Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225285812> ?p ?o ?g. }
- W4225285812 abstract "Abstract The loss of neurons is one of the most irreversible phenomena in traumatic injuries to the central nervous system (CNS). One of the recent approaches to replace the lost neurons is delivering stem cells to the lesion area and differentiating them using biodegradable scaffolds. Alginate has been known as an efficient hydrogel for this target. However, its bioactivity needs to be improved to promote cell adhesion/differentiation. In this study, alginate hydrogel was synthesized and optimized regarding mechanical properties of the CNS, and its bioactivity was improved using Schwann cell‐ and fibroblast‐derived extracellular matrix (ECM). The results of immunostaining showed higher differentiation efficacy on ECM‐modified hydrogels than controls. Although secreted protein content by fibroblast was 12.01 ± 2.09 folds higher than Schwann cells, no significant difference was observed between the differentiation potential of ECM‐modified hydrogels. Accordingly, both ECM‐modified hydrogels can be an appropriate scaffold to promote differentiation toward neuron‐like cells and, subsequently, nerve regeneration." @default.
- W4225285812 created "2022-05-05" @default.
- W4225285812 creator A5033916155 @default.
- W4225285812 creator A5034362563 @default.
- W4225285812 creator A5038540288 @default.
- W4225285812 creator A5066326516 @default.
- W4225285812 date "2022-05-02" @default.
- W4225285812 modified "2023-09-26" @default.
- W4225285812 title "Modification of the alginate hydrogel with fibroblast‐ and Schwann cell‐derived extracellular matrix potentiates differentiation of mesenchymal stem cells toward neuron‐like cells" @default.
- W4225285812 cites W1418511128 @default.
- W4225285812 cites W1591103981 @default.
- W4225285812 cites W1848319253 @default.
- W4225285812 cites W1881164104 @default.
- W4225285812 cites W1892006814 @default.
- W4225285812 cites W1935012038 @default.
- W4225285812 cites W1963938604 @default.
- W4225285812 cites W1968036386 @default.
- W4225285812 cites W1970576706 @default.
- W4225285812 cites W1971644755 @default.
- W4225285812 cites W1982240728 @default.
- W4225285812 cites W1986341797 @default.
- W4225285812 cites W1991795415 @default.
- W4225285812 cites W2005848913 @default.
- W4225285812 cites W2015449479 @default.
- W4225285812 cites W2017479759 @default.
- W4225285812 cites W2023285758 @default.
- W4225285812 cites W2024673558 @default.
- W4225285812 cites W2025341270 @default.
- W4225285812 cites W2035120744 @default.
- W4225285812 cites W2044592690 @default.
- W4225285812 cites W2051356821 @default.
- W4225285812 cites W2051766546 @default.
- W4225285812 cites W2055604817 @default.
- W4225285812 cites W2059134148 @default.
- W4225285812 cites W2065337627 @default.
- W4225285812 cites W2073795835 @default.
- W4225285812 cites W2075768215 @default.
- W4225285812 cites W2076181442 @default.
- W4225285812 cites W2083537177 @default.
- W4225285812 cites W2086228870 @default.
- W4225285812 cites W2087255769 @default.
- W4225285812 cites W2087726019 @default.
- W4225285812 cites W2088184845 @default.
- W4225285812 cites W2093417927 @default.
- W4225285812 cites W2095301611 @default.
- W4225285812 cites W2098737512 @default.
- W4225285812 cites W2102232105 @default.
- W4225285812 cites W2103417481 @default.
- W4225285812 cites W2106416826 @default.
- W4225285812 cites W2112899131 @default.
- W4225285812 cites W2115062578 @default.
- W4225285812 cites W2120320857 @default.
- W4225285812 cites W2126961438 @default.
- W4225285812 cites W2130396479 @default.
- W4225285812 cites W2140712402 @default.
- W4225285812 cites W2141547693 @default.
- W4225285812 cites W2155801476 @default.
- W4225285812 cites W2165230539 @default.
- W4225285812 cites W2173497140 @default.
- W4225285812 cites W2177483881 @default.
- W4225285812 cites W2224935128 @default.
- W4225285812 cites W2408269815 @default.
- W4225285812 cites W2484283047 @default.
- W4225285812 cites W2510103591 @default.
- W4225285812 cites W2552175447 @default.
- W4225285812 cites W2560788019 @default.
- W4225285812 cites W2560810249 @default.
- W4225285812 cites W2765182005 @default.
- W4225285812 cites W2795087713 @default.
- W4225285812 cites W2800940693 @default.
- W4225285812 cites W2904971831 @default.
- W4225285812 cites W2909387807 @default.
- W4225285812 cites W2987713017 @default.
- W4225285812 cites W3005343002 @default.
- W4225285812 doi "https://doi.org/10.1002/app.52501" @default.
- W4225285812 hasPublicationYear "2022" @default.
- W4225285812 type Work @default.
- W4225285812 citedByCount "1" @default.
- W4225285812 countsByYear W42252858122023 @default.
- W4225285812 crossrefType "journal-article" @default.
- W4225285812 hasAuthorship W4225285812A5033916155 @default.
- W4225285812 hasAuthorship W4225285812A5034362563 @default.
- W4225285812 hasAuthorship W4225285812A5038540288 @default.
- W4225285812 hasAuthorship W4225285812A5066326516 @default.
- W4225285812 hasConcept C104317684 @default.
- W4225285812 hasConcept C108586683 @default.
- W4225285812 hasConcept C136229726 @default.
- W4225285812 hasConcept C148738053 @default.
- W4225285812 hasConcept C169760540 @default.
- W4225285812 hasConcept C171056886 @default.
- W4225285812 hasConcept C185592680 @default.
- W4225285812 hasConcept C188027245 @default.
- W4225285812 hasConcept C189165786 @default.
- W4225285812 hasConcept C192562407 @default.
- W4225285812 hasConcept C198826908 @default.
- W4225285812 hasConcept C202751555 @default.
- W4225285812 hasConcept C2777004073 @default.
- W4225285812 hasConcept C2778794669 @default.
- W4225285812 hasConcept C2780381497 @default.
- W4225285812 hasConcept C28406088 @default.