 34% (24% to 50%) through MAP; 30% (21% to 45%) through UA; and 2% (−1% to 4%) through TC. The remaining direct association was nonsignificant (aHR direct association , 1.01; 0.88 to 1.14). Conclusions TyG index, MAP, and UA, but not TC, mediate the association of BMI with ESKD in middle-aged adults. Our findings highlight that in addition to weight reduction, the control of metabolic risk factors might be essential in mitigating the adverse effects of BMI on kidney function." @default.
• W4225282435 created "2022-05-04" @default.
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• W4225282435 date "2022-07-01" @default.
• W4225282435 modified "2023-10-05" @default.
• W4225282435 title "The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia" @default.
• W4225282435 cites W1491124385 @default.
• W4225282435 cites W1607804102 @default.
• W4225282435 cites W1706710719 @default.
• W4225282435 cites W1715498292 @default.
• W4225282435 cites W1905082515 @default.
• W4225282435 cites W1967999753 @default.
• W4225282435 cites W1969455198 @default.
• W4225282435 cites W1971851436 @default.
• W4225282435 cites W1976456906 @default.
• W4225282435 cites W1982245891 @default.
• W4225282435 cites W1989878428 @default.
• W4225282435 cites W1993336979 @default.
• W4225282435 cites W2001820152 @default.
• W4225282435 cites W2007217300 @default.
• W4225282435 cites W2009754435 @default.
• W4225282435 cites W2012967253 @default.
• W4225282435 cites W2013332206 @default.
• W4225282435 cites W2019071861 @default.
• W4225282435 cites W2052658828 @default.
• W4225282435 cites W2055563029 @default.
• W4225282435 cites W2064707735 @default.
• W4225282435 cites W2076128320 @default.
• W4225282435 cites W2080760372 @default.
• W4225282435 cites W2085618156 @default.
• W4225282435 cites W2096773810 @default.
• W4225282435 cites W2104155993 @default.
• W4225282435 cites W2109605737 @default.
• W4225282435 cites W2120479558 @default.
• W4225282435 cites W2122730408 @default.
• W4225282435 cites W2132647859 @default.
• W4225282435 cites W2139664471 @default.
• W4225282435 cites W2151009383 @default.
• W4225282435 cites W2153739619 @default.
• W4225282435 cites W2155234305 @default.
• W4225282435 cites W2159511512 @default.
• W4225282435 cites W2168228968 @default.
• W4225282435 cites W2193561325 @default.
• W4225282435 cites W2272106152 @default.
• W4225282435 cites W2318408074 @default.
• W4225282435 cites W2336361163 @default.
• W4225282435 cites W2536523837 @default.
• W4225282435 cites W2553261268 @default.
• W4225282435 cites W2554192146 @default.
• W4225282435 cites W2557935089 @default.
• W4225282435 cites W2572446923 @default.
• W4225282435 cites W2575402762 @default.
• W4225282435 cites W2587125180 @default.
• W4225282435 cites W2593429896 @default.
• W4225282435 cites W2598682643 @default.
• W4225282435 cites W2735376054 @default.
• W4225282435 cites W2761274804 @default.
• W4225282435 cites W2766498687 @default.
• W4225282435 cites W2793526329 @default.
• W4225282435 cites W2807249085 @default.
• W4225282435 cites W2808364546 @default.
• W4225282435 cites W2910107074 @default.
• W4225282435 cites W2913672674 @default.
• W4225282435 cites W2942253286 @default.
• W4225282435 cites W2961917496 @default.
• W4225282435 cites W2994756276 @default.
• W4225282435 cites W3037804099 @default.
• W4225282435 cites W3038080478 @default.
• W4225282435 cites W3088173406 @default.
• W4225282435 cites W3096101149 @default.
• W4225282435 cites W3145665663 @default.
• W4225282435 cites W4292811746 @default.
• W4225282435 cites W4294116629 @default.
• W4225282435 cites W4296883165 @default.
• W4225282435 cites W4385826776 @default.
• W4225282435 cites W911728069 @default.
• W4225282435 cites W3174461150 @default.
• W4225282435 doi "https://doi.org/10.1681/asn.2021091263" @default.
• W4225282435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35500938" @default.
• W4225282435 hasPublicationYear "2022" @default.
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