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- W4225282441 endingPage "1835" @default.
- W4225282441 startingPage "1835" @default.
- W4225282441 abstract "Turmeric oil (TO) exhibits various biological activities with limited therapeutic applications due to its instability, volatility, and poor water solubility. Here, we encapsulated TO in chitosan/alginate nanocapsules (CS/Alg-NCs) using o/w emulsification to enhance its physicochemical characteristics, using poloxamer 407 as a non-ionic surfactant. TO-loaded CS/Alg-NCs (TO-CS/Alg-NCs) were prepared with satisfactory features, encapsulation efficiency, release characteristics, and cytotoxicity against breast cancer cells. The average size of the fabricated TO-CS/Alg-NCs was around 200 nm; their distribution was homogenous, and their shapes were spherical, with smooth surfaces. The TO-CS/Alg-NCs showed a high encapsulation efficiency, of 70%, with a sustained release of TO at approximately 50% after 12 h at pH 7.4 and 5.5. The TO-CS/Alg-NCs demonstrated enhanced cytotoxicity against two breast cancer cells, MDA-MB-231 and MCF-7, compared to the unencapsulated TO, suggesting that CS/Alg-NCs are potential nanocarriers for TO and can serve as prospective candidates for in vivo anticancer activity evaluation." @default.
- W4225282441 created "2022-05-04" @default.
- W4225282441 creator A5015154589 @default.
- W4225282441 creator A5020566447 @default.
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- W4225282441 creator A5056043799 @default.
- W4225282441 creator A5071304823 @default.
- W4225282441 creator A5083160636 @default.
- W4225282441 date "2022-04-29" @default.
- W4225282441 modified "2023-09-26" @default.
- W4225282441 title "Development of Turmeric Oil—Loaded Chitosan/Alginate Nanocapsules for Cytotoxicity Enhancement against Breast Cancer" @default.
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- W4225282441 doi "https://doi.org/10.3390/polym14091835" @default.
- W4225282441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35567007" @default.
- W4225282441 hasPublicationYear "2022" @default.
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